CV Lattes
ORCID
Abstract
Shiga toxin-producing Escherichia coli (STEC) strains can cause hemorrhagic colitis and hemolytic uremic syndrome by producing Shiga cytotoxin (Stx), a toxin that inhibits protein synthesis by acting on rRNA, leading to cell death. As there is no available antidote, current therapy only involves treating symptoms. Monoclonal antibody fragments have become an important class of biopharmace…