CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Since my undergraduate training at the medical school, I started to research the cardiovascular system in the Dr Vassallo Lab (UFES-Brazil). My interest in vascular function and dysfunction on cardiovascular diseases took me to develop my graduate training in the laboratory of Dr Vassallo and Dr Jesus Marín and Mercedes Salaices (UAM-Spain) studying the role of ouabain on the vascular reactivity adjustments observed in hypertension. I have been PI of my own laboratory since 2002, on the Physiology and Biophysics Department, Biomedical Science Institute at the University of Sao Paulo Brazil. During all this time, graduate and undergraduate students have been participating to the Lab. My group have won fellowships, travel and presentation awards, and we consistently received financial support to develop our research (FAPESP, CNPq). The main aim of the Vascular Physiology Lab is to understand the molecular pathways involved on functional and structural adjustments in conductance and resistance vessels of cardiovascular diseases (hypertension and heart failure), and as pharmacological and non-pharmacological (exercise training, microbiota and cross-fostering) maneuvers can restore or prevent these alterations. https://orcid.org/0000-0002-0944-9483 (Source: Lattes Curriculum)
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Renovascular hypertension is the main cause of secondary hypertension, which correlates with obstruction of the renal arteries and progressive reduction in renal perfusion, leading to chronic and sustained activation of the renin-angiotensin-aldosterone system. Aldosterone is considered an important therapeutic target in hypertension, and its effects are mediated by the activation of the …
Renovascular hypertension is the main cause of secondary and treatment-resistant hypertension, which correlates with an obstruction of the renal arteries and progressive reduction of renal perfusion, leading to chronic and sustained activation of the renin-angiotensin-aldosterone system. Aldosterone is considered an important therapeutic target in hypertension and its effects are mediated…
Hypertension, the multifactorial disease, characterized by high blood pressure (BP) levels, is the most common chronic disease in the Brazilian people. Among the mechanisms involved in the pathogenesis of this disease, the increment in plasma levels of Na+/ K+ ATPase inhibitors, such as ouabain (OUA), is observed. Higher sodium concentration associated with volume expansion, increase OUA …
Myocardial infarction (MI) is an ischemic disease that occurs by a deficient perfusion of cardiac tissue, resulting in necrosis of the myocardial wall. Despite the reduction in the number of death due to MI, this disease still has a high incidence and many patients have consequences such as low physical capacity. Among alterations found in IM the endothelial dysfunction is present, it is …
(Only some records are available in English at this moment)
Renovascular hypertension is the main cause of secondary hypertension, which correlates with obstruction of the renal arteries and progressive reduction in renal perfusion, leading to chronic and sustained activation of the renin-angiotensin-aldosterone system. Aldosterone is considered an important therapeutic target in hypertension, and its effects are mediated by the activation of the …
Renovascular Hypertension is the main cause of secondary and treatment-resistant Hypertension, which correlates with an obstruction of the renal arteries and progressive reduction of renal perfusion, leading to chronic and sustained activation of the renin-angiotensin-aldosterone system. Aldosterone is considered an important therapeutic target in Hypertension and its effects are mediated…
After 1991, with the discoveries of the essential role of the perivascular adipose tissue (PVAT) in the regulation of vascular tone, it has become an important target of studies that aim to understand its functioning under physiological and pathological conditions. Known for its anticontractile effect, PVAT modulates the degree of contraction of vascular smooth muscle cells through the re…
Ouabain (Oua) is a glycoside cardenolide, found in the plant kingdom and mammals. In addition to inhibiting the activity of Na+-K+-ATPase (NKA), this interaction is capable of regulating protein kinases through its signalosome activity, causing cellular effects such as hypertrophy and generation of reactive oxygen species (ROS). Elevated levels of this glycoside are associated with severa…
Since the XX century researchers classified Hypertension as a multifactorial disease, that could be affected by environmental factors. Studies developed during the 80s suggest that features from the postnatal environment have an effect on Hypertension development, showing that rats from hypertensive strains fostered to normotensive mothers - in an experimental approach termed cross-foster…
(Only some records are available in English at this moment)
In cardiometabolic diseases, such as arterial hypertension, it has been shown that the perivascular adipose tissue (PVAT) is dysfunctional with loss of its anticontractile effect. It has already been demonstrated, in spontaneously hypertensive rats (SHR) , an association between the thoracic aorta PVAT's dysfunction and reduced levels of vasodilator mediators, adipose tissue whitening, an…
| 2 / 2 | Ongoing grants |
| 11 / 8 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 21 / 13 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 37 / 26 | All research grants and scholarships |
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