CV Lattes
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Fundação Arnaldo Vieira de Carvalho. Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Has experience in Genetics, focusing on Human and Medical Genetics, acting on the following subjects: phic31, mucopolissacaridosis I, terapia gênica, vetores não-virais and plasmídeo. (Source: Lattes Curriculum)
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Injuries and diseases of the musculoskeletal system are extremely common and account for over 6 million visits to emergency departments each year. After injury, muscle tissue needs to be repaired and allowed to regenerate. During this process, the formation of fibrous tissue makes adequate muscle contraction extremely difficult and can lead to muscle contractures and chronic pain. Gene (G…
Injuries and diseases of the musculoskeletal system are extremely common and account for over 6 million visits to emergency departments each year. After injury, muscle tissue needs to be repaired and allowed to regenerate. During this process, the formation of fibrous tissue makes adequate muscle contraction extremely difficult, and can lead to muscle contractures and chronic pain. Gene (…
The regenerative process of the affected muscle by a traumatic injury is still a big challenge in the medical field, mainly when it has a big muscle loss exceeding the tissue´s capacity of regeneration. The area of regenerative medicine uses tools that include the use of stem cells and biomaterials to reconstruct the injured tissue or assist in tissue repair, which open perspects for a lo…
Lesions and diseases of the musculoskeletal system represent more than 6 million consultations in medical emergencies in US hospitals. The damage and repair process is similar in most cases, but the functional recovery of a muscle injury varies according to the type of the trauma and the most serious injuries can progress with the formation of fibrous tissue interfering with adequate musc…
In muscle injuries with big volume loss the flap-free is used as a therapeutic alternative. However, this procedure has several obstacles including the inevitable commitment of the donor source. Spheroids have emerged as a promising alternative for the production of 3D cultures, as they mimic the environment in vivo and can be used to create grafts capable of regenerated tissues and injur…
Cells have their own mechanisms to maintain the homeostasis. Autophagy is based on self-destruction and selective elimination of dysfunctional intracellular components, in which the cell relocates unneeded nutrients to more essential processes. Mitophagy is the sequestration of the mitochondria by the autophagosome followed by its degradation in the lysosomes. Both autophagy and mitophagy…
Fibrosis is characterized by an excessive accumulation of extracellular matrix components and is one of the main sequelae acquired after muscle injury. It is most prevalent in severe injuries in which healing occurs slowly and prevents proper muscle contraction - which can lead to muscle contractures and chronic pain. Besides being an important aggravating factor of muscular dystrophies, …
(Only some records are available in English at this moment)
Fibrosis is a major acquired sequel after muscle. The fibrotic process prevents proper muscle contraction and can lead to muscle contractures and chronic pain. In more severe injuries, in which healing occurs slowly, fibrosis prevents the proper muscle contraction and can lead to chronic pain and muscle contractures. In addition to functional loss, scar tissue tends to suffer further inju…
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 6 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 11 / 10 | All research grants and scholarships |
| Associated processes | |
MATSUMOTO MARTIN, PRISCILA KEIKO; STILHANO, ROBERTA SESSA; SAMOTO, VIVIAN YOCHIKO; TAKIYA, CHRISTINA MAEDA; PERES, GIOVANI BRAVIN; CORREA DA SILVA MICHELACCI, YARA MARIA; DA SILVA, FLAVIA HELENA; PEREIRA, VANESSA GONCALVES; D'ALMEIDA, VANIA; NAVARRO MARQUES, FABIO LUIZ; et al. Mesenchymal Stem Cells Do Not Prevent Antibody Responses against Human alpha-L-Iduronidase when Used to Treat Mucopolysaccharidosis Type I. PLoS One, v. 9, n. 3, MAR 18 2014. (08/56529-1, 09/52235-6, 08/56530-0)
STILHANO, ROBERTA SESSA; SAMOTO, VIVIAN YOCHIKO; SILVA, LEONARDO MARTINS; PEREIRA, GUSTAVO JOSE; ERUSTES, ADOLFO GARCIA; SMAILI, SORAYA SOUBHI; HAN, SANG WON. Reduction in skeletal muscle fibrosis of spontaneously hypertensive rats after laceration by microRNA targeting angiotensin II receptor. PLoS One, v. 12, n. 10, OCT 23 2017. (12/00753-6, 15/20206-8)
MADRIGAL, JUSTIN L.; STILHANO, ROBERTA S.; SILTANEN, CHRISTIAN; TANAKA, KIMBERLY; REZVANI, SABAH N.; MORGAN, RYAN P.; REVZIN, ALEXANDER; HAN, SANG W.; SILVA, EDUARDO A.. Microfluidic generation of alginate microgels for the controlled delivery of lentivectors. JOURNAL OF MATERIALS CHEMISTRY B, v. 4, n. 43, p. 6989-6999, NOV 21 2016. (12/00753-6, 15/20206-8)
RODRIGUES LEMES, ROBERTHA MARIANA; COSTA, ANGELICA JARDIM; BARTOLOMEO, CYNTHIA SILVA; BASSANI, TAYSA BERVIAN; NISHINO, MICHELLE SAYURI; DA SILVA PEREIRA, GUSTAVO JOSE; SMAILI, SORAYA SOUBHI; DE BARROS MACIEL, RUI MONTEIRO; BRACONI, CARLA TORRES; DA CRUZ, EDGAR FERREIRA; et al. 17 beta-estradiol reduces SARS-CoV-2 infection in vitro. PHYSIOLOGICAL REPORTS, v. 9, n. 2, JAN 2021. (16/20796-2, 06/60402-1, 18/06088-0, 20/06153-7, 19/10922-9, 20/04709-8)