- Research Grants
Dr. Melo is graduated in Biological Sciences from the University of Campinas (1990), Master and PhD in Biological Sciences from the University of Campinas in 1994 and 1998, respectively. During her PhD, she was a fellow at the Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA. From 2001 to 2007 she was professor at the Faculty of Medical Sciences, Santa Casa de São Paulo and is currently a researcher at the Center of Molecular Biology and Genetic Engineering (CBMEG - UNICAMP). Dr. Melo has research experience in the area of Human and Medical Genetics, specially on the following themes: genetics in hematology and ophthalmology. (Source: Lattes Curriculum)
This new Multi-PI thematic project proposal will be conducted by the Red Blood Cell Research Group, which is formed by researchers from the Hemocentro (Blood Center), the Department of Clinical Pathology, School of Medical Sciences and the Molecular Biology and Genetic Engineering Center (CBMEG) at UNICAMP, in collaboration with several Brazilian and international researchers. The new p...
The sickle cell disease (SCD) are a group of genetic disorders that have in common that the presence of hemoglobin (Hb) S, a mutant protein that undergoes polymerization under low oxygen tensions, generating vaso-occlusion. The obstruction and the lesion of the vascular endothelium and tissue cause an inflammatory response that in turn results in a chronic inflammatory state in patients...
Although Sickle Cell Anemia (SCA) results from homozygosity of a single mutation at position 6 of the beta-globin locus, the clinical aspect of this disease is very heterogeneous, and hence different patients can have significantly different clinical manifestations. Almost all organs can be affected by the vascular occlusion. Leg ulcer is one of the worst complications, exerting highly ...
(Only some records are available in English at this moment)
Glaucoma is a neurodegenerative disease of multifactorial etiology that includes several eye disorders whose common features are the progressive damage of the optic nerve with vision loss. It is a major cause of irreversible blindness in the world. Primary open angle glaucoma (POAG) is the most common type of the disease, while Juvenile Open Angle Glaucoma (JOAG) is an earlier onset and...
Although sickle cell anemia (SCA) results from the homozygosity of a single mutation in amino acid 6 of the ²-globin locus, this disease presents high phenotypic heterogeneity, so that different patients may have significantly different clinical outcomes. Vascular occlusion occurs systemically, and transient ischemic attacks, stroke and cerebral hemorrhage affect approximately 25% of pa...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
CRUZ, Pedro Rodrigues Sousa da. Avaliação das variações no número de cópias (CNVs) na susceptibilidade ao acidente vascular cerebral em pacientes com anemia falciforme = Copy number variations (CNVs) in the assessment of stroke susceptibility in patients with sickle cell anemia. 2016. Tese (Doutorado) – Universidade Estadual de Campinas, Instituto de Biologia.
BRAGHINI, Carolina Ayumi. Avaliação de alelos mutantes dos genes MYOC E CYYP1B1 em pacientes portadores de glaucoma primário de ângulo aberto. 2012. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP).
CRUZ, Pedro Rodrigues Sousa da. Análise bioquímica e genética das vias de adesão celular e crescimento vascular : associação com o desenvolvimento de retinopatia falciforme. 2012. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP).
ARAUJO, Ana Luiza de. Estudo de mutações nos genes CX46, CX50 e HSF4 em pacientes com catarata congênita. 2015. Dissertação (Mestrado) -
SVIDNICKI, Paulo Vinicius. Análise de aspectos genéticos do glaucoma primário de ângulo aberto juvenil. 2018. Tese (Doutorado) – Universidade Estadual de Campinas, Faculdade de Ciências Médicas.
NUNES, Hugo Freire. Aspectos genéticos do glaucoma primário de ângulo aberto na população brasileira = Genetic aspects of primary open angle glaucoma in Brazilian population. 2016. Tese (Doutorado) – Universidade Estadual de Campinas, Instituto de Biologia.