Heloisa Sobreiro Selistre de Araújo

• Abstract

  Integrins are heterodimeric cell surface receptors that connect cells to the extracellular matrix (ECM) and control various processes such as cell migration, cytoskeletal organization, cell polarity, metalloprotease activity, collagen synthesis, and migration direction. The pattern of integrin expression may be greatly altered in cells that underwent tumor transformation when compared to …

  Integrin molecular mechanisms of action during tumor progression and metastasis development: an intercellular approach, AP.R

• Abstract

  The extracellular matrix (ECM) is the structural scaffold for body tissues, and it is formed by a complex network of macromolecules such as collagens, glycosaminoglycans and proteoglycans. The ECM supports tissue volume, size and strength, and it is the basis for cell growth, division, and migration. However, ECM function is beyond structural and mechanical support. The ECM actively modul…

  The extracellular matrix in aging, exercise and in the tumor microenvironment, AP.TEM
• Aging-related alterations in extracellular matrix and its adaptations to strength training in calcaneal tendon of rats: molecular, cellular, and biomechanical approach, AP.R

(Only some records are available in English at this moment)

• Abstract

  Integrins are heterodimeric cell surface receptors that connect cells to the extracellular matrix (ECM) and control diverse processes such as cell migration, cytoskeleton organization and direction of migration. The pattern of integrin expression may be significantly altered in cells that have undergone tumor transformation when compared to that of normal cells. Integrin-mediated signalin…

  IN VIVO STUDIES OF THE ANTITUMORAL ACTIVITY OF AN avb3 INTEGRIN INHIBITOR, BP.IC

• Abstract

  Breast cancer is a heterogeneous disease with a high incidence in the femalepopulation and with the highest mortality rate among women in Brazil. Tumors thatexpress some type of hormone receptor respond favorably to existing therapies;however, triple-negative tumors, which do not contain them, are difficult to treat. Theinsufficient response of triple-negative tumors to therapeutic resour…

  In vivo studies on the effects of ²3 integrin subunit silencing in murine breast cancer, BP.IC

• Abstract

  A great part of the total mass in a tumor microenvironment comprises recruited macrophages,which may act in pro- or anti-tumoral responses depending on its interaction with the microenvironment. M2 macrophages are essential for metastatic processes, contributing to a pro-angiogenic and invasive context. In tumor cells, particularly under stress situations such as hypoxia, the communicatio…

  DIFFERENTIATION OF MACROPHAGES BY EXTRACELLULAR VESICLES DERIVED FROM HYPOXIA-CULTURED BREAST CANCER CELLS, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Extracellular vesicles (EVs) are nano-scaled particles secreted by cells that offer stable transport and storage of biomolecules. Their structure allows them to be taken up by other cells, thus turning EVs as potential candidates for new therapeutical approaches, particularly in drug delivery. To fully comprehend how EVs perform in a therapeutic setting, knowledge on cargo loading mechani…

  Interspecies interaction and uptake mechanism of extracellular vesicles with tropism to B cells, BE.EP.DD

• Abstract

  The ability of cells to adhere to each other and to the extracellular matrix is essential for the formation of tissues and organs. Among the different classes of adhesion molecules, integrins stand out because they bind to proteins associated with cytoskeletal linkage and signaling molecules, promoting mechanical signals. Besides these adhesion molecules are involved in normal cellular fu…

  The role of integrin ±2²1 in breast cancer metastasis to bone, BE.EP.DR

• Abstract

  Cancer is a serious human health problem worldwide. Metastasis is responsible for as much as 90% of cancer-associated mortality, and remains as the most poorly understood component of cancer pathogenesis. Tumor cells are capable to proliferate and create a microenviroment, as well as migrate to distant sites by a cross talk with the surrounding environment. In the last years, evidence is …

  The role of integrins on exosome binding to the extracellular matrix and its contribution to tumor progression, BE.EP.PD

(Only some records are available in English at this moment)