CV Lattes
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Sociedade Beneficente de Senhoras (SBSHSL). Hospital Sírio-Libanês (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at BIOLOGY from Universidade de São Paulo (2003), master's (2006) and doctorate (2011) at IMMUNOLOGY from Instituto de Ciências Biomédicas - USP (2006). PhD Sandwich at Université François Rabelais, Tours (2009), and at Faculté de Médecine Xavier Bichat, Paris (2009), France. Post doctorate at CSC/MRC Imperial College, London (2015), United Kingdom and at Instituto de Ciências Biomédicas da USP (2017). Currently Research Scientist at Instituto de Ensino e Pesquisa - Hospital Sírio-Libanês.Has experience in Immunology, focusing on myeloid cells modulation, mTOR pathway, kidney diseases, transplantation, sepsis and cancer. (Source: Lattes Curriculum)
Acute myeloid leukemia (AML) is a complex hematological cancer that mainly affects elderly patients (over 60 years old) and these patients are the ones that have worst response to current treatments. Thus, there is a great need for new therapeutic alternatives for this cancer. In the last decade, the BRD4 (bromodomain-containing protein 4) has been identified as one of the main possible t…
Acute myeloid leukemia (AML) is an aggressive disease and corresponds to the lower survival rate among leukemias types. Only 40% of the patients under 60 y.o. survive more than 5 years and, in patients over 60 y.o., the chemotherapy does not provide the cure and cause death in less than a year. Thus, revealing the urgent seek for new treatments. The BRD4 (Bromodomain-containing protein 4)…
Sepsis is a Systemic Inflammatory Response Syndrome (SIRS) caused by bacteria's infection, one of the leading causes of death in ICUs. Toll-like receptors (TLR) are able to recognize Pathogen-Associated Molecular Patterns (PAMPs) initiating inflammatory responses and sepsis by activating dendritic cells (DCs). The mTOR pathway, responsible for triggering some metabolic and immunologic res…
The mTOR signaling pathway can be activated by several molecules including insulin and IGF-1, besides it can also be activated after binding of immune system receptors as T cells (TCR), B cells (BCR) and toll-like receptors (TLR). There are two mTOR complexes, mTORC1 and mTORC2, that differ in crucial components of the signalization, as the presence of raptor and rictor respectively. Rece…
Cohesin is a multisubunit protein complex initially described to provide stability to sister chromatids during cell division. Recent studies have shown the occurrence of mutations in cohesin in adult myeloid leukemic cells, however, the mechanism of how cohesin could influence on leukemia development is still unclear. Similarly, in children, a high incidence of cohesin components mutation…
Macrophages are antigen-presenting cells (APCs) and are essential first responders that trigger innate immune responses leading to appropriate adaptive immune responses. They express Toll like receptors on their surface and it is this family of receptors that recognize pathogen associated molecular patterns (PAMPs) and activate the macrophage. Activated macrophages increase expression of …
| 1 / 1 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 3 / 2 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 8 / 7 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 4 |
| Citations | 41 |
| Cit./Article | 10.2 |
| Data from Web of Science | |
PASCHOAL, VIVIAN A.; AMANO, MARIANE T.; BELCHIOR, THIAGO; MAGDALON, JULIANA; CHIMIN, PATRICIA; ANDRADE, MAYNARA L.; ORTIZ-SILVA, MILENE; CASTRO, ERIQUE; YAMASHITA, ALEX S.; ROSA NETO, JOSE CESAR; et al. mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function. Immunobiology, v. 222, n. 2, p. 261-271, FEB 2017. Web of Science Citations: 18. (12/02270-2, 09/15354-7, 15/19530-5, 11/10783-7)
PASCHOAL, VIVIAN A.; BELCHIOR, THIAGO; AMANO, MARIANE T.; BURGOS-SILVA, MARINA; PEIXOTO, ALBERT S.; MAGDALON, JULIANA; VIEIRA, THAYNA S.; ANDRADE, MAYNARA L.; MORENO, MAYARA F.; CHIMIN, PATRICIA; et al. Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet-Induced Obesity. MOLECULAR NUTRITION & FOOD RESEARCH, v. 62, n. 17, SEP 2018. Web of Science Citations: 2. (12/02270-2, 09/15354-7, 15/19530-5, 11/10783-7)
AMANO, MARIANE T.; CASTOLDI, ANGELA; ANDRADE-OLIVEIRA, VINICIUS; LATANCIA, MARCELA T.; TERRA, FERNANDA F.; CORREA-COSTA, MATHEUS; BREDA, CRISTIANE N. S.; FELIZARDO, RAPHAEL J. F.; PEREIRA, WELBERT O.; DA SILVA, MARINA B.; et al. The lack of PI3K gamma favors M1 macrophage polarization and does not prevent kidney diseases progression. International Immunopharmacology, v. 64, p. 151-161, NOV 2018. Web of Science Citations: 4. (12/10435-1, 12/02270-2, 13/09563-8)
CASTOLDI, ANGELA; ANDRADE-OLIVEIRA, VINICIUS; AGUIAR, CRISTHIANE FAVERO; AMANO, MARIANE TAMI; LEE, JENNIFER; MIYAGI, MARCELLI TERUMI; LATANCIA, MARCELA TEATIN; BRAGA, TARCIO TEODORO; DA SILVA, MARINA BURGOS; IGNACIO, ALINE; et al. Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88. CELL REPORTS, v. 19, n. 11, p. 2272-2288, JUN 13 2017. Web of Science Citations: 8. (12/02270-2, 11/15682-4, 15/18121-4)
FELIZARDO, RAPHAEL J. F.; DE ALMEIDA, DANILO C.; PEREIRA, RAFAEL L.; WATANABE, INGRID K. M.; DOIMO, NAYARA T. S.; RIBEIRO, WILLIAN R.; CENEDEZE, MARCOS A.; HIYANE, MEIRE I.; AMANO, MARIANE T.; BRAGA, TARCIO T.; et al. Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms. FASEB JOURNAL, v. 33, n. 11, p. 11894-11908, NOV 2019. Web of Science Citations: 0. (14/13135-4, 12/02270-2, 12/15205-4, 12/50410-8, 17/05264-7)
SAITO MIYAGI, MARIANA YASUE; LATANCIA, MARCELA TEATIN; TESTAGROSSA, LEONARDO ABREU; DE ANDRADE-OLIVEIRA, VINICIUS; PEREIRA, WELBERT OLIVEIRA; HIYANE, MEIRE IOSHIE; ENJIU, LUCAS MACERATESI; PISCIOTTANO, MARCUS; LEITE SEELAENDER, MARILIA CERQUEIRA; SARAIVA CAMARA, NIELS OLSEN; et al. Physical exercise contributes to cisplatin-induced nephrotoxicity protection with decreased CD4+T cells activation. Molecular Immunology, v. 101, p. 507-513, SEP 2018. Web of Science Citations: 0. (12/50079-0, 11/10349-5, 12/10435-1, 12/02270-2)
ANDRADE-OLIVEIRA, VINICIUS; AMANO, MARIANE T.; CORREA-COSTA, MATHEUS; CASTOLDI, ANGELA; FELIZARDO, RAPHAEL J. F.; DE ALMEIDA, DANILO C.; BASSI, ENIO J.; MORAES-VIEIRA, PEDRO M.; HIYANE, MEIRE I.; RODAS, ANDREA C. D.; et al. Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v. 26, n. 8, p. 1877-1888, AUG 2015. Web of Science Citations: 86. (11/01016-2, 12/02270-2)
CUARTERO, SERGI; WEISS, FELIX D.; DHARMALINGAM, GOPURAJA; GUO, YA; ING-SIMMONS, ELIZABETH; MASELLA, SILVIA; ROBLES-REBOLLO, IRENE; XIAO, XIAOLIN; WANG, YI-FANG; BAROZZI, IROS; et al. Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation. NATURE IMMUNOLOGY, v. 19, n. 9, p. 932+, SEP 2018. Web of Science Citations: 21. (14/20861-3)
PEREIRA, RAFAEL LUIZ; FERREIRA FELIZARDO, RAPHAEL JOSE; CENEDEZE, MARCOS ANTOINO; HIYANE, MEIRE IOSHIE; BASSI, ENIO JOSE; AMANO, MARIANE TAMI; TAEMI ORIGASSA, CLARICE SYLVIA; SILVA, REINALDO CORREIA; AGUIAR, CRISTHIANE FAVERO; CARNEIRO, SYLVIA MENDES; et al. Balance between the two kinin receptors in the progression of experimental focal and segmental glomerulosclerosis in mice. Disease Models & Mechanisms, v. 7, n. 6, p. 701-710, JUN 2014. Web of Science Citations: 6. (07/07139-3, 12/02270-2, 12/05605-5)
DE AGUIAR, CRISTHIANE FAVERO; CASTOLDI, ANGELA; AMANO, MARIANE T.; IGNACIO, ALINE; TERRA, FERNANDA FERNANDES; CRUZ, MARIO; FELIZARDO, RAPHAEL J. F.; BRAGA, TARCIO TEODORO; DAVANZO, GUSTAVO GASTAO; GAMBARINI, VICTOR; et al. Fecal IgA Levels and Gut Microbiota Composition Are Regulated by Invariant Natural Killer T Cells. INFLAMMATORY BOWEL DISEASES, v. 26, n. 5, p. 697-708, MAY 2020. Web of Science Citations: 0. (12/16794-3, 12/02270-2, 17/12848-5)
(References retrieved automatically from State of São Paulo Research Institutions)
AMANO, MARIANE TAMI. O papel da heme oxigenase-1 na modulação de células dendríticas levando à proteção da lesão por isquemia e reperfusão.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (07/52634-2)