- Research Grants
graduation at Química Industrial from Universidade de Franca (2008), master's at Programa de Pós-Graduação em Ciências - Universidade de Franca from Universidade de Franca (2011) and doctorate at Pharmacy from Universidade de São Paulo (2015). (Source: Lattes Curriculum)
Cruzain, the main cysteine protease of Trypanosoma cruzi, is an essential enzyme for the life cycle of the parasite and has been used as a viable target for searching for enzyme inhibitors as drug candidates. The peptide mimetic compound K11777 inhibits cruzain at nanomolar concentrations, and acts by an irreversible inhibition mechanism. Analogs or derivatives K11777 usually contain el...
The objective of this project is the development of organometallic reagents for biological active molecules synthesis. In the first part of the work a number of bases such as TMPLi, TMPMgCl.LiCl, TMPZnCl.LiCl e TMP2Mg.2LiCl will be prepared and used in the functionalization of dioxinones. Aiming to develop more stable and selective bases, in the second part of the work some new bases de...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
(References retrieved automatically from State of São Paulo Research Institutions)
BATISTA, João Henrique Carvalho. Funcionalização dirigida de 2-oxazolinas e dioxinonas utilizando bases mistas de lítio-magnésio. 2015. Tese (Doutorado) – Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto.