graduation at Bacharelado Em Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1989), master's at General Biology from Universidade Estadual de Campinas (1992) and doctorate at Morphology from Universidade de São Paulo (1998). Has experience in Morphology, focusing on Cytology and Celular Biology, acting on the following subjects: prostate, diabetes, testis, high-fat diet and female prostate. (Source: Lattes Curriculum)
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The type and amount of dietary lipids can differentially affect the prostate and promote the development of prostate cancer (PCa). The protective role initially attributed to polyunsaturated fatty acids (PUFAs) - eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) - in PCa has been questioned in recent studies. We have observed a variable action of DHA on the proliferation of non-t…
This study compares the impact of obesogenic environment (OE) in six different periods of development on sperm parameters and the testicular structure of adult rats and their correlations with sex steroid and metabolic scenario. Wistar rats were exposed to OE in gestation (O1), gestation/lactation (O2), from weaning to adulthood (O3), from lactation to adulthood (O4), from gestation to se…
Experimental evidence indicates that diabetes leads to atrophy,proliferation and cell death imbalance and increase incidence of malignantand pre-malignant lesions in the prostate. The low androgen levels and changes in insulin signaling have been implicated in these responses, but the role of oxidative stress should be further clarified. The neurohormonemelatonin has been widely used in t…
(Only some records are available in English at this moment)
The modulation of autophagy may be an adjuvant in therapies for prostate cancer treatment. However, its role in cancer is complex and context-dependent, as autophagy can acts as a tumor suppressor in the early stages of tumor development or favors tumor progression in established or advanced tumors. Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid that affects apoptosis in prost…
Prostate Cancer (PCa) is a major public health problem, especially castration-resistant cancer (CRPC), whose treatment is still challenging. Experimental evidence indicates that consumption of the omega-3 (É-3) polyunsaturated fatty acid - docosahexaenoic acid (DHA) - reduces the risk of PCa, but this issue is still controversial in epidemiological studies. We have found that DHA delays t…
Prostate cancer (PCa) is one of the leading causes of death in men by cancer-related cases. Inflammation and diet directly affect the risk of developing PCa. Several reports show that docosahexaenoic acid, an omega-3 fatty acid, displays an anti-tumor effect on PCa, however, more studies are needed to clarify its effects on tumor progression. Annexin A1 (ANXA1), an anti-inflammatory prote…
Prostate cancer (PCa) is one of the five leading causes of death in male individuals on the world stage and a serious public health problem. Currently, it is know that diet and particularly that high lipid intake, as well as its nature, are implicated in the genesis of this disease. The marine omega-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexae…
Prostate is regulated by sexual steroids and influence of exogenous factors, such as diet, remain unknown. Several studies show that not only quantity, but lipid quality can influence intracellular homeostasis leading to carcinogenesis. Therefore, is known that prostate tumor cells change energetic metabolism from glycolysis to fatty acid oxidation. Docosahexaenoic acid (DHA) is an essent…
It is known that disturbances in maternal nutrition can lead to permanent adaptations in the physiology of various organs of offspring, but the consequences for the testis and male reproductive parameters are poorly understood. Recently obtained data showed that maternal obesity associated with the excess of unsaturated lipids in the diet reduces sperm production in rats in adulthood, sug…
(Only some records are available in English at this moment)
Phthalates are endocrine active substances (EAS) widely used as plasticizer. Among the EAS, di-ethylhexyl phthalate (DEHP) is a very relevant endocrine disruptor (ED) for human exposure. After absorption DEHP is rapidly hydrolyzed in mono-2-ethylhexyl phthalate (MEHP), its active metabolite. Many studies confirmed the reprotoxic effects of MEHP exposure on males, such as perturbations in …
Experimental diabetes leads to drastic prostatic atrophy and impairment of secretory capacity. This damage is associated with the imbalance in epithelial kinetics, remodeling of the extracellular matrix and morphofunctional changes in prostatic stromal cells. There was also increase incidence of intraepithelial neoplasia (PIN) and incidence of malignancies in the prostate after three mont…
| 8 / 5 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 25 / 20 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 38 / 30 | All research grants and scholarships |
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CV Lattes
ORCID