Debora Aparecida Pires de Campos Zuccari
CV Lattes
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Secretaria de Desenvolvimento Econômico (São Paulo - Estado). Faculdade de Medicina de São José do Rio Preto (FAMERP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate at Veterinary Medicine from Universidade Estadual Paulista Júlio de Mesquita Filho (1986), master's at Patologia Veterinária from Universidade Estadual Paulista Júlio de Mesquita Filho (1999) and ph.d. at Medicina Veterinária Clínica Médica Jaboticabal from Universidade Estadual Paulista Júlio de Mesquita Filho (2001). Has experience in Veterinary Medicine, focusing on Animal Clinical Pathology, acting on the following subjects: imuno-histoquímica, cadelas, neoplasia mamária, diagnóstico and cadela. (Source: Lattes Curriculum)
- Tumor biomarkers in liquid biopsy: study of resistance mechanisms to block DNA repair: a comparative analysis, AP.R
Abstract
Breast cancer (BC) is the most prevalent type of tumor among women and has a high mortality rate. This is attributed to failure to detect early disease and absence of effective markers to estimate the risk of cancer progression and to predict tumor response to chemo and radiotherapy. In dogs, being about 50% of the tumors diagnosed as malignant. In addition, BC in dogs shares many simil...
- Effect of melatonin in epithelial mesenchymal transition markers and invasive properties of breast cancer stem cells of canine and human cell lines, PUB.ART
Abstract
Cancer stem cells (CSCs) have been associated with metastasis and therapeutic resistance and can be generated via epithelial mesenchymal transition (EMT). Some studies suggest that the hormone melatonin acts in CSCs and may participate to the inhibition of the EMT. The objectives of this study were to evaluate the formation of mammospheres from the canine and human breast cancer cell li...
- European Cancer Congress 2015, AR.EXT
- Melatonin and miRNAs in triple negative breast cancer, AP.R
Abstract
Breast cancer is the most prevalent type of tumor among women. The stages of initiation, progression and tumor invasion are triggered by genetic changes in tumor cells, that also receive influence of inflammatory and angiogenic factors released in the tumor microenvironment. MicroRNAs (miRNAs) are small non-coding mRNA molecules that play an important role in gene regulation. Several mi...
(Only some records are available in English at this moment)
- Induction of chemoresistance in human breast cancer linage cells and subsequent treatment with specific target chemotherapeutic agents, BP.IC
Abstract
Breast cancer is the most frequent malignant neoplasm among women. For a good prognosis, a significant challenge is tumor recurrence, which, in many cases, results from the development of resistant cells to previous chemotherapy treatment. Mechanisms such as DNA repair and the mesenchymal epithelial transition are involved with the induction of chemoresistance. The first process is resp...
- Immunohistochemistry evaluation of PARP and caspase-3 as prognostic markers in prostate cancer, BP.IC
Abstract
Prostate cancer (PC) is a neoplasia with high global incidence and variable behaviour, whose progression could lead to letal complications. Due to its heterogeneous character, the therapeutic choices depend on the clinical initial presentation. For this matter, the discovery of predictive biomarkers is of significant importance, intending to improve disease prognosis and its treatment. ...
- Chemoresistance induction in line cells of the CF41 canine mammary tumour and its relation to PARP and its inhibitor, BP.IC
Abstract
Breast cancer (BC) is the tumoral type which is more prevalent among women and it has a high mortality rate, due to failure in detecting it early and to the absence of effective markers as well. In dogs, approximately 50% of the mammary tumours are diagnosed as malignant. Thus, the canine mammary tumour (CMT) resembles a great deal with those tumours in humans, which make them excellent...
(Only some records are available in English at this moment)
- MiRNA-210 as diagnostic and prognostic marker for women with breast cancer, BP.IC
Abstract
Breast cancer is the most prevalent neoplasm and mortality in women worldwide, and in 2018 it was estimated the occurrence of 57,960 new cases in Brazil. Current diagnostic methods are mainly limited to invasive procedures, and even after diagnosis, prognostic determination may not be conclusive, as patients may gain resistance to treatment, favoring tumor growth, invasion, and metastas...
- Verification of agomelatine in comparison to melatonin as a therapeutic agent in breast cancer, BP.IC
Abstract
Breast cancer is the most prevalent neoplasm in women worldwide. In 2016, it was estimated that 57,960 new cases occurred in Brazil. This cancer presents a high mortality rate and morbidity, so it is interesting to discover new therapeutic agents. Several studies have found that melatonin, the main hormone synthesized by the pineal gland, regulates the circadian cycle and plays an impor...
- Signatures of circulating microRNAs in diagnosis and prognosis of women with breast cancer, BP.MS
Abstract
Breast cancer is the most common tumor type in women, and the main cause of death in these patients is tumor progression and the development of metastases. The identification of tumor markers that can predict tumor behavior is of particular interest to scientific community. Currently, the molecular characterization of several types of tumors, including breast cancer, has traditionally b...
(Only some records are available in English at this moment)
- Effect of melatonin on the modulation of miRNAs involved in breast cancer metastasis, BE.EP.DR
Abstract
Breast cancer is the most common tumor type in women, and the leading cause of death of these patients is tumor progression and metastasis. microRNAs (miRNAs) are small non-coding mRNA molecules that play a key role in gene regulation. Recent studies have shown that miRNAs are directly involved in the initiation and progression of several tumor types, including breast cancer. Several mi...
- Radiomic analysis of breast cancer animal model after melatonin treatment, BE.EP.PD
Abstract
Breast cancer is the most common cancer in women being rated as the second most frequent type of cancer in the world. Solid tumors are recognized by a microenvironment, which is exposed to adverse conditions, such as hypoxia and acidosis that can play selective pressures that drive a natural selection, leading to creating of sub-populations of tumor cells that have selective advantage (...
- Actions of melatonin and ionizing radiation on proteins related with angiogenesis in human breast cancer cells, BE.EP.IC
Abstract
Breast cancer is the most common and major cause of death by this disease among women worldwide. Many studies are being conducted to factors that control growth, death and cell proliferation besides angiogenesis. VEGF (vascular endothelial growth factor) is essential for the creation of new blood vessels and has been associated with tumor growth and proliferation. On the other hand, Ang...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 17 / 14 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 67 / 49 | Completed scholarships in Brazil |
| 8 / 8 | Completed scholarships abroad |
| 98 / 77 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 22 |
| Citations | 235 |
| Cit./Article | 10.7 |
| Data from Web of Science | |
ZUCCARI, D. A. P. C.; CASTRO, R.; JARDIM, B. V.; MANCINI, U. M.; POLACHINI, G. M.. Immunohistochemical and molecular expression of laminin-332 gamma-2 chain in canine mammary tumors. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 63, n. 1, p. 28-35, FEB 2011. Web of Science Citations: 0.
ZUCCARI, D. A. P. C.; CASTRO, R.; GAVIOLI, A. F.; MANCINI, U. M.; FRADE, C. S.; LEONEL, C.. Immunohistochemical and molecular analysis of caveolin-1 expression in canine mammary tumors. Genetics and Molecular Research, v. 11, n. 1, p. 153-165, 2012. Web of Science Citations: 4.
ZUCCARI, DEBORA A. P. C.; CASTRO, RODRIGO; GAVIOLI, ARIELI F.; MANCINI, ULISES M.; TAJARA, ELOISA H.; FRADE, CIBELLI S.; PIVARO, LUANA R.; CARMONA-RAPHE, JULIANA; TERZIAN, ANA CAROLINA B.; RUIZ, CAMILA M.; et al. The maspin expression in canine mammary tumors: An immunohistochemical and molecular study. Pesquisa Veterinária Brasileira, v. 29, n. 2, p. 167-173, FEB 2009. Web of Science Citations: 1.
JARDIM-PERASSI, BRUNA VICTORASSO; ARBAB, ALI S.; FERREIRA, LIVIA CARVALHO; BORIN, THAIZ FERRAZ; VARMA, NADIMPALLI R. S.; ISKANDER, A. S. M.; SHANKAR, ADARSH; ALI, MESER M.; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer. PLoS One, v. 9, n. 1, JAN 9 2014. Web of Science Citations: 73. (11/01054-1, 11/01052-9, 12/05065-0)
BERNARDES‚ A.C.; ZUCCARI‚ C.; PEREIRA‚ R.S.; PAVAM‚ M.V.; RUIZ‚ C.M.. Avaliação da caspase-3 e Ki-67 como marcadores prognósticos nas neoplasias mamárias em cadelas. Brazilian Journal of Veterinary Research and Animal Science, v. 44, n. 2, p. 96-102, 2007.
MOSCHETTA, MARINA G.; LEONEL, CAMILA; MASCHIO-SIGNORINI, LARISSA B.; BORIN, THAIZ F.; GELALETI, GABRIELA B.; JARDIM-PERASSI, BRUNA V.; FERREIRA, LIVIA C.; SONEHARA, NATHALIA M.; CARVALHO, LIVIA G. S.; HELLMEN, EVA; et al. Evaluation of Angiogenesis Process after Metformin and LY294002 Treatment in Mammary Tumor. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 19, n. 5, p. 655-666, 2019. Web of Science Citations: 0. (13/19862-2)
MARTINS, GUSTAVO RODRIGUES; GELALETI, GABRIELA BOTTARO; MOSCHETTA, MARINA GOBBE; MASCHIO-SIGNORINI, LARISSA BAZELA; PIRES DE CAMPOS ZUCCARI, DEBORA AP. Proinflammatory and Anti-Inflammatory Cytokines Mediated by NF-kappa B Factor as Prognostic Markers in Mammary Tumors. Mediators of Inflammation, 2016. Web of Science Citations: 11. (12/06098-0)
GELALETI, G. B.; BORIN, T. F.; MASCHIO-SIGNORINI, L. B.; MOSCHETTA, M. G.; HELLMEN, E.; VILORIA-PETIT, A. M.; ZUCCARI, D. A. P. C.. Melatonin and IL-25 modulate apoptosis and angiogenesis mediators in metastatic (CF-41) and non-metastatic (CMT-U229) canine mammary tumour cells. VETERINARY AND COMPARATIVE ONCOLOGY, v. 15, n. 4, p. 1572-1584, DEC 2017. Web of Science Citations: 1. (12/06098-0, 12/02128-1)
BORIN, THAIZ FERRAZ; ZUCCARI, DEBORA A. P. C.; JARDIM-PERASSI, BRUNA V.; FERREIRA, LIVIA C.; ISKANDER, A. S. M.; VARMA, NADIMPALLI RAVI S.; SHANKAR, ADARSH; GUO, AUSTIN M.; SCICLI, GUILLERMO; ARBAB, ALI S.. HET0016, a Selective Inhibitor of 20-HETE Synthesis, Decreases Pro-Angiogenic Factors and Inhibits Growth of Triple Negative Breast Cancer in Mice. PLoS One, v. 9, n. 12, DEC 30 2014. Web of Science Citations: 16. (12/12114-8)
MOSCHETTA, MARINA GOBBE; MASCHIO, LARISSA BAZELA; JARDIM-PERASSI, BRUNA VICTORASSO; GELALETI, GABRIELA BOTTARO; LOPES, JULIANA RAMOS; LEONEL, CAMILA; GONCALVES, NAIANE DO NASCIMENTO; FERREIRA, LIVIA CARVALHO; MARTINS, GUSTAVO RODRIGUES; BORIN, THAIZ PERRAZ; et al. Prognostic value of vascular endothelial growth factor and hypoxia-inducible factor 1 alpha in canine malignant mammary tumors. ONCOLOGY REPORTS, v. 33, n. 5, p. 2345-2353, MAY 2015. Web of Science Citations: 4. (10/13977-4, 09/14883-6)
BORIN, THAIZ FERRAZ; ARBAB, ALI SYED; GELALETI, GABRIELA BOTTARO; FERREIRA, LIVIA CARVALHO; MOSCHETTA, MARINA GOBBE; JARDIM-PERASSI, BRUNA VICTORASSO; ISKANDER, A. S. M.; VARMA, NADIMPALLI RAVI S.; SHANKAR, ADARSH; COIMBRA, VERENA BENEDICK; et al. Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression. Journal of Pineal Research, v. 60, n. 1, p. 3-15, JAN 2016. Web of Science Citations: 51. (11/13154-0, 11/20850-3, 11/18986-4, 12/12114-8, 11/18987-0)
BOTTINO, JENIFER; GELALETI, GABRIELA BOTTARO; MASCHIO, LARISSA BAZELA; JARDIM-PERASSI, BRUNA VICTORASSO; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Immunoexpression of ROCK-1 and MMP-9 as prognostic markers in breast cancer. ACTA HISTOCHEMICA, v. 116, n. 8, p. 1367-1373, 2014. Web of Science Citations: 16. (11/13154-0)
DEBORA A.P.C. ZUCCARI; MARCILIA V. PAVAM; CAROLINA B. TERZIAN; RODRIGO S. PEREIRA; CAMILA M. RUIZ; JOANNA COELHO ANDRADE. Immunohistochemical evaluation of e-cadherin, Ki-67 and PCNA in canine mammary neoplasias: correlation of prognostic factors and clinical outcome. Pesquisa Veterinária Brasileira, v. 28, n. 4, p. 207-215, Abr. 2008.
COLOMBO, JUCIMARA; WOLF MACIEL, JOAO MARCOS; FERREIRA, LIVIA CARVALHO; DA SILVA, RENATO FERREIRA; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Effects of melatonin on HIF-1 alpha and VEGF expression and on the invasive properties of hepatocarcinoma cells. Oncology Letters, v. 12, n. 1, p. 231-237, JUL 2016. Web of Science Citations: 19. (13/06421-8)
MASCHIO-SIGNORINI, LARISSA B.; GELALETI, GABRIELA B.; MOSCHETTA, MARINA G.; BORIN, THAIZ F.; JARDIM-PERASSI, BRUNA V.; LOPES, JULIANA R.; LACERDA, JESSICA Z.; ROELA, ROSIMEIRE A.; BORDIN, NEWTON A.; CORREA, LIZANDRA A.; et al. Melatonin Regulates Angiogenic and Inflammatory Proteins in MDA-MB-231 Cell Line and in Co-culture with Cancer-associated Fibroblasts. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 16, n. 11, p. 1474-1484, 2016. Web of Science Citations: 10. (13/07546-9)
GELALETI, GABRIELA BOTTARO; BONIN, THAIZ FERRAZ; MASCHIO-SIGNORINI, LARISSA BAZELA; MOSCHETTA, MARINA GOBBE; JARDIM-PERASSI, BRUNA VICTORASSO; CALVINHO, GUILHERME BERTO; FACCHINI, MARIANA CASTILHO; VILORIA-PETIT, ALICIA M.; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines. Life Sciences, v. 183, p. 98-109, AUG 15 2017. Web of Science Citations: 6. (12/06098-0, 12/02128-1)
LEONEL, CAMILA; FERREIRA, LIVIA CARVALHO; BORIN, THAIZ FERRAZ; MOSCHETTA, MARINA GOBBE; FREITAS, GABRIELA SCAVACINI; HADDAD, MICHEL RAINERI; DE CAMARGOS PINTO ROBLES, JOAO ANTONIO; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Inhibition of Epithelial-mesenchymal Transition in Response to Treatment with Metformin and Y27632 in Breast Cancer Cell Lines. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 17, n. 8, p. 1113-1125, 2017. Web of Science Citations: 5. (12/14079-5)
ZUCCARI, D. A. P. C.; CASTRO, R.; GELALETI, G. B.; MANCINI, U. M.. Interleukin-8 expression associated with canine mammary tumors. Genetics and Molecular Research, v. 10, n. 3, p. 1522-1532, 2011. Web of Science Citations: 7.
DE CASTRO, TIALFI B.; MOTA, ANDRE L.; BORDIN-JUNIOR, NEWTON A.; NETO, DALISIO S.; ZUCCARI, DEBORA A. P. C.. Immunohistochemical Expression of Melatonin Receptor MT1 and Glucose Transporter GLUT1 in Human Breast Cancer. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 18, n. 15, p. 2110-2116, 2018. Web of Science Citations: 0. (15/02935-2)
JARDIM-PERASSI, BRUNA V.; HUANG, SUNING; DOMINGUEZ-VIQUEIRA, WILLIAM; POLESZCZUK, JAN; BUDZEVICH, MIKALAI M.; ABDALAH, MAHMOUD A.; PILLAI, SMITHA R.; RUIZ, EPIFANIO; BUI, MARILYN M.; ZUCCARI, DEBORA A. P. C.; et al. Multiparametric MRI and Coregistered Histology Identify Tumor Habitats in Breast Cancer Mouse Models. Cancer Research, v. 79, n. 15, p. 3952-3964, AUG 1 2019. Web of Science Citations: 1. (15/18541-3)
MARQUES, JESSICA H. M.; MOTA, ANDRE L.; OLIVEIRA, JESSICA G.; LACERDA, JESSICA Z.; STEFANI, JULIA P.; FERREIRA, LIVIA C.; CASTRO, TIALFI B.; ARISTIZABAL-PACHON, ANDRES F.; ZUCCARI, DEBORA A. P. C.. Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies. Life Sciences, v. 208, p. 131-138, SEP 1 2018. Web of Science Citations: 4. (16/14280-3, 15/04780-6)
DE CASTRO, TIALFI BERGAMIN; BORDIN-JUNIOR, NEWTON ANTONIO; DE ALMEIDA, EDUARDO ALVES; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Evaluation of melatonin and AFMK levels in women with breast cancer. ENDOCRINE, v. 62, n. 1, p. 242-249, OCT 2018. Web of Science Citations: 2. (15/02935-2)
JARDIM-PERASSI, BRUNA VICTORASSO; ALEXANDRE, PAMELA A.; SONEHARA, NATHALIA M.; DE PAULA-JUNIOR, RUBENS; REIS JUNIOR, OSVALDO; FUKUMASU, HEIDGE; CHAMMAS, ROGER; COUTINHO, LUIZ LEHMANN; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. RNA-Seq transcriptome analysis shows anti-tumor actions of melatonin in a breast cancer xenograft model. SCIENTIFIC REPORTS, v. 9, JAN 30 2019. Web of Science Citations: 2. (14/13815-5)
COLOMBO, JUCIMARA; JARDIM-PERASSI, V, BRUNA; FERREIRA, JOAO P. S.; BRAGA, CRISTINE Z.; SONEHARA, NATHALIA M.; RUBENS, P. JUNIOR; MOSCHETTA, MARINA G.; GIROL, MA P.; ZUCCARI, DEBORA A. P. C.. Melatonin Differentially Modulates NF-kappa B Expression in Breast and Liver Cancer Cells. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 18, n. 12, p. 1688-1694, 2018. Web of Science Citations: 2. (14/25661-2)
(References retrieved automatically from State of São Paulo Research Institutions)
ZUCCARI, Debora Aparecida Pires de Campos. Estudo imunocitoquímico de marcadores diagnósticos e prognósticos em neoplasias mamárias caninas. . 92f. Tese (Doutorado) – . Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal. (98/15634-3)
ZUCCARI, Debora Aparecida Pires de Campos. Contribuição ao estudo imunoistoquímico de tumores mamários em cadelas. 2014. 121f. Dissertação (Mestrado) - . Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal. (96/07908-0)