CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas Bacharelado from Universidade Estadual de Ponta Grossa (2007), master's at Microbiology from Universidade de São Paulo (2011) and doctorate at TOXINOLOGIA from Instituto Butantan (2015). Has experience in Microbiology, focusing on Microbiology, acting on the following subjects: escherichia coli, ehec, controle biológico, epec and endofíticos. (Source: Lattes Curriculum)
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Recently, the Antibody Development Center at the Butantan Institute began implementing the Center of Nanobody Discovery, led by researchers Daniela Luz, Debora Moretti and Roxane Piazza. This center aims to implement a platform for the selection of therapeutic nanobodies and detection against different antigens, from poisons to infectious and tumor targets with the purpose of generating m…
Despite significant advances in research, cancer still poses a threat to global health. This disease chronicity and constant antigenic stimulation leads to the differentiation of CD8+ T cells into populations with altered effector functions, a unique epigenetic profile, and high levels of expression of multiple inhibitory receptors. These negative regulatory receptors have the function of…
Antibodies are glycoproteins produced by plasma cells, the IgG the most commonly used in antibody therapy. Hybridoma technology has enabled the production of monoclonal antibodies (mAbs) derived from laboratory animals. Methods as phage display allowed the development of recombinant antibody fragments (rAbs), with in vitro immunological repertoires without direct immunization of living ho…
Shiga toxins (Stx) produced by Shiga toxin-producing Escherichia coli (STEC) are the most potent cytotoxins of type AB5, found as two distinct types (Stx1 and Stx2) and subtypes, causing hemolytic uremic syndrome (HUS), characterized by thrombocytopenia, hemolytic anemia, and renal failure, which can cause death. The most indicated treatment against Stx-mediated HUS is the neutralization …
Despite significant advances in research, cancer still represents a threat to global health. The chronicity of this disease and constant antigenic stimulation leads to the differentiation of CD8+ T cells into populations with altered effector functions, a unique epigenetic profile, and high levels of expression of multiple inhibitory receptors. Such negative regulatory receptors have the …
Dengue is a neglected viral disease that infects and kills thousands of people each year. In areas where arboviruses co-circulate, the differential diagnosis of the disease is challenging due to the possibility of serum antibody cross-reactivity to other flaviviruses. This scenario is exacerbated by the lack of safe and effective vaccines widely available to the general population. It is …
(Only some records are available in English at this moment)
Rheumatoid arthritis (RA) is characterized by chronic infiltration of immune cells into the synovial membrane, leading to progressive destruction of articular cartilage and bone. The most notable success in treating rheumatoid arthritis has been the introduction of Tumor Necrosis Factor (TNF) inhibitors. Anti-TNF agents have radically changed the prognosis of many patients with RA, provid…
Diarrheal disease is one of the main public health problems worldwide, causing about 1.5 million deaths annually in children under five years of age, and about 30 to 40% of episodes of acute diarrhea in the world are caused by diarrheagenic Escherichia coli, with emphasis on the pathotype responsible for acute diarrhea/traveller's diarrhea, enterotoxigenic E. coli (ETEC). ETEC produces th…
Immune checkpoints are negative regulatory receptors expressed on immune cells. Under normal physiological conditions, its function is to act as a brake on the immune system, maintaining self-tolerance and preventing immunopathologies. However, these molecules also participate in immune escape mechanisms, causing dysfunction in T cell populations in a variety of diseases, including cancer…
(Only some records are available in English at this moment)
This research focuses on immune checkpoints, crucial regulators of T lymphocyte activity. Immune checkpoint discovery began in the 1990s with proteins like PD-1 and CTLA-4. TIM-3 is also a checkpoint associated with tumor and virus evasion and its blockade by monoclonal antibodies has proved capable of being used as a target for anti-tumor therapies. Immunotherapy, utilizing monoclonal an…
Shiga toxin-producing Escherichia coli is responsible for hemorrhagic colitis and hemolytic-uremic syndrome, which aggravates the condition of the infected patients. The diagnosis of this pathogen is not included in routine laboratories in developing countries. The development of tools for detecting these toxins becomes very relevant to their diagnosis. Antibodies have proven to be an exc…
| 3 / 3 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 7 / 6 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 17 / 16 | All research grants and scholarships |
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