Abstract
Hypertensive disorders of pregnancy are one of the main causes of maternal and perinatal mortality worldwide. Pre-eclampsia is a multisystem disease characterized by intense activation of innate immunity components such as the NLRP3 inflammasome complex, which is responsible for the production of high levels of Interleukin-1 (IL-1²) and IL-18 in both placenta and peripheral blood. As a cl…