Bachelor's at Ciências Biológicas from Universidade de São Paulo (1988), master's at Biochemistry from Universidade de São Paulo (1991) and doctorate at Biochemistry from Universidade de São Paulo (1995). Has experience in Biochemistry and Molecular Biology, acting on the following subjects: gene expression, signal transduction, odorant receptors. (Source: Lattes Curriculum)
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The olfactory system plays a fundamental role in the interaction of living organisms with the surrounding environment, influencing aspects ranging from survival to sociability. The cells responsible for this interaction are Olfactory Sensory Neurons (OSNs), specialized neurons located in the Olfactory Epithelium (OE), which play a central role in odor detection. OSNs express a single olfa…
Odorants are recognized by a large family of odorant receptors (ORs), expressed in the olfactory neurons. The human OR family is composed of ~ 400 genes. In this project we aim to analyze four molecular aspects concerning the olfactory system: (1) We will analyze how variable is the repertoire of ORs of individuals from diverse geographical and cultural backgrounds. (2) Olfactory dysfunct…
Odorants activate odorant receptors (ORs) that are present in the cilia of the olfactory sensory neurons. Odorant receptors are G protein coupled receptors (GPCRs) and belong to a large family composed of approximately 1000 genes in the mouse, and 400 genes in humans. In this project, we aim to analyze two different aspects related to the function of these receptors: (1) Each olfactory se…
Mammals are able to discriminate a vast number of odorants through their sense of smell. In the nasal cavity there are millions of olfactory sensory neurons, which are responsible for this task. Odorants activate odorant receptors that are present in the cilia of the olfactory sensory neurons. The odorant receptors (ORs) belong to the G protein coupled receptor super family (GPCRs) and co…
Animais detect chemical cues that are present in the environment through a large family of receptors which belong to the G protein coupled receptors superfamily (GPCRs). These receptors are expressed in specialized cell types that are involved in different functions. Odorant receptors are expressed in the olfactory sensory neurons of the nose, taste receptors are expressed in the taste ce…
(Only some records are available in English at this moment)
The olfactory system plays a fundamental role in the interaction of living organisms with the surrounding environment, influencing aspects ranging from survival to sociability. The cells responsible for this interaction are Olfactory Sensory Neurons (OSNs), specialized neurons located in the Olfactory Epithelium (OE), which play a central role in odor detection. OSNs express a single olfa…
Humans have ~400 olfactory receptor genes, and thanks to them they are able to detect and discriminate thousands of odours. Although the number of ORs is very similar between different individuals, the sequences of human ORs are extremely variable in the population, which can cause differences in the way different individuals perceive odours. We plan to identify and analyse geographically…
(Only some records are available in English at this moment)
mTORC2 is an important protein complex that controls homeostasis, metabolism, cell growth and cell division. The mechanisms uderlying mTORC2 regulation remain however poorly understood. In previous works, we showed that mTORC2 (but not mTORC1) activation is dependent on Ric-8B expression. These results were verified both in cells knocked down (KD) for Ric-8B and in Ric-8B mutant mice. Th…
There are ~1000 Odorant Receptor (OR) genes in the mouse genome. Each olfactory sensory neuron expresses one allele from one single OR gene. The molecular mechanisms underlying OR gene expression is not understood. Our previous results have shown that olfactory neurons have a characteristic nuclear organization which differs from other cell types. Odorant receptor genes that are located o…
Olfactory receptors (ORs) act at the first step in odorant recognition. The mouse genome contains one thousand genes that code for ORs, but only one of these is expressed in each Olfactory Sensory Neuron. The mechanisms that regulate this peculiar pattern of expression are still unknown. This project aims to study OR gene regulatory elements by searching for conserved sequences in these r…
(Only some records are available in English at this moment)
In vitro, RIC-8B interacts with specific ± subunits of heterotrimeric G proteins, acting as both a molecular chaperone and a non-canonic guanine nucleotide exchange factor. Previous findings from our laboratory suggest that RIC-8B may regulate the activation of the olfactory G± subunit, G±olf. G±olf is abundantly expressed in olfactory neurons, where it couples to the heptahelical odorant…
| 2 / 2 | Ongoing research grants |
| 12 / 6 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 22 / 7 | Completed scholarships in Brazil |
| 3 / 1 | Completed scholarships abroad |
| 43 / 20 | All research grants and scholarships |
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CV Lattes
ORCID