CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Since my undergraduate training at the medical school, I started to research the cardiovascular system in the Dr Vassallo Lab (UFES-Brazil). My interest in vascular function and dysfunction on cardiovascular diseases took me to develop my graduate training in the laboratory of Dr Vassallo and Dr Jesus Marín and Mercedes Salaices (UAM-Spain) studying the role of ouabain on the vascular reactivity adjustments observed in hypertension. I have been PI of my own laboratory since 2002, on the Physiology and Biophysics Department, Biomedical Science Institute at the University of Sao Paulo Brazil. During all this time, graduate and undergraduate students have been participating to the Lab. My group have won fellowships, travel and presentation awards, and we consistently received financial support to develop our research (FAPESP, CNPq). The main aim of the Vascular Physiology Lab is to understand the molecular pathways involved on functional and structural adjustments in conductance and resistance vessels of cardiovascular diseases (hypertension and heart failure), and as pharmacological and non-pharmacological (exercise training, microbiota and cross-fostering) maneuvers can restore or prevent these alterations. (Source: Lattes Curriculum)
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Hypertension, the multifactorial disease, characterized by high blood pressure (BP) levels, is the most common chronic disease in the Brazilian people. Among the mechanisms involved in the pathogenesis of this disease, the increment in plasma levels of Na+/ K+ ATPase inhibitors, such as ouabain (OUA), is observed. Higher sodium concentration associated with volume expansion, increase OUA …
Myocardial infarction (MI) is an ischemic disease that occurs by a deficient perfusion of cardiac tissue, resulting in necrosis of the myocardial wall. Despite the reduction in the number of death due to MI, this disease still has a high incidence and many patients have consequences such as low physical capacity. Among alterations found in IM the endothelial dysfunction is present, it is …
Acute myocardial infarction (MI) accounts for 23% of mortality due to cardiovascular diseases in the world. MI survivors usually show symptoms of heart failure (HF), associated with a significant reduction in life expectancy after a heart attack. In addition to changes in heart tissue, the authors observed an increase in peripheral vascular resistance due to activation of neurohumoral sys…
Hypertension is a cardiovascular disease characterized by increased peripheral vascular resistance, in which the resistance arteries and activation of the sympathetic nervous system play an important role. From the 80's, has been shown that hypertension coexists with increased plasma levels of a factor that inhibits the Na+K+-ATPase, both in humans and in experimental animal models (e.g. …
(Only some records are available in English at this moment)
Renovascular hypertension is the main cause of secondary and treatment-resistant hypertension, which correlates with an obstruction of the renal arteries and progressive reduction of renal perfusion, leading to chronic and sustained activation of the renin-angiotensin-aldosterone system. Aldosterone is considered an important therapeutic target in hypertension and its effects are mediated…
Since the XX century researchers classified hypertension as a multifactorial disease, that could be affected by environmental factors. Studies developed during the 80s suggest that features from the postnatal environment have an effect on hypertension development, showing that rats from hypertensive strains fostered to normotensive mothers - in an experimental approach termed cross-foster…
For a long time considered only a mechanical protection of blood vessels and adjacent tissues, perivascular adipose tissue (PVAT) has received increasing attention due to research's describing its paracrine role in physiological conditions, involving the release of vasoactive factors, such as adipokines, nitric oxide (NO) and hydrogen sulfide, and their anti-contractile effect. However, P…
Hypertension is a disease characterized by a chronic increase in arterial, systolic and/or diastolic, blood pressure (BP), being a major risk factor for other cardiovascular, cerebrovascular and renal diseases. It has become one of the major public health concerns nowadays due to its high morbidity and mortality. Several hypertension risk factors have already been described, such as overw…
Hypertension is considered a huge public health problem for its high prevalence, lower control rates and for being an important risk factor for other cardiovascular diseases. It is characterized for high arterial systolic and/ or diastolic pressures, as well as metabolic adjustments associated to functional and/or structural alterations in essential organs like: heart, brain, kidneys and …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 9 / 6 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 18 / 10 | Completed scholarships in Brazil |
| 30 / 19 | All research grants and scholarships |
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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 8 |
| Citations | 91 |
| Cit./Article | 11.4 |
| Data from Web of Science | |
FONTES, MILENE TAVARES; PAULA, SULIANA MESQUITA; LINO, CAROLINE ANTUNES; SENGER, NATHALIA; COUTO, GISELE KRUGER; DE MORAIS BARRETO-CHAVES, MARIA LUIZA; MILL, JOSE GERALDO; ROSSONI, LUCIANA VENTURINI. Renin-angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure. Clinical Science, v. 134, n. 23, p. 3195-3211, DEC 2020. Web of Science Citations: 0. (16/08907-3, 14/20303-0)
FELIZARDO, R. J. F.; WATANABE, I. K. M.; DARDI, PATRIZIA; ROSSONI, L. V.; CAMARA, N. O. S.. The interplay among gut microbiota, hypertension and kidney diseases: The role of short-chain fatty acids. PHARMACOLOGICAL RESEARCH, v. 141, p. 366-377, MAR 2019. Web of Science Citations: 4. (16/08907-3, 17/06222-6, 17/05264-7, 12/02270-2, 12/15205-4)
VICTORIO, JAMAIRA A.; FONTES, MILENE T.; ROSSONI, LUCIANA V.; DAVEL, ANA P.. Different Anti-Contractile Function and Nitric Oxide Production of Thoracic and Abdominal Perivascular Adipose Tissues. FRONTIERS IN PHYSIOLOGY, v. 7, JUL 12 2016. Web of Science Citations: 18. (14/07947-6, 14/20303-0)
ANDROWIKI, ALINE C. D.; CAMARGO, LIVIA DE LUCCA; SARTORETTO, SIMONE; COUTO, GISELE K.; RIBEIRO, IZABELA M. R.; VERISSIMO-FILHO, SIDNEY; ROSSONI, LUCIANA V.; LOPES, LUCIA R.. Protein disulfide isomerase expression increases in resistance arteries during hypertension development. Effects on Nox1 NADPH oxidase signaling. FRONTIERS IN CHEMISTRY, v. 3, MAR 27 2015. Web of Science Citations: 10. (10/18380-6, 13/03520-5, 13/07937-8)
COUTO, GISELE K.; BRITT, LUIZ ROBERTO G.; MILL, JOSE G.; ROSSONI, LUCIANA V.. Enhanced nitric oxide bioavailability in coronary arteries prevents the onset of heart failure in rats with myocardial infarction. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, v. 86, p. 110-120, SEP 2015. Web of Science Citations: 15. (10/50048-1)
GIRARDI, ADRIANA CASTELLO COSTA; FUKUDA, LÍVIA EMY; ROSSONI, LUCIANA VENTURINI; MALNIC, GERHARD; REBOUÇAS, NANCY AMARAL. Dipeptidyl peptidase IV inhibition downregulates Na+-H+ exchanger NHE3 in rat renal proximal tubule. American Journal of Physiology : Renal Physiology, v. 294, n. 2, p. F414-F422, Feb. 2008. (04/01683-5)
BLANCO-RIVERO, JAVIER; COUTO, GISELE K.; PAULA, SULIANA M.; FONTES, MILENE T.; ROSSONI, V, LUCIANA. Enhanced sympathetic neurotransduction in the superior mesenteric artery in a rat model of heart failure: role of noradrenaline and ATP. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 320, n. 2, p. H563-H574, FEB 2021. Web of Science Citations: 0. (10/50048-1, 14/20303-0, 14/22335-7)
DAVEL, ANA P.; VICTORIO, JAMAIRA A.; DELBIN, MARIA A.; FUKUDA, LIVIA E.; ROSSONI, LUCIANA V.. Enhanced endothelium-dependent relaxation of rat pulmonary artery following beta-adrenergic overstimulation: Involvement of the NO/cGMP/VASP pathway. Life Sciences, v. 125, p. 49-56, MAR 15 2015. Web of Science Citations: 7. (11/15972-2)
DAVEL, A. P.; CERAVOLO, G. S.; WENCESLAU, C. F.; CARVALHO, M. H. C.; BRUM, P. C.; ROSSONI, L. V.. Increased Vascular Contractility and Oxidative Stress in beta(2)-Adrenoceptor Knockout Mice: The Role of NADPH Oxidase. JOURNAL OF VASCULAR RESEARCH, v. 49, n. 4, p. 342-352, 2012. Web of Science Citations: 17.
WENCESLAU, CAMILLA F.; ROSSONI, LUCIANA V.. Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+K+-ATPase/cSRC pathway. Journal of Hypertension, v. 32, n. 3, p. 542-554, MAR 2014. Web of Science Citations: 19. (10/18380-6)
DE OLIVEIRA, HELANE TITO; COUTO, GISELE KRUGER; DAVEL, ANA PAULA; XAVIER, FABIANO ELIAS; ROSSONI, LUCIANA VENTURINI. Chronic cyclooxygenase-2 inhibition prevents the worsening of hypertension and endothelial dysfunction induced by ouabain in resistance arteries of spontaneously hypertensive rats. VASCULAR PHARMACOLOGY, v. 139, AUG 2021. Web of Science Citations: 0. (10/18380-6)
(References retrieved automatically from State of São Paulo Research Institutions)
COUTO, Gisele Kruger. Avaliação temporal da função vascular em aorta de camundongos com deleção dos receptores <font face=\"symbol\">a2A e <font face=\"symbol\">a2BC adrenérgicos.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (05/52505-2)
COUTO, Gisele Kruger. Estudo da função em artérias de resistência de ratos pós-infarto do miocárdio.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (07/55030-0)
NETO, Aldair de França. Estudo dos mecanismos envolvidos no remodelamento de artérias de resistência de ratos hipertensos induzidos pelo tratamento com ouabaína.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (12/00217-7)
FONTES, Milene Tavares. Avaliação da influência do tecido adiposo perivascular (PVAT) na reatividade vascular da aorta de ratos com insuficiência cardíaca submetidos ao treinamento físico aeróbio e resistido.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (14/20303-0)
WENCESLAU, Camilla Ferreira. Efeito da administração crônica a longo prazo de ouabaína sobre a pressão arterial e a reatividade vascular de artérias mesentéricas de resistência de rato: possíveis mecanismos envolvidos.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (05/56271-6)
OLIVEIRA, Angelo Bernak de. Avaliação dos mecanismos envolvidos na vasodilatação dependente do endotélio em aorta de camundongos tratados com isoproterenol.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/16017-4)