Abstract
T-cell acute lymphoblastic leukemia (T-ALL) is a malignant neoplasm that accounts for 15% of cases in children and 25% in adults and is characterized by the uncontrolled proliferation of T- cells lymphocytes. From T-ALL cases described in literature, 25% of them are involved with the IL-7R pathway. Gain-of-function mutations in IL-7Ra were first described at the Boldrini Children`s Center…