Ariane Fidelis Busso Lopes

• Abstract

  The role of Matrix Metalloproteinases (MMPs) in the degradation and extracellular matrix remodeling is but one aspect of the role played by this family of proteases that has 27 members. Once activated, the MMPs cleave substrates such as matrix proteins, proinflammatory mediators, and growth factors, which will activate several signaling pathways that depend on MAP kinases, and are importa…

  Multiplex N-terminomics analysis of cardiomyocyte secretome based on MMP-2 and ADAM17 activity using TMT-TAILS quantitative proteomics, BP.PD

• Abstract

  Head and neck cancer is the sixth most common malignancy in the world. The five-year survival is 50% of cases and poor prognosis is directly related to the development of regional lymph node metastases. Several molecular markers of prognosis have been reported in the literature for head and neck tumors, but none of them is currently used in clinical practice. This project was designed to …

  Proteomic analysis of the invasive front in head and neck squamous cell carcinomas with regional metastasis, BP.PD

• Abstract

  Penile cancer is a rare malignancy that occurs predominantly in men after the sixth decade of life. Molecular genetic data in penile cancer are extremely limited. This project was approved by FAPESP in Master degree (Process 2009/068511-7) and the thesis was presented to the Defense Counsel; however, the Committee members suggested, unanimously, the promotion to PhD. For the purpose of da…

  Tumoral markers detected by copy number variation analysis (aCGH) and large scale gene expression profiling in penile carcinomas, BP.DD

(Only some records are available in English at this moment)

• Abstract

  The presence of lymph node metastasis is a major prognostic factor affecting patients with head and neck squamous cell carcinoma (HNSCC). Although advances have been made in the field of regional metastasis, limited data are available for the molecular signals involved in this process. In our FAPESP post-doctorate project (Process 2015/19191-6), we identified a set of proteins in the prim…

  Intravital two-photon microscopy of the lymph nodes to understand the role of extracellular vesicles in immune system dynamics, BE.EP.PD

• Abstract

  Lymph node metastasis is the main prognostic factor in patients with head and neck squamous cell carcinoma (HNSCC), and can decrease the 5-year survival rates to lower than 50%. The molecular signals involved in this complex process are poorly characterized for HNSCC, and no molecular markers are currently used in clinical practice. In this context, our FAPESP post-doctorate fellowship pr…

  Proteomics analysis of the invasive front and lymph node in head and neck squamous cell carcinomas using MALDI-imaging mass spectrometry, BE.EP.PD