doctorate at Biochemistry from Universidade Estadual de Campinas (1995). Has experience in Physiology, focusing on General Physiology, acting on the following subjects: secreção de insulina, gene expression, gene frequency, prolactina and sinalização intracelular. (Source: Lattes Curriculum)
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Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected t…
Dynamic metabolic regulation by the liver is essential for the maintenance of energy metabolism and the organism survival. During fasting, the liver produces glucose to supply the metabolic demand of the organism. Recently, we have demonstrated that rats born to dexamethasone-treated mothers do not increase hepatic glucose production adequately when subjected to prolonged fasting, which i…
Pregnancy is a period of physiological insulin resistance, where the increase in both pancreatic beta cell mass and insulin secretory capacity preserves the maternal normoglycemia. After the gestational increase in the mass and activity, a rapid involution of the endocrine pancreas takes place in the beginning of post-partum period. This phenomenon constitutes one the mechanisms that avoi…
Fructose-enriched diets are known to cause several metabolic adaptations associated with metabolic syndrome such as increased fasting glycemia, insulin resistance and increased circulating triglycerides with hepatic steatosis. Many studies describe that fructose causes hepatic insulin resistance and increase of gluconeogenesis through mechanisms yet unknown. The importance of extra-hepati…
(Only some records are available in English at this moment)
Consumption of beverages artificially sweetened with fructose has been increasing in Western society since the 1970s. In parallel to this eating behavior, recent epidemiological data show an increase in the incidence of asthma in children born to mothers who consume excessive amounts of fructose-sweetened drinks during pregnancy. Despite this epidemiological correlation, it has not been e…
In order to investigate the effects of prenatal treatment with dexamethasone on blood pressure and maternal and offspring cardiac function, and the molecular mechanisms involved in these changes, Caudal Blood Pressure (CBP) of virgin Wistar rats, aged 60 days, will be monitored by tail plethysmography. After completing 90 days, the rats will be randomly assigned to four groups: virgin rat…
The increasing prevalence of Obesity has assumed characteristics of a pandemic that is directly associated with the risk of developing Hypertension, cardiovascular disease, Dyslipidemia, Type 2 Diabetes Mellitus (T2DM) and Non-Alcoholic Fatty Liver Disease (NAFLD). Such comorbidities make Obesity contribute to reduced life expectancy. It is known that excess of adipose tissue is accompani…
Caloric Restriction of 50% (CR) during the third week of rat pregnancy increases corticosterone levels and adrenal weight. The corticosterone excess programs several changes in the offspring such as arterial stiffness and glucose intolerance. The programming of vascular changes induced by CR can be avoided with drugs that blunt corticosterone synthesis during pregnancy. However, it is not…
PGC-1a (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha) is an efficient regulator of the energy metabolism. This transcription co-activator stimulates the mitochondrial biogenesis in skeletal muscle, thermogenesis in brown adipose tissue and the expression of gluconeogenesis enzymes in the liver. The multiple actions of PGC-1a are warranted by its ability to bind to…
In the last years there is a crescent number of evidences suggesting the role of epigenetic factors in the pathogenesis of type 2 diabetes (T2D). However, the current understanding of the molecular mechanisms that connect the environmental and genetic factors is still limited. The Wistar rat strain Goto-Kakizaki (GK) is considered one of the best animal models of T2D because it shows simi…
(Only some records are available in English at this moment)
Several studies have demonstrated the deleterious effects of the maternal obesity on the metabolism of the offspring including accelerating the onset of conditions traditionally associated with ageing, as type 2 diabetes. On the last years, Ozanne´s group has found the participation of an accelerated celular senescence process on the offspring of obese mothers. More recently, skeletal mus…
| 1 / 1 | Ongoing research grants |
| 13 / 8 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 26 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 44 / 24 | All research grants and scholarships |
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CV Lattes
ORCID