Heraldo Possolo de Souza
CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Medicina from Faculdade de Medicina da Universidade de São Paulo (1986) and ph.d. at Medicina from Faculdade de Medicina da Universidade de São Paulo (1998). Has experience in Medicine, acting on the following subjects: superoxide, nad p h oxidase, endothelium, vascular and injury. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| FAPESP selects 30 projects in call for research proposals to combat novel coronavirus |
- Patients with Severe Acute Respiratory Syndrome due to COVID-19 in an emergency department, AP.R
Abstract
The current Covid-19 pandemic has affected more than 920,000 people and killed more than 46,000 worldwide. Most affected patients have a mild condition, but a small percentage, from the percentage point of view, but large in absolute numbers, may have a severe acute respiratory syndrome (SARS), with fever, cough, pulmonary infiltrates and hypoxemia, and may progress for respiratory fail...
- Diagnostic and prognostic markers in patients admitted to an emergency department, AP.TEM
Abstract
The emergency physician's ability to quickly diagnose and make a prognosis about the evolution of a seriously ill patient can not only save lives but also help to reduce the burden on medical services. Unfortunately, not all diseases have specific markers that can help physicians in this decision (as is the case of troponin in patients with acute myocardial infarction). So our main goal...
- OCRC - Obesity and Comorbidities Research Center, AP.CEPID
Abstract
Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected...
- Interactions between inflammation and obesity: mechanisms by which the inflammatory process affects adipogenesis and obesity complications, AP.R
Abstract
There is evidence that obesity complications such as type 2 diabetes and dyslipidemia can be attributed, at least partially, to the inflammatory response that occurs within adipose tissue.However, it is still unclear whether inflammation alone may play a role in the genesis of obesity. We also do not know the influence of an acute inflammatory event, such as that observed in sepsis, on ...
- The role of transcription coactivators PGC-1 in the inflammatory process, AP.R
Abstract
The family of transcriptional coactivators PGC-1 comprises three members (PGC-1±, PGC-1² and PRC), with extensive homology, but with different functions and expression patterns. Their main function is related to mitochondrial biogenesis and function. Moreover, they play key roles in controlling energy homeostasis, including hepatic gluconeogenesis, lipoprotein metabolism, thermogenesis,...
- Nuclear receptors and transcription coactivators in inflammatory diseases, AP.R
(Only some records are available in English at this moment)
- Evaluation of elderly people at an emergency service, BP.PD
Abstract
There is a huge shortage of data on emergency care patient care throughout Brazil. This lack of data is even more evident when we focus attention on the elderly population.In this project, we aim to identify the population of patients seeking an Emergency Service, particularly those over 60, their clinical and laboratory differences from younger populations, and to assess whether severi...
- Subcutaneous adipose tissue formation mechanisms in a lymphedema experimental model, BP.IC
Abstract
The increase in the adipose subcutaneous tissue is related to very prevalent diseases such as obesity and the lymphedema secondary to lymphatic obstruction (most commonly associated to cancer treatment). Recently, it was developed an experimental model in which the lymphatic vessels blockage in the proximal portion of mice tails leads to the development of subcutaneous deposits of fat, ...
- PGC-1 coativator in sepsis model, BP.IC
- Expression of PGC-1 transcription factor coactivator during immune response to bacteria, BP.IC
Abstract
PGC-1 alfa and beta are transcription coactivators, a new class of proteins that, although they do not bind directly to DNA, may control the genetic response. PGC-1 can bind to several transcription factors, leading to increased expression of genes involved in mitochondrial biogenesis and respiratory function. This response can cause enhanced enzymatic fatty acids oxidation, Krebs cycl...
| 3 / 3 | Ongoing research grants |
| 6 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 5 / 3 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 16 / 11 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 8 |
| Citations | 111 |
| Cit./Article | 13.9 |
| Data from Web of Science | |
FERNANDES‚ T.R.; PONTIERI‚ V.; MORETTI‚ A.I.; TEIXEIRA‚ D.O.; ABATEPAULO‚ F.; SORIANO‚ F.G.; NEGRI‚ E.M.; VELASCO‚ I.T.; SOUZA‚ H.P.. Hypertonic saline solution increases the expression of heat shock protein 70 and improves lung inflammation early after reperfusion in a rodent model of controlled hemorrhage. Shock, v. 27, n. 2, p. 172-178, 2007.
SOUZA, HERALDO P.; FREDIANI, DENISE; COBRA, ANA L.; MORETTI, ANA I.; JURADO, MARCIA C.; FERNANDES, THADEU R.; CARDOUNEL, ARTURO J.; ZWEIER, JAY L.; TOSTES, RITA C.. Angiotensin II modulates CD40 expression in vascular smooth muscle cells. Clinical Science, v. 116, n. 5-6, p. 423-431, MAR 2009. Web of Science Citations: 13.
GODOY, LUIZ C.; MORETTI, ANA I.; JURADO, MARCIA C.; OXER, DANIELLA; JANISZEWSKI, MARIANO; CKLESS, KARINA; VELASCO, IRINEU T.; LAURINDO, FRANCISCO R. M.; SOUZA, HERALDO P.. LOSS OF CD40 ENDOGENOUS S-NITROSYLATION DURING INFLAMMATORY RESPONSE IN ENDOTOXEMIC MICE AND PATIENTS WITH SEPSIS. Shock, v. 33, n. 6, p. 626-633, JUN 2010. Web of Science Citations: 15.
ASSIS, LIVIA; MORETTI, ANA I. S.; ABRAHAO, THALITA B.; CURY, VIVIAN; SOUZA, HERALDO P.; HAMBLIN, MICHAEL R.; PARIZOTTO, NIVALDO A.. Low-level laser therapy (808 nm) reduces inflammatory response and oxidative stress in rat tibialis anterior muscle after cryolesion. Lasers in Surgery and Medicine, v. 44, n. 9, p. 726-735, NOV 2012. Web of Science Citations: 64. (09/01990-9)
FERREIRA, DARKIANE FERNANDES; FIAMONCINI, JARLEI; PRIST, IRYNA HIRATA; ARIGA, SUELY KUBO; DE SOUZA, HERALDO POSSOLO; DE LIMA, THAIS MARTINS. Novel role of TLR4 in NAFLD development: Modulation of metabolic enzymes expression. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1851, n. 10, p. 1353-1359, OCT 2015. Web of Science Citations: 9. (09/01990-9, 09/07946-1)
CESAR MACHADO, MARCEL CERQUEIRA; SOUZA, HERALDO POSSOLO. The increased severity of acute pancreatitis in the elderly is mainly related to intestinal barrier dysfunction. Hepatobiliary & Pancreatic Diseases International, v. 17, n. 6, p. 575-577, DEC 2018. Web of Science Citations: 0. (17/05232-8)
CARDINOT, THEMIS M.; LIMA, THAIS M.; MORETTI, ANA I. S.; KOIKE, MARCIA K.; NUNES, VALERIA S.; CAZITA, PATRICIA M.; KRIEGER, MARTA H.; BRUM, PATRICIA C.; SOUZA, HERALDO P.. Preventive and therapeutic moderate aerobic exercise programs convert atherosclerotic plaques into a more stable phenotype. Life Sciences, v. 153, p. 163-170, MAY 15 2016. Web of Science Citations: 4. (09/01990-9)
BARROSO, WERMERSON ASSUNCAO; VICTORINO, VANESSA JACOB; JEREMIAS, ISABELA CASAGRANDE; PETRONI, RICARDO COSTA; KUBO ARIGA, SUELY KUNIMI; SALLES, THIAGO A.; BARBEIRO, DENISE FREDIANI; DE LIMA, THAIS MARTINS; DE SOUZA, HERALDO POSSOLO. High-fat diet inhibits PGC-1 alpha suppressive effect on NF kappa B signaling in hepatocytes. EUROPEAN JOURNAL OF NUTRITION, v. 57, n. 5, p. 1891-1900, AUG 2018. Web of Science Citations: 6. (12/07957-6)
ARRUDA, G.; ARIGA, S.; DE LIMA, T. M.; SOUZA, H. P.; ANDRADE, M.. A MODIFIED MOUSE-TAIL LYMPHEDEMA MODEL. LYMPHOLOGY, v. 53, n. 1, p. 29-37, MAR 2020. Web of Science Citations: 0. (17/05232-8)
(References retrieved automatically from State of São Paulo Research Institutions)
CARDINOT, Themis Moura. Efeito do treinamento físico aeróbico na prevenção e terapêutica da doença aterosclerótica em modelo experimental de aterosclerose. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (05/55108-4)