Abstract
We will implement statistical tests designed to identify deviation from backgroundancestry within the MHC region (Grinde et al. 2019). Local ancestry will be estimated usingRFMIX (Maples et al. 2013) or other methods that may be developed during the fundingperiod. We will use simulations to evaluate the robustness of local ancestry estimation in theMHC. To do so, we will use forward simul…