Graduate at Veterinary Medicine from Universidade Estadual Paulista Júlio de Mesquita Filho (1986), master's at Patologia Veterinária from Universidade Estadual Paulista Júlio de Mesquita Filho (1999) and ph.d. at Medicina Veterinária Clínica Médica Jaboticabal from Universidade Estadual Paulista Júlio de Mesquita Filho (2001). Has experience in Veterinary Medicine, focusing on Animal Clinical Pathology, acting on the following subjects: imuno-histoquímica, cadelas, neoplasia mamária, diagnóstico and cadela. (Source: Lattes Curriculum)
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The canine breast tumor (TM) is a valuable clinical model for breast cancer (CM) in women because it shares etiological, clinical, histopathological, molecular and prognostic similarities with the disease in humans. The combination of the dogs' inherently shorter life expectancy, the manifestation of spontaneous disease and the multifactorial etiology, allows for improved data collection …
Loco-regional invasion and metastasis are the major causes of morbidity and mortality in most solid tumors, including head and neck squamous cell carcinomas (HNSCC). The sustained incidence and shifting epidemiological profile of HNSCC associated with the poor and marginally improved 5-year survival rates, high recurrence and severe functional and psychological negative consequences affec…
Breast cancer (BC) is the most prevalent type of tumor among women and has a high mortality rate. This is attributed to failure to detect early disease and absence of effective markers to estimate the risk of cancer progression and to predict tumor response to chemo and radiotherapy. In dogs, being about 50% of the tumors diagnosed as malignant. In addition, BC in dogs shares many similar…
Cancer stem cells (CSCs) have been associated with metastasis and therapeutic resistance and can be generated via epithelial mesenchymal transition (EMT). Some studies suggest that the hormone melatonin acts in CSCs and may participate to the inhibition of the EMT. The objectives of this study were to evaluate the formation of mammospheres from the canine and human breast cancer cell line…
(Only some records are available in English at this moment)
Cancer is a disease that involves the disordered growth of cells, which can disseminate all over the body. The mammary tumor is among the most common in the human and canine species, and the similarities in occurrence between these two species are very important. In addition, they both present a high rate of mortality and morbidity. In this disease, there are clinical and laboratory progn…
Breast cancer is one of the most frequent neoplasms in women in Brazil and in the world. In 2020, it was estimated that 2.3 million new cases were occurring worldwide, while in Brazil, 66.280 new cases are estimated for each year of the triennium 2020-2022, with higher rates in the South and Southeast regions. Melatonin is a neurohormone synthesized by the pineal gland and its secretion r…
Galanin, originally assigned as neuropeptide, has been associated in several physiologic and pathologic processes, being its activity regulated by GALR1, GALR2 and GALR3 receptors. Specifically, GALR2 exhibits pro-tumoral property in head and neck squamous cells carcinoma (HNSCC) and is the only one among the others expressed in peripheral mononuclear cells. In rodents, HNSSC cells invasi…
(Only some records are available in English at this moment)
Malignant neoplasms of spontaneous occurrence in the canine species are considered an adequate model for the study of biological and therapeutic concepts of cancer in the human species. Breast neoplasms are the main cause of cancer in bitches, with the highest occurrence in middle-aged to elderly females, not castrated, without racial predisposition, being the main cause of cancer death, …
Breast cancer is the most frequent malignant neoplasm among women. For a good prognosis, a significant challenge is tumor recurrence, which, in many cases, results from the development of resistant cells to previous chemotherapy treatment. Mechanisms such as DNA repair and the mesenchymal epithelial transition are involved with the induction of chemoresistance. The first process is respon…
Breast cancer (BC) is the tumoral type which is more prevalent among women and it has a high mortality rate, due to failure in detecting it early and to the absence of effective markers as well. In dogs, approximately 50% of the mammary tumours are diagnosed as malignant. Thus, the canine mammary tumour (CMT) resembles a great deal with those tumours in humans, which make them excellent m…
(Only some records are available in English at this moment)
Breast cancer is the most common tumor type in women, and the leading cause of death of these patients is tumor progression and metastasis. microRNAs (miRNAs) are small non-coding mRNA molecules that play a key role in gene regulation. Recent studies have shown that miRNAs are directly involved in the initiation and progression of several tumor types, including breast cancer. Several miRN…
Breast cancer is the most common cancer in women being rated as the second most frequent type of cancer in the world. Solid tumors are recognized by a microenvironment, which is exposed to adverse conditions, such as hypoxia and acidosis that can play selective pressures that drive a natural selection, leading to creating of sub-populations of tumor cells that have selective advantage (ha…
Breast cancer is the most common and major cause of death by this disease among women worldwide. Many studies are being conducted to factors that control growth, death and cell proliferation besides angiogenesis. VEGF (vascular endothelial growth factor) is essential for the creation of new blood vessels and has been associated with tumor growth and proliferation. On the other hand, Angio…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 21 / 15 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 72 / 54 | Completed scholarships in Brazil |
| 8 / 8 | Completed scholarships abroad |
| 107 / 83 | All research grants and scholarships |
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CV Lattes
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