Alice Santana Morais
CV Lattes
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Biomedicine by the Lusiada University Center (2008) and carried out Scientific Initiation at the Federal University of São Paulo (2007-2008). He is qualified in the area of ​​Clinical Analyzes and Cell Biology. With studies focused on Cancer Biology, she obtained the a Master's degree (2009-2011) and PhD (2012-2017), under the guidance of Dr. Miriam Galvonas Jasiulionis from the Department of Pharmacology, at Federal University of São Paulo (UNIFESP). The main related themes are: tumor progression models (murine and human), melanoma, epigenetic mechanisms (DNA methylation and modifications in histone), cancer stem cells and sustained stress conditions. Sge also has large experience in the field of Cellular and Molecular Biology. During her PhD, she participated in the BEPE program, by FAPESP, to develop new academic and scientific experiences in Dr. Meenhard Herlyn's laboratory at the Wistar Institute, Philadelphia, USA.Currently, acts as a R&D analyst at Recepta Biopharma, assisting in the development of a pipeline of new oncology drugs, as well as she has been participating on the elaboration and follow-up of the clinical studies promoted by the company. (Source: Lattes Curriculum)
- Research in the early stages of melanoma genesis of key regulators of epithelial-mesenchymal transition and stem cell-like phenotype epigenetically controlled, BP.DR
Abstract
Although less prevalent among skin cancers, cutaneous melanoma represents the most dangerous form and is responsible for most deaths associated with skin cancer. Primary cutaneous melanoma is often curable when early diagnosed. However, its extreme clinical metastatic melanoma detains the worst prognosis and remains one of the most resistant tumor types. It is known that the loss of the...
- Identification of genes that present altered expression due to aberrant promoter methylation in the initial phases of melanoma progression, BP.MS
- Identification of important targets associated with stem-like state and epithelial mesenchymal transition along melanocyte malignant transformation, BE.EP.DR
Abstract
Melanoma is an aggressive form of skin cancer that is responsible for the vast majority of skin cancer deaths and its incidence continues to increase worldwide. It is known the existence of many factors that contribute to melanoma development and to increase its incidence, however, there are many questions to be elucidated about the genetics, epigenetics and metabolomics changes that oc...
| 3 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 4 / 3 | All Scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 2 |
| Citations | 31 |
| Cit./Article | 15.5 |
| Data from Web of Science | |
MELO, FABIANA H. M.; MOLOGNONI, FERNANDA; MORAIS, ALICE S.; TORICELLI, MARIANA; MOURO, MARGARETH G.; HIGA, ELISA M. S.; LOPES, JOSE D.; JASIULIONIS, MIRIAM G.. Endothelial nitric oxide synthase uncoupling as a key mediator of melanocyte malignant transformation associated with sustained stress conditions. Free Radical Biology and Medicine, v. 50, n. 10, p. 1263-1273, MAY 15 2011. Web of Science Citations: 10. (06/61293-1, 09/03335-8)
MOLOGNONI, FERNANDA; CRUZ, ADRIANA T.; MELISO, FABIANA M.; MORAIS, ALICE S.; SOUZA, CAMILA F.; XANDER, PATRICIA; BISCHOF, JARED M.; COSTA, FABRICIO F.; SOARES, MARCELO B.; LIANG, GANGNING; et al. Epigenetic reprogramming as a key contributor to melanocyte malignant transformation. Epigenetics, v. 6, n. 4, p. 451-465, APR 2011. Web of Science Citations: 21. (06/61293-1, 09/03335-8)