CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Biomedicina from Universidade de Santo Amaro (2007), master's at Pharmacology from Universidade Federal de São Paulo (2010) and doctorate at Pharmacology from Universidade Federal de São Paulo (2014). , acting on the following subjects: renovascular, atividade simpática renal, medula espinal, losartana and rvlm. (Source: Lattes Curriculum)
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Studies have shown a strong neurogenic component in the onset of Arterial Hypertension (AH) in humans and experimental models. Renal denervation in hypertensive patients resistant to pharmacological treatment is an effective strategy in the control of Blood Pressure (BP), which has been attributed to the interruption of renal sympathetic and afferents fibers. Our previous studies showed a…
The sympathetic nervous system has been highlighted as an important therapeutic target for arterial hypertension (AH) by using renal denervation in patients and experimental models. Clinical studies in patients with chronic kidney disease (CKD) have shown that renal denervation, which destroys both sympathetic and sensory fibers that innervate the kidney, promotes not only renoprotective …
The prevalence of chronic kidney disease (CKD) is increasing worldwide and the main contributors to CKD progression are arterial hypertension (AH) and diabetes. Despite advances in pharmacological treatments with antihypertensive and antidiabetic drugs, the alarming number of patients with nephropathy shows the need for new therapeutic strategies. The sympathetic nervous system (SNS) has …
It is known that renal oxidative stress reflects an imbalance between increased generation of oxidants and attenuated antioxidant defense systems and it has been demonstrated that it plays an important role in arterial hypertension. In hypertension, elevated levels of angiotensin II (Ang II) activates NAD(P)H oxidases via interaction with Ang II type 1 (AT-1) receptors thereby producing o…
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Several neurohumoral factors contribute to cardiovascular and adipose tissue dysfunction in obesity. In a previous study, we showed that retroperitoneal white adipose tissue innervation influences baroreflex control of blood pressure, circulating angiotensinogen, as well as inflammation markers in target organs in high-fat-fed (HF) rats with increased sympathetic drive. Moreover, it has b…
Studies have shown that the renal nerves play a major role in the maintenance of arterial hypertension (AH) in humans and experimental models. Our previous studies demonstrated that renal denervation (RDN) normalized urinary angiotensinogen and protein levels, reduced markers of renal injury, renal function, oxidative damage, and inflammation in experimental models of renovascular hyperte…
Arterial hypertension is a complex syndrome mediated by genetic and environmental factors. Because several interacting mechanisms are involved in the maintenance of hypertension the control of high blood pressure (BP) is still a challenge. The sympathoexcitation and the renin angiotensin (Ang) system activation are main targets in the treatment of hypertension, thus, our aim is to underst…
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| 8 / 6 | Completed scholarships in Brazil |
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