CV Lattes
GoogleMyCitations
ResearcherID
ORCID
Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Medicine from the Faculty of Medicine of the University of São Paulo (1984) and doctorate in Physiology and Biophysics from the Institute of Biomedical Sciences at USP (1995). He is currently an associate professor at the Faculty of Medicine of the University of São Paulo. He works at FMUSP, Hospital das Clínicas, FMUSP and Hospital Universitário, FMUSP. He has experience in the field of Medicine, with an emphasis on Clinical Emergencies. The central area of research is sepsis involving the following sub-themes, divided into two major sectors: 1- Septic shock, inflammation, tissue damage, multiple organ failure, metabolic changes, production of free radicals and activation of PARP; 2- in another line, there are studies on LPS tolerance, immunological regulation, gene expression and lymphocyte apoptosis / necrosis. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Sepsis, SIRS and septic shock are responsible for 30-45% of death in ICU. The treatment is based only in hemodynamic support and source control. The cytokines induces the release of many others inflammatory mediators, as for instance reactive oxygen species, and nitric oxide. Toll-like (TLR) inhibitors, antinflammatory cytokines and changes in TLR signaling are the mechanism that control …
Spontaneous hypothermia in septic patients is frequently fought off with active rewarming, but this practice is not evidence-based. Moreover, the need for rewarming patients from hypothermia in this case has been recently questioned by a study showing that septic hypothermia is a transient, self-limiting and non-terminal response. Here, we propose a prospective, interventional trial to as…
Sepsis, SIRS and septic shock are responsible for 30-45% of death in ICU. The treatment is based only in hemodynamic support and source control. SIRS causes tissue and organ damage even in organs not involved in the infectious process, vasodilatation, myocardic depression, and tissular hupoperfusion, disseminated intravascular coagulation state known as severe sepsis and septic shock. The…
Bacteria clearence is determinat of clincial outcome. A deficient immune system allow bacterai grow and invasion, on the other side, an excessive inflammatory response will dammage organ and tissues.Lymphocyte apoptosis has been related to an unfavorable outcome of patients. Blymphocytes are responsable for a specific action against antigens with memory development.B-1 are a subclass of B…
(Only some records are available in English at this moment)
The binding of LPS to TLR4 trigger the activation of cascades signaling breaks out a powerful inflammatory response to eliminate bacteria. However, the sequence and routes activated by LPS are not phenomena linear and continuous. Studies using different experimental models of endotoxemia have shown that a first exposure to low doses LPS can lead to tolerance of animals when exposed to a s…
Sepsis is known as a systemic inflammatory syndrome in response to an infection. It is a serious illness which can cause multiple organ failure and is currently the leading cause of death in patients admitted to Intensive Care Unit. Infection by gram-negative bacteria represents most of the recorded cases of Sepsis. The lipopolysaccharide (LPS) of the bacterial outer membrane component in…
Stem Cells (SCs) are cells with high proliferation capacity, self-renewal and ability to differentiate into more specialized cell lines. Adult CTs, such as Mesenchymal Stem Cells (MSCs) are of great interest for regenerative medicine, mainly in replacement tissues and transplants, such as bone marrow. MSCs are easy to obtain and have high proliferative capacity in vitro. These cells offer…
(Only some records are available in English at this moment)
Cancer development is a complex process involving diverse tissue types of distinct developmental origins, cell-cell interactions, and a myriad of signaling pathways. Cancer can evolve from a combination of epigenetic and genetic abnormalities resulting in dysregulated gene expression and function. Cells in nearly any part of the body can become cancer. Acute myeloid leukemia (AML) is one …
Multiple studies implicated H2S in many physiological processes, as well as in various forms of neurological, cardiovascular, metabolic diseases, and in critical illness. The biological character of H2S in health and disease is determined by a complex interplay between three factors: (1) expression/activity of H2S-producing enzymes; (2) redox status and reactive oxygen/nitrogen species pr…
| 1 / 1 | Ongoing research grants |
| 7 / 5 | Completed research grants |
| 16 / 12 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 27 / 20 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 12 |
| Citations | 87 |
| Cit./Article | 7.2 |
| Data from Web of Science | |
GUIDO, MARIA C.; CLEMENTE, CAROLINA F.; MORETTI, ANA I.; BARBEIRO, HERMES V.; DEBBAS, VICTOR; CALDINI, ELIA G.; FRANCHINI, KLEBER G.; SORIANO, FRANCISCO G.. SMALL INTERFERING RNA TARGETING FOCAL ADHESION KINASE PREVENTS CARDIAC DYSFUNCTION IN ENDOTOXEMIA. Shock, v. 37, n. 1, p. 77-84, JAN 2012. Web of Science Citations: 5. (06/00443-6)
MELO, EDIELLE SANT'ANNA; BARBEIRO, DENISE F.; GORJAO, RENATA; SARMENTO RIOS, ESTER CORREIA; VASCONCELOS, DEWTON; VELASCO, IRINEU T.; SZABO, CSABA; CURI, RUI; DE LIMA-SALGADO, THAIS MARTINS; SORIANO, FRANCISCO GARCIA. Gene expression reprogramming protects macrophage from septic-induced cell death. Molecular Immunology, v. 47, n. 16, p. 2587-2593, OCT 2010. Web of Science Citations: 17.
SORIANO, FRANCISCO GARCIA; GUIDO, MARIA CAROLINA; BARBEIRO, HERMES VIEIRA; CALDINI, ELIA GARCIA; LORIGADOS, CLARA BATISTA; NOGUEIRA, ANTONIO CARLOS. ENDOTOXEMIC MYOCARDIAL DYSFUNCTION: SUBENDOCARDIAL COLLAGEN DEPOSITION RELATED TO CORONARY DRIVING PRESSURE. Shock, v. 42, n. 5, p. 472-479, NOV 2014. Web of Science Citations: 7. (09/15530-0)
PETRONI, RICARDO COSTA; TEODORO, WALCY R.; GUIDO, MARIA CAROLINA; BARBEIRO, HERMES VIEIRA; ABATEPAULO, FATIMA; THEOBALDO, MARIANA CARDILLO; BISELLI, PAOLO CESARE; SORIANO, FRANCISCO GARCIA. ROLE OF FOCAL ADHESION KINASE IN LUNG REMODELING OF ENDOTOXEMIC RATS. Shock, v. 37, n. 5, p. 524-530, MAY 2012. Web of Science Citations: 7. (06/00443-6, 09/03338-7)
CAPPI, SYLAS B.; NORITOMI, DANILO T.; VELASCO, IRINEU T.; CURI, RUI; LOUREIRO, TATIANA C. A.; SORIANO, FRANCISCO G.. Dyslipidemia: a prospective controlled randomized trial of intensive glycemic control in sepsis. Intensive Care Medicine, v. 38, n. 4, p. 634-641, APR 2012. Web of Science Citations: 17.
THEOBALDO, MARIANA CARDILLO; LLIMONA, FLAVIA; PETRONI, RICARDO COSTA; RIOS, ESTER CORREIA SARMENTO; VELASCO, IRINEU TADEU; SORIANO, FRANCISCO GARCIA. Hypertonic Saline Solution Drives Neutrophil from Bystander Organ to Infectious Site in Polymicrobial Sepsis: A Cecal Ligation and Puncture Model. PLoS One, v. 8, n. 9, SEP 17 2013. Web of Science Citations: 10. (09/15530-0)
PIMENTEL, ROSANGELA NASCIMENTO; PETRONI, RICARDO COSTA; BARBEIRO, HERMES VIEIRA; BARBEIRO, DENISE FREDIANI; ANDRADE, MARIANA MACEDO; ARIGA, SUELY KUMINI; SORIANO, FRANCISCO GARCIA. Hypertonic solution-induced preconditioning reduces inflammation and mortality rate. Journal of Inflammation-London, v. 16, JUL 3 2019. Web of Science Citations: 0. (15/04138-2, 09/03338-7)
ARIGA, SUELY KUBO; ABATEPAULO, FATIMA BERNARDES; ANNA MELO, EDIELLE SANT; VELASCO, IRINEU TADEU; DA SILVA, FABIANO PINHEIRO; DE LIMA, THAIS MARTINS; SORIANO, FRANCISCO GARCIA. ENDOTOXIN TOLERANCE DRIVES NEUTROPHIL TO INFECTIOUS SITE. Shock, v. 42, n. 2, p. 168-173, AUG 2014. Web of Science Citations: 2.
SORIANO‚ F.G.; NOGUEIRA‚ A.C.; CALDINI‚ E.G.; LINS‚ M.H.; TEIXEIRA‚ A.C.; CAPPI‚ S.B.; LOTUFO‚ P.A.; BERNIK‚ M.; ZSENGELLÉR‚ Z.; CHEN‚ M.; et al. Potential role of poly (adenosine 5’-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock. Critical Care Medicine, v. 34, n. 4, p. 1073, 2006.
MELO‚ E.S.; GOLOUBKOVA‚ T.; BARBEIRO‚ D.F.; GORJÃO‚ R.; VASCONCELOS‚ D.; SZABO‚ C.; CURI‚ R.; DE LIMA SALGADO‚ T.M.; VELASCO‚ I.T.; SORIANO‚ F.G.. Endotoxin tolerance: Selective alterations in gene expression and protection against lymphocyte death. Immunobiology, v. 215, n. 6, p. 435-442, 2010. Web of Science Citations: 5.
SARMENTO RIOS, ESTER CORREIA; DE LIMA, THAIS MARTINS; SOARES MORETTI, ANA IOCHABEL; SORIANO, FRANCISCO GARCIA. The role of nitric oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide. Life Sciences, v. 147, p. 110-116, FEB 15 2016. Web of Science Citations: 5. (09/16288-8)
FONSECA, MONIQUE T.; RODRIGUES, ABNER C.; CEZAR, LUANA C.; FUJITA, ANDRE; SORIANO, FRANCISCO G.; STEINER, ALEXANDRE A.. Spontaneous hypothermia in human sepsis is a transient, self-limiting, and nonterminal response. Journal of Applied Physiology, v. 120, n. 12, p. 1394-1401, JUN 15 2016. Web of Science Citations: 10. (11/50761-2, 14/09576-5, 09/15530-0, 12/03831-8, 13/00506-1)
LORIGADOS, CLARA B.; ARIGA, SUELY K. K.; DE LIMA, THAIS M.; BARBEIRO, DENISE F.; KRIEGER, JOSE E.; SORIANO, FRANCISCO G.. BONE MARROW CELLS TRANSPLANT IN SEPTIC MICE MODULATES SYSTEMIC INFLAMMATORY RESPONSE VIA CELL-CELL CONTACT. Shock, v. 51, n. 3, p. 381-388, MAR 2019. Web of Science Citations: 2. (15/04138-2, 09/03338-7)
(References retrieved automatically from State of São Paulo Research Institutions)
JEREMIAS, Isabela Casagrande. Investigação das alterações imunológicas em camundongos submetidos ao modelo animal de sepse por ligação e perfuração cecal (CLP) com alterações cerebrais. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (12/07898-0)
PETRONI, Ricardo Costa. Papel da solução salina hipertônica (NaCl 7,5%) no remodelamento pulmonar da endotoxemia induzida por lipopolissacarídeos. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (09/07478-8)
SILVA, André Augusto Botêga. Alterações funcionais de mitocondrias hepáticas na tolerância ao lipopolissacarídeo (LPS). Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (14/11743-7)
RIOS, Ester Correia Sarmento. Efeito da solução hipertônica (NaCI 7,5%) no estresse oxidativo e nos processos de morte celular e remodelamento tecidual hepático em pancreatite aguda experimental. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (05/60593-9)