Raquel Alves dos Santos

• Abstract

  Natural products continue to be the largest source for obtaining molecules with biological potential for the development of new drugs. Among these molecules are those belonging to the stilbene group. Being resveratrol the stilbene with widely studied biological activity and great pharmacological potential for cancer therapy, its low bioavailability has limited the progress of its use in m…

  Effects of cis-trimethoxystilbene treatment after TP53 silencing by siRNA in the tumoral cell lines MCF-7 and MDA-MB-231: a cellular and molecular approach, AP.R
• 6th Latin American Conference on Health Promotion and Education, 3rd Brazilian Interdisciplinary Congress on Health Promotion and 3rd Seminar on Health Promotion in the Paulista Interior, AO.R

• Abstract

  Genomic stability maintenance pathways represent important biological targets for developing new antineoplastic strategies. The mechanisms involved in DNA damage response (DDR) include cell cycle regulation, DNA repair and apoptosis cell death. The stilbene resveratrol is a naturally occurring compound that exerts its antitumoral activity by regulating cell proliferation and death mechani…

  Assessment of DNA damage response pathways modulated by structuraly-modified stilbenes, AP.R

(Only some records are available in English at this moment)

• Abstract

  Natural products and their metabolites are of great importance in the development of new drugs. Trichoconine VI and VIII peptaibols (TK-VI and TK-VIII, respectively) are substances isolated from endolithic fungi of the genus Hypocrea sp., and, although antibacterial, antifungal, antiviral, antimalarial, and antiproliferative activity in tumoral cells, information on the biological activit…

  Evaluation of the antiproliferative potential of trichokonin VI and VIII peptaibols in MCF-7 and MDA-MB-231 breast Cancer cell lines, BP.IC

• Abstract

  Among the challenges of global public health are sexually transmitted infections as a triggering factor of several pathologies of a genotoxic nature. The Human Papilloma Virus (HPV) is currently one of the main etiological agents of diseases associated with the female genital tract, with the possibility of developing lesions that can be malignant. With the advancement of research on the s…

  Study of micronuclei frequency and its correlation (or not) with HPV in the oral cavity in a young population, BP.IC

• Abstract

  Cervical cancer (CCU) is considered one of the leading causes of death in Brazil, being the third leading cause of death and the seventh most common worldwide. The main risk factors are smoking, early initiation of sexual life, and use of oral contraceptives, among others, which include HPV virus infection. In the search for new therapeutic alternatives for this disease, there are natural…

  Analysis of the cellular effects of the standardized red propolis extract on HeLa and SiHa Cervix Cancer cell lines, BP.IC

(Only some records are available in English at this moment)