CV Lattes
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Sociedade Brasileira de Biofísica (SBBf) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Antonio José da Costa Filho received a Bachelor degree in Physics from the University of São Paulo (USP) in 1994. After that he started his Graduate program in the same university, concluding his Masters in 1996. His PhD project was developed both in São Carlos, under the supervision of Prof. Otaciro Nascimento, and in Ithaca (USA), where he spent 3 years as a visiting graduate student at Cornell University, working under Prof. Jack Freed´s supervision. During his PhD, Prof. Antonio Costa worked on the development of new electron magnetic resonance methods for the study of: (1) lipid-protein interactions, (2) the dynamic structure of lipid membranes, and (3) metal centers in protein structure. In 2001 he received his PhD degree in Physics from the University of São Paulo and started working as an Assistant Professor at USP (Campus São Carlos). He is currently Full Professor at USP-Ribeirão Preto and his research interests involve the investigation of interactions between biomolecules with emphasis on how the interaction between proteins and their ligands (substrates, inhibitors, and membranes) can lead to modulation of the protein function. More recently, he also got interested in the structural behavior of proteins involved in the unconventional secretory pathways of the cell, in particular the so-called Golgi Reassembly and Stacking Proteins (GRASPs). To accomplish those objectives his group makes use of a combined and interdisciplinary approach of experimental techniques, such as magnetic resonance, circular dichroism, and microcalorimetry. He has received several awards for his teaching skills as well as for contributions to his specific field of scientific interest. He is a Young Affiliate Alumnus of the Brazilian Academy of Sciences and of the World Academy of Sciences, former member and coordinator of the Advisory Committee of the Brazilian National Science Foundation (CNPq) on Biophysics/Biochemistry/Physiology/Pharmacology/Neurosciences, current President of the Brazilian Biophysical Society, and director of the Ribeirão Preto Institute for Advanced Studies of the University of São Paulo. (Source: Lattes Curriculum)
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The emergence of life diversity and complexity has been facilitated by intercellular communication, which is partially supported by a highly conserved pathway known as the conventional secretory pathway. This pathway involves the secretion of proteins containing a signal peptide through the endoplasmic reticulum-Golgi apparatus-final destination route. Although some questions remain open,…
Low complexity domains (LCDs) are sequences of amino acids with very peculiar structural features and still poorly explored in Biochemistry and Molecular Biophysics. Their dynamics of interactions as well as their functions, toxicity and persistence during evolution still lack better understanding. It is known, tough, that if used as molecular adhesives in proteins (so called- chimeras), …
(Only some records are available in English at this moment)
Liquid-liquid phase separation (LLPS) is a well-known phenomenon in areas such as polymer physical chemistry, materials science, and engineering. In LLPS, a thermodynamically favorable phase separation gives rise to liquid droplets rich in a solute (dense phase) that become dispersed in a dilute liquid phase. In Cell Biology, LLPS has received recent attention after the demonstration of i…
GRASPs, a family of peripheral membrane-associated proteins, were initially recognized as essential factors in the reassembly of Golgi cisternae after mitotic events. More recently, their involvement in unconventional protein secretion (UPS) pathways has emerged as a more significant aspect than their role as Golgi structural factors. UPS has garnered considerable attention due to its cru…
The Golgi Reassembly And Stacking Proteins (GRASPs) are involved in a series of functions, both in unconventional secretion mechanisms and in the structuration and organization of the Golgi apparatus. However, understanding their exact role in each situation still needs more structural and functional results at the molecular level. In performing such functions, GRASPs always seem to be so…
(Only some records are available in English at this moment)
Intercellular communication, facilitated by the conventional secretory pathway, has played apivotal role in the evolution of life's diversity and complexity. This pathway, involving the secretion of proteins containing signal peptides, has long been understood, although recentdiscoveries have challenged the idea of a single secretory route. Unconventional protein secretion(UPS) has emerge…
The discovery and development of phototoxic proteins able to produce reactive oxygen species allowed the employment of genetically encoded photosensitizers (PS) as light activated devices. Light-induced generation of reactive oxygen species by chromogenic compounds has been used for single molecule inactivation and cell killing. MiniSOG is a small, soluble, flavin-binding protein with hig…
Eukaryotic cells have a complex and regulated secretory system that can deal with up to 30% of the total proteome. A subfamily of the Golgi matrix proteins called Golgi Reassembly and Stacking Proteins (GRASP), which are critical players in the unconventional, stress-induced, secretory pathway (UPS), was also shown to be fundamental for the Golgi dynamics during mitosis/apoptosis and Golg…
Alkaline phosphatases are a class of enzymes that catalyze the hydrolysis of phosphomonoesters, thus producing phosphate. In humans, four alkaline phosphatases have been identified so far. In mammals, this enzyme can be associated to genetic disorders leading to different levels of bone failure and pathological blood vessel mineralization. Due to its biological relevance, tissue non-speci…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 14 / 10 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 41 / 31 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 8 / 8 | Completed scholarships abroad |
| 67 / 53 | All research grants and scholarships |
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