Alessandra Gambero

• Abstract

  The elderly population with or without associated comorbidities, such as diabetes and cardiovascular disease is the most vulnerable group to COVID-19 mortality. Cell senescence is the process of cell aging that increases during the progression of chronic diseases (such as diabetes) and with aging, resulting in irreversible arrest of the cell cycle controlled by the p53 / p21 and p16 / Rb …

  Senotherapeutic potential of drugs and polyphenols combinations, AP.R

• Abstract

  Structured lipids are triacylglycerols restructured in relation to their composition or distribution of fatty acids in the glycerol backbone in order to modify physicochemical or nutritional properties. Structured lipids containing behenic acid, a long chain saturated fatty acid, are partially absorbed and can act as inhibitors of pancreatic lipase in the intestine, reducing lipid absorpt…

  "Structured lipid containing behenic acid in obesity and inflammation"., AP.R

• Abstract

  Weight loss dieting and bariatric surgery remains the choice for the obese individuals that needs weight loss. However, the most part of patients that lose weight present weight regain, phenomenon named weight cycling. Not all obesity alterations were reverted during weight loss and after a weight regain, some inflammatory markers were worsened when compared with mice that were all time o…

  Weight cycling: mast cell role, vascular and tissue remodeling and inflammation resolution evaluation, AP.R

(Only some records are available in English at this moment)

• Abstract

  The aging of the population is at an accelerated rate and there is an increase in diseases such as idiopathic pulmonary fibrosis, which is a disease that affects more the elderly population. Idiopathic pulmonary fibrosis is caused by the deposition of extracellular matrix in the interstitial space and the loss of epithelial cells from the alveoli. Since this disease manifests itself more …

  ANTIFIBROTIC POTENTIAL OF DRUGS AND POLYPHENOLS COMBINATIONS., BP.IC

• Abstract

  Biometals such as iron, zinc and chromium exhibit important metabolic effects and may alter metabolic homeostasis and/or interfere with the progression of metabolic diseases as diabetes. These biometals must be consumed in the diet, absorbed, stored and distributed appropriately to the target tissues, to perform their biological function, because failures in this process result in deficie…

  Iron chelators activity on adipose tissue and skeletal muscle in obese mice and in vitro in 3T3-L1 and C2C12 cells, BP.MS

• Abstract

  Ischemia and reperfusion develops when there is an obstruction of blood vessels with subsequent restoration of flow, and its occurs in cases of myocardial ischemia, shock, trauma, hemorrhagic injury, surgery and transplantation. During hepatic ischemia, for example, there is production of free radicals that activate Kuppfer cells (macrophages residing in the liver) resulting in proinflamm…

  Effect of systemic inflammation following ischemia / reperfusion upon the visceral adipose tissue of mice, BP.MS

(Only some records are available in English at this moment)