CV Lattes
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ORCID
Fundação Arnaldo Vieira de Carvalho. Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Has experience in Genetics, focusing on Human and Medical Genetics, acting on the following subjects: phic31, mucopolissacaridosis I, terapia gênica, vetores não-virais and plasmídeo. (Source: Lattes Curriculum)
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Injuries and diseases of the musculoskeletal system are extremely common and account for over 6 million visits to emergency departments each year. After injury, muscle tissue needs to be repaired and allowed to regenerate. During this process, the formation of fibrous tissue makes adequate muscle contraction extremely difficult and can lead to muscle contractures and chronic pain. Gene (G…
Injuries and diseases of the musculoskeletal system are extremely common and account for over 6 million visits to emergency departments each year. After injury, muscle tissue needs to be repaired and allowed to regenerate. During this process, the formation of fibrous tissue makes adequate muscle contraction extremely difficult, and can lead to muscle contractures and chronic pain. Gene (…
Muscle injuries can be caused by lacerations, strains or bruises, the latter two being responsible for more than 90% of all traumas caused in sports. In the case of more extensive injuries, in which volumetric muscle loss (LMCV) occurs, the physiological repair mechanism is overloaded, favoring dysfunctional tissue repair, with the formation of exacerbated fibrotic tissue, mainly by the r…
Being the most abundant tissue in the human body, skeletal muscle is subject to several conditions that are relatively common in the medical field, such as lacerations and bruises, resulting from trauma, ischemia, resulting from vascular insufficiency, and neurological dysfunction, which can be secondary to the trauma itself or associated diseases. The various disorders caused by these me…
Lesions and diseases of the musculoskeletal system represent more than 6 million consultations in medical emergencies in US hospitals. The damage and repair process is similar in most cases, but the functional recovery of a muscle injury varies according to the type of the trauma and the most serious injuries can progress with the formation of fibrous tissue interfering with adequate musc…
(Only some records are available in English at this moment)
In muscle injuries with big volume loss the flap-free is used as a therapeutic alternative. However, this procedure has several obstacles including the inevitable commitment of the donor source. Spheroids have emerged as a promising alternative for the production of 3D cultures, as they mimic the environment in vivo and can be used to create grafts capable of regenerated tissues and injur…
Cells have their own mechanisms to maintain the homeostasis. Autophagy is based on self-destruction and selective elimination of dysfunctional intracellular components, in which the cell relocates unneeded nutrients to more essential processes. Mitophagy is the sequestration of the mitochondria by the autophagosome followed by its degradation in the lysosomes. Both autophagy and mitophagy…
Fibrosis is characterized by an excessive accumulation of extracellular matrix components and is one of the main sequelae acquired after muscle injury. It is most prevalent in severe injuries in which healing occurs slowly and prevents proper muscle contraction - which can lead to muscle contractures and chronic pain. Besides being an important aggravating factor of muscular dystrophies, …
(Only some records are available in English at this moment)
Fibrosis is a major acquired sequel after muscle. The fibrotic process prevents proper muscle contraction and can lead to muscle contractures and chronic pain. In more severe injuries, in which healing occurs slowly, fibrosis prevents the proper muscle contraction and can lead to chronic pain and muscle contractures. In addition to functional loss, scar tissue tends to suffer further inju…
| 2 / 2 | Ongoing research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 6 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 13 / 12 | All research grants and scholarships |
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