Abstract
Richieri-Costa-Pereira syndrome (RCPS) is a congenital craniofacial malformation originated from disturbances in embryonic craniofacial development. RCPS is caused by loss-of-function mutations in EIF4A3, which acts in basic cellular functions such as mRNA splicing and nonsense-mediated decay. Development of the craniofacial complex is dependent upon morphogenetic stages orchestrated by c…