Silvana Auxiliadora Bordin da Silva
CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
doctorate at Biochemistry from Universidade Estadual de Campinas (1995). Has experience in Physiology, focusing on General Physiology, acting on the following subjects: secreção de insulina, gene expression, gene frequency, prolactina and sinalização intracelular. (Source: Lattes Curriculum)
- OCRC - Obesity and Comorbidities Research Center, AP.CEPID
Abstract
Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected...
- Mechanisms involved in the late-onset pancreatic beta cell disfunction induced by maternal glucocorticoid excess at the end of pregnancy, AP.R
Abstract
Pregnancy is a period of physiological insulin resistance, where the increase in both pancreatic beta cell mass and insulin secretory capacity preserves the maternal normoglycemia. After the gestational increase in the mass and activity, a rapid involution of the endocrine pancreas takes place in the beginning of post-partum period. This phenomenon constitutes one the mechanisms that av...
- Potential role of hypothalamic AMPK for fructose-induced modulation of gluconeogenesis, AP.R
Abstract
Fructose-enriched diets are known to cause several metabolic adaptations associated with metabolic syndrome such as increased fasting glycemia, insulin resistance and increased circulating triglycerides with hepatic steatosis. Many studies describe that fructose causes hepatic insulin resistance and increase of gluconeogenesis through mechanisms yet unknown. The importance of extra-hepa...
- Inflammation and immune response in obesity, AP.TEM
Abstract
Obesity results from the progressive 1055 of the homeostatic control of food intake and energy expenditure. Genetic and environmental factors contribute for the complex pathogenesis of this disease. However, in spite of the considerable advance obtained in the understanding of the mechanisms involved in the control of hunger and thermogenesis, this has provided no major breakthrough in ...
(Only some records are available in English at this moment)
- Effect of PPAR-gamma or PPAR-alpha agonists on the metabolic programing induced by maternal caloric restriction, BP.DR
Abstract
Caloric Restriction of 50% (CR) during the third week of rat pregnancy increases corticosterone levels and adrenal weight. The corticosterone excess programs several changes in the offspring such as arterial stiffness and glucose intolerance. The programming of vascular changes induced by CR can be avoided with drugs that blunt corticosterone synthesis during pregnancy. However, it is n...
- Epigenetic regulation of PGC-1a expression in the liver of offspring subjected to antenatal exposure to glucocorticoids, BP.IC
Abstract
PGC-1a (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha) is an efficient regulator of the energy metabolism. This transcription co-activator stimulates the mitochondrial biogenesis in skeletal muscle, thermogenesis in brown adipose tissue and the expression of gluconeogenesis enzymes in the liver. The multiple actions of PGC-1a are warranted by its ability to bind ...
- Hepatic microRNA expression profile in Goto-Kakizaki rats and wistar rats subjected to metabolic programming by prenatal exposure to glucocorticoid excess, BP.DR
Abstract
In the last years there is a crescent number of evidences suggesting the role of epigenetic factors in the pathogenesis of type 2 diabetes (T2D). However, the current understanding of the molecular mechanisms that connect the environmental and genetic factors is still limited. The Wistar rat strain Goto-Kakizaki (GK) is considered one of the best animal models of T2D because it shows si...
- Endocrine pancreas maturation and differentiation in offspring of females submitted to dexamethasone treatment during pregnancy, BP.PD
Abstract
The restriction of intrauterine growth resulting in low birth weight, is considered an important risk factor for the later development of metabolic diseases. Several epidemiological studies have shown a link between low birth weight susceptibility to developing type 2 diabetes, hypertension, cardiovascular disease and obesity later in life. Various models are used for the study of intra...
(Only some records are available in English at this moment)
- Involvement of microRNAs on the accelerated ageing process caused by obesity, BE.EP.PD
Abstract
Several studies have demonstrated the deleterious effects of the maternal obesity on the metabolism of the offspring including accelerating the onset of conditions traditionally associated with ageing, as type 2 diabetes. On the last years, Ozanne´s group has found the participation of an accelerated celular senescence process on the offspring of obese mothers. More recently, skeletal m...
| 1 / 1 | Ongoing research grants |
| 12 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 25 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 40 / 20 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 5 |
| Citations | 29 |
| Cit./Article | 5.8 |
| Data from Web of Science | |
FARIA, JULIANA DE ALMEIDA; DUQUE-GUIMARAES, DANIELLA; CARPENTER, ASHA A. M.; LOCHE, ELENA; OZANNE, SUSAN E.. A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue. SCIENTIFIC REPORTS, v. 7, MAR 24 2017. Web of Science Citations: 7. (14/17012-4, 14/20380-5)
FERNANDEZ-TWINN, DENISE S.; GASCOIN, GERALDINE; MUSIAL, BARBARA; CARR, SARAH; DUQUE-GUIMARAES, DANIELLA; BLACKMORE, HEATHER L.; ALFARADHI, MARIA Z.; LOCHE, ELENA; SFERRUZZI-PERRI, AMANDA N.; FOWDEN, ABIGAIL L.; et al. Exercise rescues obese mothers' insulin sensitivity, placental hypoxia and male offspring insulin sensitivity. SCIENTIFIC REPORTS, v. 7, MAR 14 2017. Web of Science Citations: 19. (14/20380-5)
DUQUE-GUIMARES, DANIELLA; OZANNE, SUSAN. Early nutrition and ageing: can we intervene?. BIOGERONTOLOGY, v. 18, n. 6, SI, p. 893-900, DEC 2017. Web of Science Citations: 3. (14/20380-5)
PAYOLLA, TANYARA B.; TEIXEIRA, CAIO J.; SATO, FABIO T.; MURATA, GILSON M.; ZONTA, GIZELA A.; SODRE, FRHANCIELLY S.; CAMPOS, CAROLINA V.; MESQUITA, FILIPHE N.; ANHE, GABRIEL F.; BORDIN, SILVANA. In Utero Dexamethasone Exposure Exacerbates Hepatic Steatosis in Rats That Consume Fructose During Adulthood. NUTRIENTS, v. 11, n. 9, SEP 2019. Web of Science Citations: 0. (13/07607-8, 14/08913-8, 15/25597-5)
MUSIAL, BARBARA; FERNANDEZ-TWINN, DENISE S.; DUQUE-GUIMARAES, DANIELLA; CARR, SARAH K.; FOWDEN, ABIGAIL L.; OZANNE, SUSAN E.; SFERRUZZI-PERRI, AMANDA N.. Exercise alters the molecular pathways of insulin signaling and lipid handling in maternal tissues of obese pregnant mice. PHYSIOLOGICAL REPORTS, v. 7, n. 16, AUG 2019. Web of Science Citations: 0. (14/20380-5)
BORDIN, SILVANA; AMARAL, MARIA E. C.; ANHÊ, GABRIEL F.; DELGHINGARO-AUGUSTO, VIVIANE; CUNHA, DANIEL A.; NICOLETTI-CARVALHO, JOSÉ E.; BOSCHERO, ANTONIO CARLOS. Prolactin-modulated gene expression profiles in pancreatic islets from adult female rats. Molecular and Cellular Endocrinology, v. 220, n. 1/2, p. 41-50, May 2004.
(References retrieved automatically from State of São Paulo Research Institutions)
GOMES, Patrícia Rodrigues Lourenço. Efeito da exposição à dexametasona sobre a expressão de miRNA no pâncreas endócrino e a homeostasia glicêmica de ratas prenhes.. 2015. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/01568-5)
RODRIGUES, Sandra Campos. Efeitos da pinealectomia e do bloqueio da sinalização do receptor de glicocorticoides sobre as funções metabólicas e inflamatórias hepáticas. 2015. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/12329-1)
ANHE, Fernando Forato. Regulação do perfil transcricional pelas SMADs 1, 5 e 8 em células b da linhagem INS1E.. 2010. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (07/56641-3)
CARVALHO, Jose Edgar Nicoletti. Mecanismos moleculares envolvidos na redução da proliferação de células beta pancreáticas induzida por glicocorticóides.. 2010. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (07/50964-5)
SANTOS, Camilo de Lellis. Alterações na expressão de Dexras1 mediada pela cooperação entre STAT5 e GR contribuem para modulação da secreção de insulina na gestação e lactação.. 2010. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (05/56976-0)
RODRIGUES, Sandra Campos. Avaliação funcional e molecular de adaptações no metabolismo energético hepático ao final do período de prenhez em ratas.. 2011. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (09/02651-3)