Abstract
The drugs used in the leukemia treatment, as Elspar® and Erwinase®, use L-asparaginase by prokaryotic origin and the main disadvantage of its use are hypersensitivity reactions, sometimes fatal. The use of L- asparaginase eukaryotic origin (yeast and filamentous fungi) can have lower intensity of allergic reactions due to post-translational properties that occur in these micro-organisms. …