CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Medicina from Universidade de São Paulo (1957) and ph.d. at Physiology from Universidade de São Paulo (1960). Has experience in Physiology, focusing on Renal Physiology, acting on the following subjects: bicarbonato, h-atpase, potassio, ph celular and microperfusao. (Source: Lattes Curriculum)
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Summary of Project.The presente Project involves transfer mechanisms of H+ and K+ across renal epithelium and their regulation. Transport of potassium, e major ion responsible for regulation and maintenance of cellular and luminal concentrations, will be studied, particularly from the point of view of proximal reabsorption, thought to be mainly passive via the paracellular path, but tha…
The sub-projects outlined in the present Thematic Project proposal all involve studying the transport of ions through cell membranes. With the exception of two that analyze 1) other aspects of glomerular cells and 2) the transport of the neutral molecule NH3 through cells involved with ammonia ammonia (NH3/NH4+) homeostasis or transport, such as the hepatocytes and collecting duct cells. …
The present project will investigate ion transport mechanism (Na+, K+, H+) in different nephron segments. We will investigate mechanisms that affect mainly proximal and distal tubules. We will investigate the effect of hormones (Aldosterone, GLP-1, AVP, AG 1,7), transcription factors, physiological and pathophysiologycal conditions (water deprivation, post-prandial period, potassion loadi…
(Only some records are available in English at this moment)
Acetazolamide is a diuretic that acts by inhibiting the carbonic anhydrase enzyme present in the proximal tubule of the nephron. The enzyme carbonic anhydrase acts by converting water and CO2 into carbonic acid (H2CO3), which ionizes into H+ and HCO3-, so its inhibition reduces the concentration of both and leads to the excretion of Na+ and water. Potassium (K+) is the main ion of the int…
The Renin Angiotensin System (RAS) is a regulator of the cardiovascular system and the electrolyte balance. A new component of the system has recently been identified, an alamandine, a heptapeptide generated by the catalytic action of the angiotensin-converting enzyme 2 or directly from Angiotensin-(1-7) [Ang-(1-7)]. Alamandine produces several physiological actions similar to those produ…
Potassium is responsible for maintaining some of the basic functions of the cell, such as membrane potential. Its transport is executed by interactions between Na+/K+-ATPase and many other transport processes, which include channels for sodium and potassium, the paracellular path as well as cotransporters and counter-transporters of potassium. These processes are meant to avoid major dist…
(Only some records are available in English at this moment)
Alamandine, a new component of the renin-angiotensin system has been recently identified and characterized and the Mas-related G-protein coupled receptor member D (MrgD) recognized as its receptor. Although cardioprotective effects of alamandine have been described, the significance of this peptide in renal function and kidney pathology, specifically in acute kidney injury (AKI) has not b…
| 31 / 14 | Completed research grants |
| 18 / 7 | Completed scholarships in Brazil |
| 3 / 1 | Completed scholarships abroad |
| 52 / 22 | All research grants and scholarships |
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