Dr. Cristiano R. W. Guimarães received his Ph.D. in Theoretical/Organic Chemistry from the Federal University of Rio de Janeiro in 2001 under the supervision of Prof. Ricardo Bicca de Alencastro, followed by a post-doctorate on modeling of enzymatic reactions and computer-aided drug design with Prof. William Jorgensen at Yale University. He first worked at Amgen and then Pfizer, both in the US, as a Senior Principal Scientist. In 2014, Dr. Guimarães returned to Brazil to lead the Radical Innovation Unit at Aché Laboratórios Farmacêuticos. Dr. Guimarães left Aché in early 2021 to start a biotech in Brazil called Nintx (Next Innovative Therapeutics). Throughout his career, Dr. Guimarães received several national and international distinctions and authored 70 publications and patents. Due to the impact of his work, Dr. Guimarães is among the Top 2 percent most influential scientists in the world according to Elsevier. (Source: Lattes Curriculum)
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Multifactorial diseases, such as metabolic disorders and inflammatory bowel diseases, are caused by genetic, environmental, and interactional factors, which can be mediated by the human microbiome. Alterations in the interspecies balance in the human gut (dysbiosis) are linked to many pathologies, being more relevant in situations where the intestinal barrier is compromised. This allows f…
Multifactorial diseases, such as metabolic diseases, cancer and inflammatory bowel diseases, are caused by genetic and environmental factors and interactions between them, sometimes mediated by the human microbiome. The change in the interspecies balance in the human intestine (dysbiosis) is linked to many pathologies, being more relevant in situations where the intestinal barrier is comp…
No PIPE-I, estamos em etapa de finalização da prova de conceito de um protocolo que simula a condição de permeabilidade intestinal em uma monocamada de células Caco2, além da integração com nossa plataforma de simulação da microbiota intestinal. O projeto PIPE-II indireto propõe continuar avançando na ampliação dos modelos celulares, integração entre os modelos que simulam a microbiota e …
A integridade da barreira intestinal é mantida por um conjunto de proteínas localizado entre as células epiteliais, chamadas de proteínas de junções apertadas, que forma uma barreira física e controla a permeabilidade paracelular. A alteração na homeostase das proteínas de junções apertadas, que leva ao leaky gut, é um fator central em doenças multifatoriais, que por sua vez, por conta do…
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