CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
doctorate at Biochemistry from Universidade Estadual de Campinas (1995). Has experience in Physiology, focusing on General Physiology, acting on the following subjects: secreção de insulina, gene expression, gene frequency, prolactina and sinalização intracelular. (Source: Lattes Curriculum)
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Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected t…
Dynamic metabolic regulation by the liver is essential for the maintenance of energy metabolism and the organism survival. During fasting, the liver produces glucose to supply the metabolic demand of the organism. Recently, we have demonstrated that rats born to dexamethasone-treated mothers do not increase hepatic glucose production adequately when subjected to prolonged fasting, which i…
Pregnancy is a period of physiological insulin resistance, where the increase in both pancreatic beta cell mass and insulin secretory capacity preserves the maternal normoglycemia. After the gestational increase in the mass and activity, a rapid involution of the endocrine pancreas takes place in the beginning of post-partum period. This phenomenon constitutes one the mechanisms that avoi…
Fructose-enriched diets are known to cause several metabolic adaptations associated with metabolic syndrome such as increased fasting glycemia, insulin resistance and increased circulating triglycerides with hepatic steatosis. Many studies describe that fructose causes hepatic insulin resistance and increase of gluconeogenesis through mechanisms yet unknown. The importance of extra-hepati…
(Only some records are available in English at this moment)
Injectable analogs of GLP-1 and GLP-2 are commonly used for the treatment of obesity type 2diabetes mellitus (T2DM). Currently, applications of these hormones in the form of the peptideitself are limited due to their short half-life. The oral administration of a therapeutic peptide (TP) represents a significant biomedical advancement, yet it faces challenges related to gastrointestinalins…
The importance of the transcription factor TCF7L2 on the function of beta cells is mainly studied in type 2 diabetes mellitus, and its role in the context of the adaptation of these cells during pregnancy is still poorly explored. Thus, the objective of this work is to evaluate the effect of the gestational hormones progesterone (P4) and 17²-estradiol (E2) on the adaptation of the beta ce…
The increasing prevalence of Obesity has assumed characteristics of a pandemic that is directly associated with the risk of developing Hypertension, cardiovascular disease, Dyslipidemia, Type 2 Diabetes Mellitus (T2DM) and Non-Alcoholic Fatty Liver Disease (NAFLD). Such comorbidities make Obesity contribute to reduced life expectancy. It is known that excess of adipose tissue is accompani…
Preterm birth is associated with higher risk of metabolic and cardiovascular disorders as well as Hypercholesterolemia and Atherosclerosis in mothers over the course of life. The role of miRNAs in this model is not yet characterized, but it is known that the miR-33 family controls ABCA1 and ABCG1 genes, involved in lipid metabolism, and exosome levels of miR-92 may interfere with brown ad…
Consumption of beverages artificially sweetened with fructose has been increasing in Western society since the 1970s. In parallel to this eating behavior, recent epidemiological data show an increase in the incidence of asthma in children born to mothers who consume excessive amounts of fructose-sweetened drinks during pregnancy. Despite this epidemiological correlation, it has not been e…
In order to investigate the effects of prenatal treatment with dexamethasone on blood pressure and maternal and offspring cardiac function, and the molecular mechanisms involved in these changes, Caudal Blood Pressure (CBP) of virgin Wistar rats, aged 60 days, will be monitored by tail plethysmography. After completing 90 days, the rats will be randomly assigned to four groups: virgin rat…
(Only some records are available in English at this moment)
The present proposal will be developed to expand the objectives of the original project that is being developed in Brazil (fellowship granted by FAPESP in Brazil - 2020/06397-3 - University of Sao Paulo), aiming to evaluate the role of advanced glycation end products (AGEs) in the cellular senescence of pancreatic beta cell of obese mice and mice with history of obesity. The aim is to tak…
The inflammatory response of allergic asthma is classically recognized as a predominantly TH2 activation that leads to IgE production and eosinophil development and infiltration in the lung parenchyma. Platelets also play a pivotal role in the inflammatory as evidenced by studies in which platelet depletion by reduced leukocyte accumulation in tissues in response to specific allergen expo…
Several studies have demonstrated the deleterious effects of the maternal obesity on the metabolism of the offspring including accelerating the onset of conditions traditionally associated with ageing, as type 2 diabetes. On the last years, Ozanne´s group has found the participation of an accelerated celular senescence process on the offspring of obese mothers. More recently, skeletal mus…
| 1 / 1 | Ongoing grants |
| 13 / 8 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 29 / 14 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 49 / 29 | All research grants and scholarships |
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