Gerhard Malnic
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Áustria
graduate at Medicina from Universidade de São Paulo (1957) and ph.d. at Physiology from Universidade de São Paulo (1960). Has experience in Physiology, focusing on Renal Physiology, acting on the following subjects: bicarbonato, h-atpase, potassio, ph celular and microperfusao. (Source: Lattes Curriculum)
- Regulation of h and K transport in renal tubules, AP.R
Abstract
Summary of Project.The presente Project involves transfer mechanisms of H+ and K+ across renal epithelium and their regulation. Transport of potassium, e major ion responsible for regulation and maintenance of cellular and luminal concentrations, will be studied, particularly from the point of view of proximal reabsorption, thought to be mainly passive via the paracellular path, but t...
- Molecular and functional study of membrane transporters, AP.TEM
Abstract
The sub-projects outlined in the present Thematic Project proposal all involve studying the transport of ions through cell membranes. With the exception of two that analyze 1) other aspects of glomerular cells and 2) the transport of the neutral molecule NH3 through cells involved with ammonia ammonia (NH3/NH4+) homeostasis or transport, such as the hepatocytes and collecting duct cells...
- Renal transport of solutes and water: effect of hormones, drugs and pathophysiology, AP.R
Abstract
The present project will investigate ion transport mechanism (Na+, K+, H+) in different nephron segments. We will investigate mechanisms that affect mainly proximal and distal tubules. We will investigate the effect of hormones (Aldosterone, GLP-1, AVP, AG 1,7), transcription factors, physiological and pathophysiologycal conditions (water deprivation, post-prandial period, potassion loa...
- Molecular and functional study of ion transporters in membranes, AP.TEM
Abstract
This thematic project includes projects having in common the study of ion transporters in membranes. Most of these projects focalize the study of epithelial cells of the kidney, with the exception of two, which analyze glial neurons/cells and osteoclasts. In neurons, the effect of phenylpropenes on voltage sensitive sodium channels will be investigated, and in glial cells, purinergic me...
(Only some records are available in English at this moment)
- Effect of acetazolamide on potassium reabsorption in the proximal tubule, BP.IC
Abstract
Acetazolamide is a diuretic that acts by inhibiting the carbonic anhydrase enzyme present in the proximal tubule of the nephron. The enzyme carbonic anhydrase acts by converting water and CO2 into carbonic acid (H2CO3), which ionizes into H+ and HCO3-, so its inhibition reduces the concentration of both and leads to the excretion of Na+ and water. Potassium (K+) is the main ion of the i...
- The effects of the Alamandine on the Na+/H+ exchanger in in vivo proximal tubule of spontaneously hypertensive rats, BP.PD
Abstract
The Renin Angiotensin System (RAS) is a regulator of the cardiovascular system and the electrolyte balance. A new component of the system has recently been identified, an alamandine, a heptapeptide generated by the catalytic action of the angiotensin-converting enzyme 2 or directly from Angiotensin-(1-7) [Ang-(1-7)]. Alamandine produces several physiological actions similar to those pro...
- Potassium transport though paracellular pathway in rat’s proximal tubules: the paper of claudins, BP.IC
Abstract
Potassium is responsible for maintaining some of the basic functions of the cell, such as membrane potential. Its transport is executed by interactions between Na+/K+-ATPase and many other transport processes, which include channels for sodium and potassium, the paracellular path as well as cotransporters and counter-transporters of potassium. These processes are meant to avoid major di...
- Role of the proximal tubule Na+/H+ exchanger isoform 3 in the acute sodium and water retention after 24 hours of water deprivation: aresponse to arginine vasopressin ou to the renin-angiotensin-aldosterone system?, BP.PD
Abstract
The renal system is important to the osmolarity balance of the extravascular fluid and one of the most important systems related to the control of the extracellular fluid volume and the arterial pressure.The renal control of osmolarity is achieved through a complex mechanism able to secrete water or retain it depending on the needs of the body. This function is performed by arginine-vas...
- Effects of simvastatin and sildenafil on NHE3 activity, BP.DR
Abstract
The drugs Sildenafil and Simvastatin modulate the activity of proteins and molecules involved in intracellular signaling. Simvastatin is a molecule of the statins family, which are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. In addition to this function, it's also currently assigned to Simvastatin via an inhibitory effect on the GTPase Rho (family of proteins that inc...
(Only some records are available in English at this moment)
- Role of ALAMANDINE/MrgD interaction in acute kidney injury, BE.EP.PD
Abstract
Alamandine, a new component of the renin-angiotensin system has been recently identified and characterized and the Mas-related G-protein coupled receptor member D (MrgD) recognized as its receptor. Although cardioprotective effects of alamandine have been described, the significance of this peptide in renal function and kidney pathology, specifically in acute kidney injury (AKI) has not...
| 1 / 1 | Ongoing research grants |
| 30 / 13 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 16 / 5 | Completed scholarships in Brazil |
| 3 / 1 | Completed scholarships abroad |
| 52 / 22 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 13 |
| Citations | 303 |
| Cit./Article | 23.3 |
| Data from Web of Science | |
GIRARDI, ADRIANA CASTELLO COSTA; FUKUDA, LÍVIA EMY; ROSSONI, LUCIANA VENTURINI; MALNIC, GERHARD; REBOUÇAS, NANCY AMARAL. Dipeptidyl peptidase IV inhibition downregulates Na+-H+ exchanger NHE3 in rat renal proximal tubule. American Journal of Physiology : Renal Physiology, v. 294, n. 2, p. F414-F422, Feb. 2008. (04/01683-5)
CRAJOINAS, RENATO O.; ORICCHIO, FELIPE T.; PESSOA, THAISSA D.; PACHECO, BRUNA P. M.; LESSA, LUCILIA M. A.; MALNIC, GERHARD; GIRARDI, ADRIANA C. C.. Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 301, n. 2, p. F355-F363, AUG 2011. Web of Science Citations: 114.
CARRARO-LACROIX, LUCIENE R.; LESSA, LUCILIA M. A.; BEZERRA, CAMILA N. A.; PESSOA, THAISSA D.; SOUZA-MENEZES, JACKSON; MORALES, MARCELO M.; GIRARDI, ADRIANA C. C.; MALNIC, GERHARD. Role of CFTR and ClC-5 in Modulating Vacuolar H+-ATPase Activity in Kidney Proximal Tubule. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 26, n. 4-5, p. 563-576, 2010. Web of Science Citations: 16. (04/01683-5)
THIEME, KARINA; OLIVEIRA-SOUZA, MARIA. Renal Hemodynamic and Morphological Changes after 7 and 28 Days of Leptin Treatment: The Participation of Angiotensin II via the AT(1) Receptor. PLoS One, v. 10, n. 3, MAR 20 2015. Web of Science Citations: 9. (13/23087-4, 08/58287-5, 13/19569-3, 10/19656-5)
QUEIROZ-LEITE, GABRIELLA D.; CRAJOINAS, RENATO O.; NERI, ELIDA A.; BEZERRA, CAMILA N. A.; GIRARDI, ADRIANA C. C.; REBOUCAS, NANCY AMARAL; MALNIC, GERHARD. Fructose Acutely Stimulates NHE3 Activity in Kidney Proximal Tubule. Kidney & Blood Pressure Research, v. 36, n. 1, p. 320-334, 2012. Web of Science Citations: 17. (08/58287-5)
CARDOSO, VANESSA GEROLDE; GONCALVES, GUILHERME LOPES; COSTA-PESSOA, JULIANA MARTINS; THIEME, KARINA; LINS, BRUNA BEZERRA; MALAVAZZI CASARE, FERNANDO AUGUSTO; DE PONTE, MARIANA CHARLEAUX; SARAIVA CAMARA, NIELS OLSEN; OLIVEIRA-SOUZA, MARIA. Angiotensin II-induced podocyte apoptosis is mediated by endoplasmic reticulum stress/PKC-delta/p38 MAPK pathway activation and trough increased Na+/H+ exchanger isoform 1 activity. BMC Nephrology, v. 19, JUL 13 2018. Web of Science Citations: 7. (13/19569-3, 17/02020-0, 14/19154-0, 13/23087-4, 14/17251-9, 11/14022-0)
LEITE-DELLOVA, DEISE C. A.; SZRIBER, SHIRLEY J.; MERIGHE, GIOVANA K. F.; POLIDORO, JULIANO Z.; REBOUCAS, NANCY A.; OLIVEIRA-SOUZA, MARIA; DE MELLO-AIRES, MARGARIDA. Signaling pathways involved in the rapid biphasic effect of aldosterone on Na+/H(+)exchanger in rat proximal tubule cells. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, v. 182, p. 87-94, SEP 2018. Web of Science Citations: 2. (17/02020-0, 13/23087-4, 11/19967-3, 13/19569-3)
DE PONTE, MARIANA CHARLEAUX; MALAVAZZI CASARE, FERNANDO AUGUSTO; COSTA-PESSOA, JULIANA MARTINS; CARDOSO, VANESSA GEROLDE; MALNIC, GERHARD; MELLO-AIRES, MARGARIDA; VOLPINI, RILDO APARECIDO; THIEME, KARINA; OLIVEIRA-SOUZA, MARIA. The Role of beta-Adrenergic Overstimulation in the Early Stages of Renal Injury. Kidney & Blood Pressure Research, v. 42, n. 6, p. 1277-1289, 2017. Web of Science Citations: 1. (13/23087-4, 14/17251-9, 11/14022-0, 14/19154-0)
KABUTOMORI, JESSICA; BELOTO-SILVA, OLIVIA; GEYER, R. RYAN; MUSA-AZIZ, RAIF. Lithobates catesbeianus (American Bullfrog) oocytes: a novel heterologous expression system for aquaporins. BIOLOGY OPEN, v. 7, n. 4, APR 2018. Web of Science Citations: 0. (13/11364-3, 13/23087-4, 13/10780-3)
NERI, ELIDA ADALGISA; ALVES BEZERRA, CAMILA NOGUEIRA; QUEIROZ-LEITE, GABRIELLA DUARTE; POLIDORO, JULIANO ZEQUINI; REBOUCAS, NANCY AMARAL. Parathyroid hormone inhibition of Na+/H+ exchanger 3 transcription: Intracellular signaling pathways and transcription factor expression. Biochemical and Biophysical Research Communications, v. 461, n. 4, p. 582-588, JUN 12 2015. Web of Science Citations: 1. (13/23087-4, 08/58287-5)
THIEME, KARINA; OLIVEIRA-SOUZA, MARIA. Renal Hemodynamic and Morphological Changes after 7 and 28 Days of Leptin Treatment: The Participation of Angiotensin II via the AT(1) Receptor. PLoS One, v. 10, n. 3, MAR 20 2015. Web of Science Citations: 9. (13/23087-4, 08/58287-5, 13/19569-3, 10/19656-5)
CARDOSO, VANESSA GEROLDE; GONCALVES, GUILHERME LOPES; COSTA-PESSOA, JULIANA MARTINS; THIEME, KARINA; LINS, BRUNA BEZERRA; MALAVAZZI CASARE, FERNANDO AUGUSTO; DE PONTE, MARIANA CHARLEAUX; SARAIVA CAMARA, NIELS OLSEN; OLIVEIRA-SOUZA, MARIA. Angiotensin II-induced podocyte apoptosis is mediated by endoplasmic reticulum stress/PKC-delta/p38 MAPK pathway activation and trough increased Na+/H+ exchanger isoform 1 activity. BMC Nephrology, v. 19, JUL 13 2018. Web of Science Citations: 7. (13/19569-3, 17/02020-0, 14/19154-0, 13/23087-4, 14/17251-9, 11/14022-0)
KABUTOMORI, JESSICA; BELOTO-SILVA, OLIVIA; GEYER, R. RYAN; MUSA-AZIZ, RAIF. Lithobates catesbeianus (American Bullfrog) oocytes: a novel heterologous expression system for aquaporins. BIOLOGY OPEN, v. 7, n. 4, APR 2018. Web of Science Citations: 0. (13/11364-3, 13/23087-4, 13/10780-3)
CARRARO-LACROIX, LUCIENE R.; LESSA, LUCILIA M. A.; BEZERRA, CAMILA N. A.; PESSOA, THAISSA D.; SOUZA-MENEZES, JACKSON; MORALES, MARCELO M.; GIRARDI, ADRIANA C. C.; MALNIC, GERHARD. Role of CFTR and ClC-5 in Modulating Vacuolar H+-ATPase Activity in Kidney Proximal Tubule. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 26, n. 4-5, p. 563-576, 2010. Web of Science Citations: 16. (04/01683-5)
QUEIROZ-LEITE, GABRIELLA D.; CRAJOINAS, RENATO O.; NERI, ELIDA A.; BEZERRA, CAMILA N. A.; GIRARDI, ADRIANA C. C.; REBOUCAS, NANCY AMARAL; MALNIC, GERHARD. Fructose Acutely Stimulates NHE3 Activity in Kidney Proximal Tubule. Kidney & Blood Pressure Research, v. 36, n. 1, p. 320-334, 2012. Web of Science Citations: 17. (08/58287-5)
LEITE-DELLOVA, DEISE C. A.; SZRIBER, SHIRLEY J.; MERIGHE, GIOVANA K. F.; POLIDORO, JULIANO Z.; REBOUCAS, NANCY A.; OLIVEIRA-SOUZA, MARIA; DE MELLO-AIRES, MARGARIDA. Signaling pathways involved in the rapid biphasic effect of aldosterone on Na+/H(+)exchanger in rat proximal tubule cells. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, v. 182, p. 87-94, SEP 2018. Web of Science Citations: 2. (17/02020-0, 13/23087-4, 11/19967-3, 13/19569-3)
DE PONTE, MARIANA CHARLEAUX; MALAVAZZI CASARE, FERNANDO AUGUSTO; COSTA-PESSOA, JULIANA MARTINS; CARDOSO, VANESSA GEROLDE; MALNIC, GERHARD; MELLO-AIRES, MARGARIDA; VOLPINI, RILDO APARECIDO; THIEME, KARINA; OLIVEIRA-SOUZA, MARIA. The Role of beta-Adrenergic Overstimulation in the Early Stages of Renal Injury. Kidney & Blood Pressure Research, v. 42, n. 6, p. 1277-1289, 2017. Web of Science Citations: 1. (13/23087-4, 14/17251-9, 11/14022-0, 14/19154-0)
(References retrieved automatically from State of São Paulo Research Institutions)
GONZÁLEZ, Ana Rosa Beltrán. Estudo da isoforma 4 do permutador Na+ / H+ em células T84: caracterização funcional e modulação pela enterotoxina termoestável de E. coli, STa. 155 f. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (01/00013-8)
PESSOA, Thaissa Dantas. Efeito da glicose e da atividade do co-transportador Na+-glicose, isoformas 1 e 2, sobre o trocador Na+/H+, isoforma 3 em túbulos proximais: papel do metabolismo glicolítico, do transporte de água e da localização dos transportadores.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (09/51772-8)
LIMA, Lucília Maria Abreu Lessa Leite. Efeito da uroguanilina sobre o transporte de hidrogênio em túbulos renais de rins de rato e em linhagens de células proximais e distrais. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (05/60491-1)
SANTOS, Priscilla Marys Costa dos. Efeitos da sinvastatina e do sildenafil na atividade do NHE3 em túbulos proximais de ratos wistar.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (13/16751-5)