- Research Grants
Dr. Fernanda Faião Flores worked as a postdoctoral fellow at Moffitt Cancer Center, Tampa, Florida, United States (2017-2019) and at School of Pharmaceutical Sciences - University of São Paulo, Brazil (2013-2017). She obtained her PhD in 2013 at School of Medicine - University of São Paulo, Brazil (2009-2013) on the investigation of the antiproliferative and cytotoxic effects of new compounds and therapies for cancer treatment. She held three months of her PhD at the University of Barcelona (Spain). Her career focus on the development and application of new therapies to cancer treatment and in vitro alternative methods to replace animal testing, human skin biology, mechanistic cell signaling and evaluation of pathways in distinct cell types. As a Postdoc in 2013-2017 at the University of Sao Paulo, at the Skin Biology group, the development of "in vivo like" human skin was her major interest with drug target therapies aiming melanoma treatment. In 2015-2016, she became a visiting Postdoc at the Moffitt Cancer Center in USA, and then in 2017-2019 as a Postdoctoral fellow of the same institution. Her main goal was to expand the research on melanoma therapy and the study of uveal melanoma, the most common and devastating form of eye cancer. She has also participated actively in the training of a number of junior lab members and a number of Moffitt, University of South Florida and University of Sao Paulo graduate students who have rotated through the labs. (Source: Lattes Curriculum)
Metastatic melanoma has intrinsic resistance as a central problem to be refractory to almost therapeutic interventions. Despite numerous attempts to treat melanoma, e.g. chemo-, radio- and immunotherapy, the patients survival rate remains with poor prognosis. RAF-type proteins are intermediates in the MAPK and RAS signaling pathways cascade and affect cell proliferation. Mutations in BR...
Melanoma is the most aggressive form of skin cancer and practically all patients treated with BRAF inhibitors acquire resistance after initial treatment by multifactorial escape mechanisms. The molecular chaperone heat shock protein-90 family plays a key role in maintaining the malignant potential of cancer cells and HSP90 client proteins are critical for melanoma progression, leading t...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|