Abstract
We have demonstrated that the oxidation of uric acid occurs at the early events of Atherosclerosis and could be associated to vascular damage and progression of the disease. Oxidation of uric acid by peroxidases generates urate free radical and urate hydroperoxide. Urate hydroperoxide efficiently oxidizes the recombinant thiol-protein PDI (Protein Disulfide Isomerase), an important protei…