CV Lattes
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Sociedade Beneficente de Senhoras (SBSHSL). Hospital Sírio-Libanês (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at BIOLOGY from Universidade de São Paulo (2003), master's (2006) and doctorate (2011) at IMMUNOLOGY from Instituto de Ciências Biomédicas - USP (2006). PhD Sandwich at Université François Rabelais, Tours (2009), and at Faculté de Médecine Xavier Bichat, Paris (2009), France. Post doctorate at CSC/MRC Imperial College, London (2015), United Kingdom and at Instituto de Ciências Biomédicas da USP (2017). Currently Research Scientist at Instituto de Ensino e Pesquisa - Hospital Sírio-Libanês.Has experience in Immunology, focusing on myeloid cells modulation, mTOR pathway, kidney diseases, transplantation, sepsis and cancer. (Source: Lattes Curriculum)
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Macrophages are immune system cells that are found in all tissues and have phagocytosis as one of their main activities. These cells can have different activation phenotypes depending on the microenvironment composition they are in. An important receptor present in these cells is TLR4, which recognizes patterns such as LPS and other endogenous antigens. Agonists action in this pathway res…
Acute myeloid leukemia (AML) is a complex hematological cancer that mainly affects elderly patients (over 60 years old) and these patients are the ones that have worst response to current treatments. Thus, there is a great need for new therapeutic alternatives for this cancer. In the last decade, the BRD4 (bromodomain-containing protein 4) has been identified as one of the main possible t…
Acute myeloid leukemia (AML) is an aggressive disease and corresponds to the lower survival rate among leukemias types. Only 40% of the patients under 60 y.o. survive more than 5 years and, in patients over 60 y.o., the chemotherapy does not provide the cure and cause death in less than a year. Thus, revealing the urgent seek for new treatments. The BRD4 (Bromodomain-containing protein 4)…
Sepsis is a Systemic Inflammatory Response Syndrome (SIRS) caused by bacteria's infection, one of the leading causes of death in ICUs. Toll-like receptors (TLR) are able to recognize Pathogen-Associated Molecular Patterns (PAMPs) initiating inflammatory responses and sepsis by activating dendritic cells (DCs). The mTOR pathway, responsible for triggering some metabolic and immunologic res…
The mTOR signaling pathway can be activated by several molecules including insulin and IGF-1, besides it can also be activated after binding of immune system receptors as T cells (TCR), B cells (BCR) and toll-like receptors (TLR). There are two mTOR complexes, mTORC1 and mTORC2, that differ in crucial components of the signalization, as the presence of raptor and rictor respectively. Rece…
Cohesin is a multisubunit protein complex initially described to provide stability to sister chromatids during cell division. Recent studies have shown the occurrence of mutations in cohesin in adult myeloid leukemic cells, however, the mechanism of how cohesin could influence on leukemia development is still unclear. Similarly, in children, a high incidence of cohesin components mutation…
Macrophages are antigen-presenting cells (APCs) and are essential first responders that trigger innate immune responses leading to appropriate adaptive immune responses. They express Toll like receptors on their surface and it is this family of receptors that recognize pathogen associated molecular patterns (PAMPs) and activate the macrophage. Activated macrophages increase expression of …
| 1 / 1 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 4 / 3 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 9 / 8 | All research grants and scholarships |
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