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Antonio José da Costa Filho

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Sociedade Brasileira de Biofísica (SBBf)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Antonio José da Costa Filho received a Bachelor degree in Physics from the University of São Paulo (USP) in 1994. After that he started his Graduate program in the same university, concluding his Masters in 1996. His PhD project was developed both in São Carlos, under the supervision of Prof. Otaciro Nascimento, and in Ithaca (USA), where he spent 3 years as a visiting graduate student at Cornell University, working under Prof. Jack Freed´s supervision. During his PhD, Prof. Antonio Costa worked on the development of new electron magnetic resonance methods for the study of: (1) lipid-protein interactions, (2) the dynamic structure of lipid membranes, and (3) metal centers in protein structure. In 2001 he received his PhD degree in Physics from the University of São Paulo and started working as an Assistant Professor at USP (Campus São Carlos). He is currently Full Professor at USP-Ribeirão Preto and his research interests involve the investigation of interactions between biomolecules with emphasis on how the interaction between proteins and their ligands (substrates, inhibitors, and membranes) can lead to modulation of the protein function. More recently, he also got interested in the structural behavior of proteins involved in the unconventional secretory pathways of the cell, in particular the so-called Golgi Reassembly and Stacking Proteins (GRASPs). To accomplish those objectives his group makes use of a combined and interdisciplinary approach of experimental techniques, such as magnetic resonance, circular dichroism, and microcalorimetry. He has received several awards for his teaching skills as well as for contributions to his specific field of scientific interest. He is a Young Affiliate Alumnus of the Brazilian Academy of Sciences and of the World Academy of Sciences, former member and coordinator of the Advisory Committee of the Brazilian National Science Foundation (CNPq) on Biophysics/Biochemistry/Physiology/Pharmacology/Neurosciences, current President of the Brazilian Biophysical Society, and director of the Ribeirão Preto Institute for Advanced Studies of the University of São Paulo. (Source: Lattes Curriculum)

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FAPESP support in numbers * Updated February 22, 2020
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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (24)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications24
Citations122
Cit./Article5.1
Data from Web of Science

MENDES, LUIS F. S.; FONTANA, NATALIA A.; OLIVEIRA, CAROLINA G.; FREIRE, MARJORIE C. L. C.; LOPES, JOSE L. S.; MELO, FERNANDO A.; COSTA-FILHO, ANTONIO J.. The GRASP domain in golgi reassembly and stacking proteins: differences and similarities between lower and higher Eukaryotes. FEBS Journal, v. 286, n. 17, p. 3340-3358, . Web of Science Citations: 2. (16/23863-2, 12/20367-3, 09/53989-4, 17/24669-8, 15/50366-7)

MENDES, LUIS FELIPE S.; BATISTA, MARIANA R. B.; JUDGE, PETER J.; WATTS, ANTHONY; REDFIELD, CHRISTINA; COSTA-FILHO, ANTONIO J.. Conformational flexibility of GRASPs and their constituent PDZ subdomains reveals structural basis of their promiscuous interactome. FEBS Journal, . Web of Science Citations: 0. (12/20367-3, 15/50366-7, 16/09676-5, 17/24669-8)

BASSO, LUIS G. M.; RODRIGUES, RENATA Z.; NAAL, ROSE M. Z. G.; COSTA-FILHO, ANTONIO J.. Effects of the antimalarial drug primaquine on the dynamic structure of lipid model membranes. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1808, n. 1, p. 55-64, . Web of Science Citations: 24. (08/57910-0)

MENDES, LUIS F. S.; GARCIA, ASSUERO F.; KUMAGAI, PATRICIA S.; DE MORAIS, FABIO R.; MELO, FERNANDO A.; KMETZSCH, LIVIA; VAINSTEIN, MARILENE H.; RODRIGUES, MARCIO L.; COSTA-FILHO, ANTONIO J.. New structural insights into Golgi Reassembly and Stacking Protein (GRASP) in solution. SCIENTIFIC REPORTS, v. 6, . Web of Science Citations: 6. (12/13309-7, 12/20367-3)

ALVAREZ, NATALIA; MENDES, LUIS F. S.; GABRIELA KRAMER, M.; TORRE, MARIA H.; COSTA-FILHO, ANTONIO J.; ELLENA, JAVIER; FACCHIN, GIANELLA. Development of copper(II)-diimine-iminodiacetate mixed ligand complexes as potential antitumor agents. Inorganica Chimica Acta, v. 483, p. 61-70, . Web of Science Citations: 11. (12/13309-7, 17/24669-8)

CRUSCA, JR., EDSON; MANSOR BASSO, LUIS GUILHERME; ALTEI, WANESSA FERNANDA; MARCHETTO, REINALDO. Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1860, n. 11, p. 2155-2165, . Web of Science Citations: 2. (14/00206-0, 14/18747-8)

MENDES, LUIS F. S.; BASSO, LUIS G. M.; KUMAGAI, PATRICIA S.; FONSECA-MALDONADO, RAQUEL; COSTA-FILHO, ANTONIO J.. Disorder-to-order transitions in the molten globule-like Golgi Reassembly and Stacking Protein. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1862, n. 4, p. 855-865, . Web of Science Citations: 4. (12/13309-7, 14/00206-0, 15/18390-5, 11/21767-2, 12/20367-3, 15/50366-7)

VICENTE, EDUARDO F.; SAHU, INDRA D.; CRUSCA, JR., EDSON; BASSO, LUIS G. M.; MUNTE, CLAUDIA E.; COSTA-FILHO, ANTONIO J.; LORIGAN, GARY A.; CILLI, EDUARDO M.. HsDHODH Microdomain-Membrane Interactions Influenced by the Lipid Composition. Journal of Physical Chemistry B, v. 121, n. 49, p. 11085-11095, . Web of Science Citations: 1. (14/00206-0, 10/06526-6, 15/18390-5, 10/12953-4)

FONSECA-MALDONADO, RAQUEL; MELEIRO, LUANA P.; MENDES, LUIS F. S.; ALVES, LUANA F.; CARLI, SIBELI; MORERO, LUCAS D.; BASSO, LUIS G. M.; COSTA-FILHO, ANTONIO J.; WARD, RICHARD J.. Lignocellulose binding of a Cel5A-RtCBM11 chimera with enhanced beta-glucanase activity monitored by electron paramagnetic resonance. BIOTECHNOLOGY FOR BIOFUELS, v. 10, . Web of Science Citations: 4. (10/18850-2, 15/18149-6, 15/18390-5, 14/50884-5)

FONTANA, N. A.; FONSECA-MALDONADO, R.; MENDES, L. F. S.; MELEIRO, L. P.; COSTA-FILHO, A. J.. The yeast GRASP Grh1 displays a high polypeptide backbone mobility along with an amyloidogenic behavior. SCIENTIFIC REPORTS, v. 8, . Web of Science Citations: 3. (12/13309-7, 16/23863-2, 16/09676-5, 15/18390-5, 15/50366-7, 12/20367-3)

DE PADUA, RICARDO A. P.; KIA, ALI MARTIN; COSTA-FILHO, ANTONIO J.; WILKINSON, SHANE R.; NONATO, M. CRISTINA. Characterisation of the fumarate hydratase repertoire in Trypanosoma cruzi. International Journal of Biological Macromolecules, v. 102, p. 42-51, . Web of Science Citations: 4. (08/08262-6, 08/11644-8, 15/18390-5)

MICHELETTO, MARIANA C.; MENDES, LUIS F. S.; BASSO, LUIS G. M.; FONSECA-MALDONADO, RAQUEL G.; COSTA-FILHO, ANTONIO J.. Lipid membranes and acyl-CoA esters promote opposing effects on acyl-CoA binding protein structure and stability. International Journal of Biological Macromolecules, v. 102, p. 284-293, . Web of Science Citations: 2. (12/13309-7, 14/00206-0, 15/18390-5, 15/50366-7)

BARROSO, RAFAEL P.; BERLIM, LEONARDO S.; ITO, AMANDO S.; COSTA-FILHO, ANTONIO J.. In vitro antioxidant properties of golden grass (Syngonanthus nitens) by electron paramagnetic resonance. FOOD SCIENCE & NUTRITION, v. 7, n. 4, p. 1353-1360, . Web of Science Citations: 0. (15/18390-5)

THIRUPATHI REDDY, S.; SANTOS MENDES, LUIS FELIPE; FONTANA, NATALIA APARECIDA; COSTA-FILHO, ANTONIO JOSE. Exploring structural aspects of the human Golgi matrix protein GRASP55 in solution. International Journal of Biological Macromolecules, v. 135, p. 481-489, . Web of Science Citations: 0. (16/23863-2, 17/12146-0, 17/24669-8, 15/16812-0, 15/50366-7, 12/20367-3)

BATISTA, MARIANA R. B.; WATTS, ANTHONY; COSTA-FILHO, ANTONIO JOSE. Exploring Conformational Transitions and Free-Energy Profiles of Proton-Coupled Oligopeptide Transporters. JOURNAL OF CHEMICAL THEORY AND COMPUTATION, v. 15, n. 11, p. 6433-6443, . Web of Science Citations: 0. (16/16328-3, 15/50366-7)

VIEIRA, ERNANNI D.; BASSO, LUIS G. M.; COSTA-FILHO, ANTONIO J.. Non-linear van't Hoff behavior in pulmonary surfactant model membranes. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1859, n. 6, p. 1133-1143, . Web of Science Citations: 3. (10/17662-8, 14/00206-0, 15/18390-5)

GARCIA, A. F.; SIMAO, A. M. S.; BOLEAN, M.; HOYLAERTS, M. F.; MILLAN, J. L.; CIANCAGLINI, P.; COSTA-FILHO, A. J.. Effects of GPI-anchored TNAP on the dynamic structure of model membranes. Physical Chemistry Chemical Physics, v. 17, n. 39, p. 26295-26301, . Web of Science Citations: 3. (14/00371-1, 10/17662-8, 14/11941-3, 13/26088-1)

BARROSO, RAFAEL P.; BASSO, LUIS G. M.; COSTA-FILHO, ANTONIO J.. Interactions of the antimalarial amodiaquine with lipid model membranes. Chemistry and Physics of Lipids, v. 186, p. 68-78, . Web of Science Citations: 5. (10/17662-8, 12/20367-3)

VICENTE, EDUARDO F.; BASSO, LUIS GUILHERME M.; CESPEDES, GRAZIELY F.; LORENZON, ESTEBAN N.; CASTRO, MARIANA S.; MENDES-GIANNINI, MARIA JOSE S.; JOSE COSTA-FILHO, ANTONIO; CILLI, EDUARDO M.. Dynamics and Conformational Studies of TOAC Spin Labeled Analogues of Ctx(Ile(21))-Ha Peptide from Hypsiboas albopunctatus. PLoS One, v. 8, n. 4, . Web of Science Citations: 13. (10/17662-8, 09/10997-7, 10/06526-6)

DYSZY, FABIO; PINTO, ANDRESSA P. A.; ARAUJO, ANA P. U.; COSTA-FILHO, ANTONIO J.. Probing the Interaction of Brain Fatty Acid Binding Protein (B-FABP) with Model Membranes. PLoS One, v. 8, n. 3, . Web of Science Citations: 6. (10/17662-8, 09/15810-2)

FELICIANO, PATRICIA R.; GUPTA, SHREEDHARA; DYSZY, FABIO; DIAS-BARUFFI, MARCELO; COSTA-FILHO, ANTONIO J.; MICHELS, PAUL A. M.; NONATO, M. CRISTINA. Fumarate hydratase isoforms of Leishmania major: Subcellular localization, structural and kinetic properties. International Journal of Biological Macromolecules, v. 51, n. 1-2, p. 25-31, . Web of Science Citations: 14. (08/08262-6, 06/05538-5, 09/15810-2, 09/10454-3)

VICENTE, EDUARDO F.; BASSO, LUIS GUILHERME M.; CESPEDES, GRAZIELY F.; LORENZON, ESTEBAN N.; CASTRO, MARIANA S.; MENDES-GIANNINI, MARIA JOSE S.; JOSE COSTA-FILHO, ANTONIO; CILLI, EDUARDO M.. Dynamics and Conformational Studies of TOAC Spin Labeled Analogues of Ctx(Ile(21))-Ha Peptide from Hypsiboas albopunctatus. PLoS One, v. 8, n. 4, . Web of Science Citations: 13. (10/17662-8, 09/10997-7, 10/06526-6)

DYSZY, FABIO; PINTO, ANDRESSA P. A.; ARAUJO, ANA P. U.; COSTA-FILHO, ANTONIO J.. Probing the Interaction of Brain Fatty Acid Binding Protein (B-FABP) with Model Membranes. PLoS One, v. 8, n. 3, . Web of Science Citations: 6. (10/17662-8, 09/15810-2)

GARCIA, ASSUERO F.; LOPES, JOSE L. S.; COSTA-FILHO, ANTONIO J.; WALLACE, BONNIE A.; ARAUJO, ANA P. U.. Membrane Interactions of S100A12 (Calgranulin C). PLoS One, v. 8, n. 12, . Web of Science Citations: 3. (10/17662-8, 12/20367-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FILHO, Antonio José da Costa. Estudos da enzima clorocatecol 1,2-dioxigenase por EPR convencional e da estrutura dinâmica de biomembranas por EPR pulsada bidimensional. 2001. Tese (Doutorado) – Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

FILHO, Antonio José da Costa. Interações magnéticas em sais de (cobre-dipeptídeos): Cu2+: Gly-Trp e Cu2+: Trp-Gly. 1997. Dissertação (Mestrado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

KUMAGAI, Patricia Suemy. Interações moleculares no mecanismo de ação da galectina-4 humana. 2016. Tese (Doutorado) – Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

BASSO, Luís Guilherme Mansor. Interações com membranas de peptídeos de fusão da glicoproteína S do SARS-CoV. 2014. Tese (Doutorado) – Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

BASSO, Luís Guilherme Mansor. Interações de fármacos anti-malária com modelos de membrana. 2009. Dissertação (Mestrado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

CARVALHO, Sheila Gonçalves Do Couto. Estudos estruturais e funcionais de diidroorotato desidrogenases. 2008. Tese (Doutorado) – Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

MENDES, Luis Felipe Santos. Caracterização estrutural e dinâmica da proteína de estruturação e compactação do complexo de Golgi (GRASP) em solução. 2018. Tese (Doutorado) – Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto.

FREDDI, Priscilla. Interações entre complexos de interesse farmacológico e modelos de membrana. 2013. Dissertação (Mestrado) - Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto.

CITADINI, Ana Paula da Silva. Estudos da dinâmica estrutural da proteína ligante de cálcio S100A12 humana e da lisozima T4. 2011. Tese (Doutorado) – Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

MESQUITA, Nathalya Cristina de Moraes Roso. Estudos da correlação estrutura-função da enzima Clorocatecol 1,2-Dioxigenase de Pseudomonas putida. 2012. Dissertação (Mestrado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos.

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