CV Lattes
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ORCID
Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. Instituto de Ciência e Tecnologia (ICT) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Biologia from Pontifícia Universidade Católica do Paraná (2004), master's at Physiology from Universidade de São Paulo (2006) and doctorate at Biochemistry from Universidade de São Paulo (2011). (Source: Lattes Curriculum)
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Melanoma is an aggressive skin cancer and a lethal melanocytic neoplasm, with increasing annual number of cases (faster than any other solid tumor). Since the protein composition (proteome) of tumoral cells may be regarded as a description of cellular status, the evaluation of protein expression patterns in biopsy samples may lead to the discovery of cancer-related markers and new drug ta…
The search for biomarkers has been addressed by several investigators in the field of cancer biology, however, given the multitude of etiologic factors associated to oncogenesis, a number of challenges still need to be overcome. The imbalance of cellular homeostasis during oncogenesis has a marked effect on the repertoire of the proteins secreted by malignant cells (cellular secretome), a…
The search for cancer biomarkers is a field in which a large amount of human and financial resources are concentrated, both from private and public research around the world. Experimental approaches in proteomics related to the prospection of biomarkers aim to find specific proteins, characteristic expression patterns, or markers of tumor progression. In a recent study on the proteolytic …
The high energy demand imposed by the oncogenic process has important consequences on the metabolism of transformed cells, as well as an expressive impact on the diagnostic methods and therapies associated with the treatment of neoplasia. Mannose is an epimer of glucose and therefore is absorbed by the same transporters as glucose. Recent work using tumor cell lines has demonstrated that …
The search for biomarkers has been the focus of a number of studies in tumor biology, however, given the etiological diversity of factors associated with oncogenesis, few candidates have been identified so far. The imbalance in cellular homeostasis caused by oncogenesis has an expressive effect on the repertoire of proteins present in tumor cells, as well as on the physiological events re…
(Only some records are available in English at this moment)
Protein kinase-mediated phosphorylation is a ubiquitous post-translational modification (PTM) that regulates signal transduction pathways in metazoans. The biological effects of protein phosphorylation are diverse, ranging from subcellular localization and structural changes to turnover. With more than 550 kinases described so far and spanning almost 2% of the human genes, the protein kin…
The search for cancer biomarkers is a field in which a large amount of human and financial resources is concentrated, both from private and public research around the world. Experimental approaches in proteomics related to the prospection of biomarkers aim to find specific proteins, characteristic expression patterns, or markers of tumor progression. In a recent study on the proteolytic p…
The search for biomarkers has been addressed by several investigators in the field of cancer biology, however, given the multitude of etiologic factors associated to oncogenesis, a number of challenges still need to be overcome. The imbalance of cellular homeostasis during oncogenesis has a marked effect on the repertoire of the proteins secreted by malignant cells (cellular secretome), a…
Proteinases are the major components of viperid venom proteomes. In this context, snake venom metalloproteinases (SVMPs) are among the most abundant enzymes found in venoms and are responsible for several of the pathological effects of envenomation. The structural similarity of SVMPs with ADAMs (A Disintegrin and Metalloproteinase) and ADAMTSs (A Disintegrin and Metalloproteinase with Thr…
| 2 / 2 | Completed research grants |
| 8 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 14 / 12 | All research grants and scholarships |
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