Graduated in Medicine in 1979, achieved PhD in 1997 in Neurology, at School of Medicine of São Paulo University. Currently is associate professor at the Department of Neurology of FMUSP, and head of the Cellular e Molecular Biology Laboratory at School of Medicine of University of Sao Paulo. The main reserach is in the field of mitochondriopaties, and the studies have focused on alterations of mitocondrial genome, copy number, trasncription machinery alterations and glycolitical and oxidative metabolism unbalance in neurodegenerative diseases and solid tumors. (Source: Lattes Curriculum)
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The extracellular matrix (ECM) differs greatly across organs owing to complex variations required for specific organ structure and function. ECM modulates cell behavior and regulates cell-cell interactions in physiological mechanisms, processes largely dependent on modulation of cell signaling pathways. Disruptions of these mechanisms may lead to disease. In the current project we propose…
The Extracellular Matrix (ECM) differs greatly across organs owing to complex variations required for specific organ structure and function. ECM modulates cell behavior and regulates cell-cell interactions in physiological mechanisms, processes largely dependent on modulation of cell signaling pathways. Disruptions of these mechanisms may lead to disease. In the current project we propose…
Recent studies and accomplishments on monogenic diseases have served not only to alleviate the dilemma of patients with these disorders, but also have yielded valuable information on biological processes relevant to other more common conditions. However, few centers are prepared to diagnose, follow up, and investigate monogenic developmental diseases in Brazil, the largest Latin American …
Glioblastoma (GBM) is an aggressive form of brain tumor characterized by infiltration in the brain. GBM is generally resistant to chemotherapy and radiation. After surgical resection and treatment, virtually all GBM tumors recur within the first years after diagnosis, resulting in poor survival prognosis. In GBM, a small fraction of cells with neural stem cell (NSC)-like characteristics h…
Inhibitor of DNA Binding 4 (ID4) is a member of the helix-loop-helix ID family of transcription factors, mostly present in the central nervous system during embryonic development, that has been associated with TP53 mutation and activation of SOX2. Along with other transcription factors, ID4 has been implicated in the tumorigenic process of astrocytomas, contributing to cell dedifferentiat…
(Only some records are available in English at this moment)
The project aims to investigate the expression of the matrisome, composed of components of the extracellular matrix, in eight different human brain sites from autopsies. Preliminary analysis involved examining variations in the expression of genes encoding core matrisome proteins in tissues from the cerebellum (9), hippocampus (HCP; 8), hypothalamus (7), substantia nigra (5), and isocorte…
The inadequate metabolic control in diabetes mellitus (DM), a high prevalence disease, lead to chronic macro and microvascular complications in long term, with impact in the morbility and mortality of this population. Retinopathy, nefropathy, cardiovascular disautonomic neuropathy, distal neuropathy and diabetic encephalopathy (DE) are among the DM clinical complications, and DE may lead …
Craniopharyngiomas (CRF) are relatively rare benign neoplasms of the Central Nervous System, derived from remnants of the craniopharyngeal epithelial duct. Despite their histological characteristics, these tumors pose significant challenges in clinical and surgical management due to their proximity to the optic pathways, pituitary gland and stalk, third ventricle, and hypothalamus.There a…
The proteoglycans represent an important class of molecules localized in the extracellular matrix, which are responsible for several functions encompassing the regulation of physiological and pathological mechanisms. The focus of this research project is to study the proteoglycans and hyaluronic acid-associated proteins in the human brain extracellular matrix and the distribution of their…
Toll like receptor 4 (TLR4) has a significant role in innate immunity. Right after activation, TLR4 signals through MyD88 pathway, producing a pro-inflammatory response and cell proliferation. This signal pathway induces NF-kB translocation to the nucleus and cytokine production. TLR4 is also internalized to the endosome and signals through TRIF, producing an anti-inflammatory response an…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 15 / 7 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 21 / 12 | Completed scholarships in Brazil |
| 40 / 23 | All research grants and scholarships |
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CV Lattes
ORCID