Graduate at Ciências Biológicas from Universidade de São Paulo (1972), master's at Genética e Melhoramento de Plantas ESALQ from Universidade de São Paulo (1979) and Ph.D. at Genética FMRP from Universidade de São Paulo (1984). Has experience in Genetics, focusing on Molecular Genetics of Microorganisms, acting on the following subjects: gene expression, response to ambient stress, and mechanisms of antifungal resistance. (Source: Lattes Curriculum)
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Dermatophyte Trichophyton rubrum is the pathogenic fungus with the highest incidence in clinical cases of superficial mycoses in human skin and nails. Although these infections are widespread, the mechanisms associated with successful pathogen-host interaction and drug resistance factors remain misunderstood. Considerable research efforts are being undertaken, aiming at the control of inf…
Dermatophytes are filamentous fungi that use keratin as a nutrient source during infection of skin, nail and hair. Dermatophyte adherence and secretion of enzymes are key factors in the colonization of the host tissues, which can be regulated in response to phosphate levels, different carbon and nitrogen sources, and ambient pH. Dermatophytoses constitute one of the most common fungal inf…
We are requesting a fluorescence microscope with structured illumination for three-dimensional analysis of the images captured (images of sections from organs or tissues). The equipment is state-of-the-art and will provide us with the image analysis capability and technical sophistication generated through hybridization and immunofixation protocols, thereby promoting the expansion of know…
(Only some records are available in English at this moment)
Trichophyton rubrum is currently the main causative of dermatophytosis globally. The knowledge of molecular pathways that coordinate their biology is fundamental for developing new models of study about pathogenic fungi. Some crucial characteristics, such as the differential expression of stress response genes, provide adaptive value for the fungus allowing its maintenance in the face of …
Computational models that aim to identify potential antifungal targets have been successfully used for fungi such as Aspergillus fumigatus and yeasts and show the possible use of large-scale sequencing for this purpose. The genome of several pathogenic fungi, including dermatophytes, is known and strongly contributes to comparative analyses and the identification of gene classes enriched …
Signal transduction pathways are of primary importance in the context of the parasitic interaction that some dermatophyte fungi develop with humans. Such infections are difficult to treat and represent a clinical issue of great relevance nowadays, especially in vulnerable or aging populations. By responding to specific stimuli from the environment, transduction pathways can modulate cellu…
Trichophyton rubrum is one of the most prevalent species causing dermatophytosis worldwide. Its anthropophilic character, along with its sequenced genome, makes it a very useful model for studying the biology of pathogenic fungi - and, in association, also for the recognition of potential metabolic pathways as drug targets. In the context applied to antifungal therapies, biomolecules that…
Fungi respond to extracellular stimuli by activating signal transduction pathways responsible for physiological mechanisms that allow adaptation to stress, the development of cell defense, and tolerance. The antifungal drugs induce cellular stress responses needed to overcome their toxic effects, possibly allowing the survival of the fungus. Knowledge of the molecular mechanism of the ada…
Cytotoxic agents are commonly used to control infections, but their mechanism of action is often poorly understood. Dermatophytes of the genus Trichophyton infect healthy individuals and dermatophytosis are among the few fungal diseases that are transmitted directly from person to person. T. rubrum is a cosmopolitan fungus and the most common cause of nail and skin infections. It is, in m…
(Only some records are available in English at this moment)
Dermatophytes are a phylogenetically related group of filamentous fungi able to invade and colonize keratinized tissues in human and animals. These species can be classified as geophilic, zoophilic and anthropophilic, based on their preferable niches, such as soil, animals and humans, respectively. The genome of seven dermatophytes species was recently sequenced and comparative analysis h…
| 1 / 1 | Ongoing research grants |
| 20 / 9 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 21 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 46 / 21 | All research grants and scholarships |
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CV Lattes
ORCID