Abstract
The Na+/H+ exchanger isoform 3 (NHE3) is a transport protein responsible for reabsorption of the majority of the filtered NaCl, NaHCO3 and, consequently, water, in renal proximal tubules. This transporter therefore plays an essential role regulating volume and acid-base homeostasis and determining blood pressure levels. The NHE3 activity modulation in response to stimuli is mediated by a …