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Jorge Elias Kalil Filho

CV Lattes ResearcherID ORCID


Universidade de São Paulo (USP). Faculdade de Medicina (FM)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Jorge Kalil is Professor of Clinical Immunology and Allergy and Director of the Laboratory of Immunology at the Heart Institute (InCor), School of Medicine, University of São Paulo (FMUSP), Brazil. He is Adjunct Professor at the George Washington University, DC and at the Case Westen Reserve University, Cleveland. He represents Brazil in the International Institute of Genetic Engineering and Biotechnology (ICGEB) and a member of the Brazilian Academy of Sciences since 1995. Since 2001, he coordinates iii-Institute for Investigative Immunology, a National Institute linked to the Ministry of Science and Technology, in Brazil. In addition, he co-chairs the Federation of Clinical Immunology Societies - FOCIS Center of Excellence in São Paulo and he coordinates the board of the USP Pasteur Institute?s board since 2018. He is member of the DSMB for phase 3 clinical trials of vaccines anti COVID supported by the US government. Kalil graduated in Medicine in Brazil (1977), has a Master?s degree in Immunology and Immunogenetics and is Doctor of Science in Human Biology, both from the University of Paris VII, while working at Jean Dausset?s laboratory (Dr. Dausset, Nobel Prize in 1980 for the discovery of HLA). He studies the mechanisms of immune recognition and distinction of self and no self. He contributed to the understanding of T-cell allorecognition, rejection and tolerance mechanisms in organ transplantation. He was pioneer in the rethinking of antibodies and graft rejection and disfunction, and also described the mechanism of how microbes induce breakage of tolerance to self, leading to autoimmune diseases in humans. He is currently developing vaccines against COVID-19 Streptococcus, HIV, Dengue and Zika in advanced scientific stage. His academic production registers more than 600 entries indexed by the Web of Science and more than 8,000 quotations. He is the holder of several patents. Kalil spent a sabbatical year as a Visiting Professor and Co-Director of the HLA laboratory, Department of Pathology, at the Stanford School of Medicine (1991) and was International Scholar of the Howard Hughes Medical Institute (1991-1995). He stayed one year in Boston as ?Distinguished Visiting Professor? at Harvard Medical School, Evergrande Institute of Immunological Diseases(2018-2019). He was President of the Heart Institute (InCor) (2006-2008) and also Chairman of the board of its support Foundation Zerbini (2006-2017), Director of the Butantan Institute and Chairman of the Board of its Foundation (2011-2017), President of the International Union of Immunological Societies (2013-2016). He was founder and first President of the Brazilian Association of Organ Transplantation, founder and Vice President of the Latin American Association of Immunology, President of the Brazilian Society of Immunology, and Head of the Department of Internal Medicine of the FMUSP. He also chaired the XIII International Congress of Immunology and was President of the International Union of Immunological Societies (IUIS) (2013-2016). He served as Special Advisor to Minister Adib Jatene in the matter of immunobiologicals (1993-1995). Kalil was decorated by the President of Brazil as Commander and later with the Great Cross of the Brazilian Order of Scientific Merit, and by the President of France as ?Chevalier? of the National Order of Merit. Among the awards received , the World Award in Biology from the Academy of Sciences of the Developing Countries (TWAS) in 2005, and the Science Award of the Conrado Wessel Foundation in 2011. In 2013 he received the Legislative Medal of Merit, granted by the Brazilian Congress and in 2016 the Medal of Victory, for ?the defense of freedom and world peace. He is Doctor Honoris causa by Sorbonne Universités, Paris, France and from Universidade Federal do Rio Grande do Sul (Brazil). He has been nominated Fellow of the Royal College of Physicians (FRCP) and got the Honorary membership of ASTMH (2015). (Source: Lattes Curriculum)

Articles published in Pesquisa FAPESP Magazine about the researcher:
Una carrera de obstáculos 
Obstacle course 
The puzzle of immunity 
Standing alone 
El rompecabezas de la inmunidad 
Para caminar por sus propios medios 
Allergies make us moody 
Las alergias alteran el humor 
Articles published in Pesquisa para Inovação FAPESP about the researcher:
FAPESP-funded startups are developing COVID-19 vaccines  
News published in Agência FAPESP Newsletter about the researcher
Articles published in other media outlets (0 total):
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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (19)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications15
Citations72
Cit./Article4.8
Data from Web of Science

ALMEIDA, RAFAEL RIBEIRO; ROSA, DANIELA SANTORO; RIBEIRO, SUSAN PEREIRA; SANTANA, VINICIUS CANATO; KALLAS, ESPER GEORGES; SIDNEY, JOHN; SETTE, ALESSANDRO; KALIL, JORGE; CUNHA-NETO, EDECIO. Broad and Cross-Clade CD4(+) T-Cell Responses Elicited by a DNA Vaccine Encoding Highly Conserved and Promiscuous HIV-1 M-Group Consensus Peptides. PLoS One, v. 7, n. 9, . Web of Science Citations: 19. (06/50096-0, 08/57881-0, 04/15856-9)

SILVA, ROSEMEIRE A.; GIORDANO, RICARDO J.; GUTIERREZ, PAULO S.; ROCHA, VIVIANE Z.; RUDNICKI, MARTINA; KEE, PATRICK; ABDALLA, DULCINEIA S. P.; PUECH-LEAO, PEDRO; CARAMELLI, BRUNO; ARAP, WADIH; et al. CTHRSSVVC Peptide as a Possible Early Molecular Imaging Target for Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 17, n. 9, . Web of Science Citations: 0. (04/02721-8)

MARTINS, CARLO DE OLIVEIRA; DEMARCHI, LEA; FERREIRA, FREDERICO MORAES; ALBERTO POMERANTZEFF, PABLO MARIA; BRANDAO, CARLOS; SAMPAIO, RONEY ORISMAR; SPINA, GUILHERME SOBREIRA; KALIL, JORGE; CUNHA-NETO, EDECIO; GUILHERME, LUIZA. Rheumatic Heart Disease and Myxomatous Degeneration: Differences and Similarities of Valve Damage Resulting from Autoimmune Reactions and Matrix Disorganization. PLoS One, v. 12, n. 1, . Web of Science Citations: 1. (08/57881-0)

GIAVINA-BIANCHI, MARA; NACAGAMO SOTTO, MIRIAN; GIAVINA-BIANCHI, PEDRO; MUNHOZ, RODRIGO; FESTA NETO, CYRO; KALIL, JORGE. Inter- and intra-patient heterogeneity of PD-L1 expression in metastatic melanomas: A retrospective study. AUSTRALASIAN JOURNAL OF DERMATOLOGY, v. 62, n. 2, . Web of Science Citations: 0. (17/20928-9)

GIAVINA-BIANCHI, MARA HUFFENBAECHER; FESTA-NETO, CYRO; SANCHES, JOSE ANTONIO; TEIXEIRA, MONICA LA PORTE; WALDVOGEL, BERNADETTE CUNHA. Worse survival of invasive melanoma patients in men and ``de novo{''} lesions'. ANAIS BRASILEIROS DE DERMATOLOGIA, v. 95, n. 2, p. 158-164, . Web of Science Citations: 0. (17/20928-9)

DIAS, MARINA M.; MORENO, ADRIANA S.; MAIA, LUANA S. M.; NUNES, FERNANDA LEONEL; CAMPOS, WAGNER N.; FERRIANI, MARIANA P. L.; SILVA, JR., WILSON A.; ARRUDA, L. KARLA. A cost-effective algorithm for diagnosis of hereditary angioedema with normal C1 inhibitor: Applying molecular approach to clinical practice. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, v. 8, n. 1, p. 419+, . Web of Science Citations: 0. (14/50890-5)

OUARHACHE, MARYEM; MARQUET, SANDRINE; FRADE, AMANDA FARAGE; FERREIRA, ARIELA MOTA; IANNI, BARBARA; ALMEIDA, RAFAEL RIBEIRO; SILVA NUNES, JOAO PAULO; PINTO FERREIRA, LUDMILA RODRIGUES; RIGAUD, VAGNER OLIVEIRA-CARVALHO; CANDIDO, DARLAN; et al. Rare Pathogenic Variants in Mitochondrial and Inflammation-Associated Genes May Lead to Inflammatory Cardiomyopathy in Chagas Disease. JOURNAL OF CLINICAL IMMUNOLOGY, v. 41, n. 5, . Web of Science Citations: 0. (13/50302-3, 14/50890-5)

OUARHACHE, MARYEM; MARQUET, SANDRINE; FRADE, AMANDA FARAGE; FERREIRA, ARIELA MOTA; IANNI, BARBARA; ALMEIDA, RAFAEL RIBEIRO; SILVA NUNES, JOAO PAULO; PINTO FERREIRA, LUDMILA RODRIGUES; RIGAUD, VAGNER OLIVEIRA-CARVALHO; CANDIDO, DARLAN; et al. Rare Pathogenic Variants in Mitochondrial and Inflammation-Associated Genes May Lead to Inflammatory Cardiomyopathy in Chagas Disease. JOURNAL OF CLINICAL IMMUNOLOGY, v. 41, n. 5, p. 1048-1063, . Web of Science Citations: 0. (14/50890-5, 13/50302-3)

DE-PAULA, VANESSA J.; DOS SANTOS, CARLA CRISTINE C.; LUQUE, MARIA CAROLINA A.; ALI, TACCYANA M.; KALIL, JORGE E.; FORLENZA, ORESTES V.; CUNHA-NETO, EDECIO. Acute and chronic lithium treatment increases Wnt/beta-catenin transcripts in cortical and hippocampal tissue at therapeutic concentrations in mice. METABOLIC BRAIN DISEASE, v. 36, n. 1, . Web of Science Citations: 0. (14/50890-5, 11/19892-3, 09/52825-8, 16/01302-9)

GIAVINA-BIANCHI, MARA; GIAVINA-BIANCHI, PEDRO; SOTTO, MIRIAN NACAGAMO; RODIG, SCOTT; MIHM, JR., MARTIN; FESTA NETO, CYRO; DUNCAN, LYN M.; KALIL, JORGE. Nodular primary cutaneous melanoma is associated with PD-L1 expression. EUROPEAN JOURNAL OF DERMATOLOGY, v. 30, n. 4, p. 352-357, . Web of Science Citations: 1. (17/20928-9)

ALMEIDA, RAFAEL RIBEIRO; RAPOSO, RUI ANDRE SARAIVA; COIRADA, FERNANDA CAROLINE; DA SILVA, JAMILE RAMOS; DE SOUZA FERREIRA, LUIS CARLOS; KALIL, JORGE; NIXON, DOUGLAS F.; CUNHA-NETO, EDECIO. Modulating APOBEC expression enhances DNA vaccine immunogenicity. Immunology and Cell Biology, v. 93, n. 10, p. 868-876, . Web of Science Citations: 3. (06/50096-0, 08/57881-0, 04/15856-9)

SANTANA, VINICIUS CANATO; ALMEIDA, RAFAEL RIBEIRO; RIBEIRO, SUSAN PEREIRA; DE SOUZA FERREIRA, LIUS CARLOS; KALIL, JORGE; ROSA, DANIELA SANTORO; CUNHA-NETO, EDECIO. Co-administration of plasmid-encoded granulocyte-macrophage colony-stimulating factor increases human immunodeficiency virus-1 DNA vaccine-induced polyfunctional CD4(+) T-cell responses. Memórias do Instituto Oswaldo Cruz, v. 110, n. 8, p. 1010-1016, . Web of Science Citations: 6. (06/50096-0, 08/57881-0, 04/15856-9)

PINTO FERREIRA, LUDMILA RODRIGUES; FRADE, AMANDA FARAGE; BARROS SANTOS, RONALDO HONORATO; TEIXEIRA, PRISCILA CAMILLO; BARON, MONIQUE ANDRADE; NAVARRO, ISABELA CUNHA; BENVENUTI, LUIZ ALBERTO; FIORELLI, ALFREDO INACIO; BOCCHI, EDIMAR ALCIDES; STOLF, NOEDIR ANTONIO; et al. MicroRNAs miR-1, miR-133a, miR-133b, miR-208a and miR-208b are dysregulated in Chronic Chagas disease Cardiomyopathy. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 175, n. 3, p. 409-417, . Web of Science Citations: 33. (13/50302-3, 08/57881-0, 12/08107-6)

PIERI‚ P.C.; PEREIRA‚ D.H.; GLINA‚ S.; HALLAK‚ J.; MCELREAVEY‚ K.; MOREIRA-FILHO‚ C.A.. A cost-effective screening test for detecting AZF microdeletions on the human Y chromosome. GENETIC TESTING, v. 6, n. 3, p. 185-194, .

CHEVILLARD, CHRISTOPHE; NUNES, JOAO PAULO SILVA; FRADE, AMANDA FARAGE; ALMEIDA, RAFAEL RIBEIRO; PANDEY, RAMENDRA PATI; NASCIMENTO, MARILDA SAVOIA; KALIL, JORGE; CUNHA-NETO, EDECIO. Disease Tolerance and Pathogen Resistance Genes May Underlie Trypanosoma cruzi Persistence and Differential Progression to Chagas Disease Cardiomyopathy. FRONTIERS IN IMMUNOLOGY, v. 9, . Web of Science Citations: 3. (13/50302-3, 14/50890-5, 16/15209-0)

TANNO, LUCIANA KASE; KERR, DANIEL SHIKANAI; DOS SANTOS, BERNARDO; TALIB, LEDA LEME; YAMAGUTI, CELIA; RODRIGUES, HELCIO; GATTAZ, WAGNER FARID; KALIL, JORGE. The Absence of CYP3A5{*}3 Is a Protective Factor to Anticonvulsants Hypersensitivity Reactions: A Case-Control Study in Brazilian Subjects. PLoS One, v. 10, n. 8, . Web of Science Citations: 6. (11/22748-1)

VINICIUS CANATO SANTANA; RAFAEL RIBEIRO ALMEIDA; SUSAN PEREIRA RIBEIRO; LUÍS CARLOS DE SOUZA FERREIRA; JORGE KALIL; DANIELA SANTORO ROSA; EDECIO CUNHA NETO. Co-administration of plasmid-encoded granulocyte-macrophage colony-stimulating factor increases human immunodeficiency virus-1 DNA vaccine-induced polyfunctional CD4+ T-cell responses. Memórias do Instituto Oswaldo Cruz, v. 110, n. 8, p. -, . (06/50096-0, 08/57881-0, 04/15856-9)

GRAUDENZ‚ GS; LATORRE‚ M.; TRIBESS‚ A.; OLIVEIRA‚ CH; KALIL‚ J.. Persistent allergic rhinitis and indoor air quality perception-an experimental approach. INDOOR AIR, v. 16, n. 4, p. 313-319, .

MARA HUFFENBAECHER GIAVINA-BIANCHI; CYRO FESTA-NETO; JOSE ANTONIO SANCHES; MONICA LA PORTE TEIXEIRA; BERNADETTE CUNHA WALDVOGEL. Worse survival of invasive melanoma patients in men and "de novo" lesions,. ANAIS BRASILEIROS DE DERMATOLOGIA, v. 95, n. 2, p. 158-164, . (17/20928-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FERREIRA, Susanne Carolinne Penha. Detecção de estruturas renais reconhecidas por anticorpos não-HLA envolvidos na rejeição humoral em pacientes transplantados renais. Dissertação (Mestrado) -  Faculdade de Medicina.  Universidade de São Paulo (USP).  São Paulo.  (06/51866-4

LUQUE, Maria Carolina Aquino. Papel de CD100 na patogênese da aterosclerose. Tese (Doutorado) -  Faculdade de Medicina.  Universidade de São Paulo (USP).  São Paulo.  (06/53325-0

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