Abstract
Sickle cell anemia (SCA) is a hemoglobinopathy resulting from a homozygous mutation in the seventh codon of the beta-globin gene. However, there is extensive clinical variability, with systemic involvement. Neurological changes are common, and it has been related to the greater severity of the disease, being fatal in 15% of cases. Transient ischemic accidents, infarctions and cerebral hem…