Maria Marluce dos Santos Vilela

• Abstract

  The present Research Project is formulated in two parts, Part I and Part II, associated with two cohorts of patients with primary immunedeficiencies (PIDs): autoimmune lymphoproliferative syndrome (ALPS) with undefined genetic etiology (ALPS-U) and agammaglobulinemia linked to X (XLA), respectively. Although different, such pathologies present some clinical manifestations in common charac…

  Identification of critical molecular targets associated with the etiology and pathophysiology of Primary Immunodeficiencies with emphasis on clinical manifestations of inflammation, immunodysregulation and autoimmunity, AP.R

• Abstract

  Apoptosis or programmed cell death is the mechanism that controls the number and removal of senescent, damaged or unnecessary cells, without causing inflammation. The process is very important in regulating the immune response. The first human disease with etiology attributed to primary defect in apoptosis was Autoimmune Lymphoproliferative Syndrome (ALPS), mainly caused by heterozygous m…

  Functional, molecular and histopathological approach of autoimmunity and lymphoproliferative syndrome as a manifestation of primary immunodeficiency, AP.R

• Abstract

  The objective of this study is to characterize in HIV-infected children and adolescents the response of dendritic cells (DC) and lymphocytes to inactivated HIV particles. The number and function of lymphocytes (NKT, CD4+, CD8+, Treg and Th17) and plasmacytoid and myeloid DC will be evaluated by flow cytometry. The thymic function will be assessed by the number of TREC copies in peripheral…

  HIV chronic infection in children and adolescents: innate and adaptive responses to inactivated HIV particles, AP.R

(Only some records are available in English at this moment)

• Abstract

  The aim of this study is to characterize in HIV-infected children and adolescents the response in cocultures of monocyte derived dendritic cells (MDDC) and lymphocytes to inactivated HIV particles. The dendritic cells will be evaluated by flow cytometry for expression of CD80, CD83, CD86, CD40 and HLA-DR and by PCR-array followed by Real Time PCR for cytokines mRNA expression of IFN-gama,…

  Cytokine gene expression from cocultures of lymphocytes and dendritic cells derived from monocytes of HIV-infected children and adolescents, BP.MS

• Abstract

  Crohn's disease (CD) is a chronic inflammatory disease that may affect any part of the gastrointestinal tract. During the acute phase, the digestive symptoms can lead to malnutrition, which often complicate the disease. However, in the disease remission phase some patients show overweight or obesity; adipose tissue produces pro-inflammatory cytokines, that can make disease problems worse…

  Crohn's disease: effect of nutrition supplements on Disease Activity Index (CDAI) and nutritional state of the patients in therapy with anti-TNF-alpha and Azathioprine., BP.MS