graduate at Chemistry from Universidade Estadual de Campinas (1995), master's at Chemistry from Universidade Estadual de Campinas (1996) and ph.d. at Chemistry from Universidade Estadual de Campinas (2000). Has experience in Chemistry, acting on the following subjects: espectrometria de massas, reatividade, proteína, cálculos ab initio and auto-organização. (Source: Lattes Curriculum)
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The study of protein interactions is an important field to understand protein functions. This is, however, one area of great experimental difficulties due to inherent complexity of proteins and peptides. High resolution structural tools (i.e. X-Ray diffraction and Nuclear Magnetic Resonance are the de facto methods for these studies. However, most proteins and protein complexes are not am…
The study of protein interactions is an important field to understand protein functions. This is, however, one area of great experimental difficulties due to inherent complexity of proteins and peptides. High resolution structural tools (i.e. X-Ray diffraction and Nuclear Magnetic Ressonance are the de facto methods for these studies. However, most proteins and protein complexes are not a…
(Only some records are available in English at this moment)
The structure determination of proteins and their interactions with other proteins are key informations in the elucidation of the mechanism of action of these macromolecules. The combinationof cross-linking with Mass Spectrometry (MS) is a strategy that allows the structural characterization of proteins and protein complexes, especially when high resolution techniques cannot be employed. …
The use of experimental mass spectrometric (MS) data in protein structure characterization is a very attractive approach due to the intrinsic characteristics of MS, such as high sensitivity, fast analysis, and, most importantly, its universality. Although many protein-protein complexes have been solved by cross-linking/mass spectrometry (XLMS) technique, there is no effective protocol to …
Antibiotic Resistance (AMR) poses a serious threat to public health. Brazilian National Health System (SUS) estimates that about 19,000 Brazilians dies of infections due to AMRs every year. The World Health Organization (WHO) has issued a worldwide warning on this threat and suggested the development of new antibiotics to combat these microorganisms. One approach to this problem is throug…
Proteins constitute the structural factory by which cells perform all the metabolic and regulatory processes. Understand these biological events at the molecular level necessarily requires the description of the structure of these biomolecules at the atomic level. Protein Crystallography (DRX) and Nuclear Magnetic Resonance (NMR) are the well stablished methods for the study of the protei…
(Only some records are available in English at this moment)
Natural occurring proteins mediates several biological functions, from the use of solar energy to manufacture complex molecules and sensitive detection of small molecules (olfactory receptors) and light (rhodopsin) to conversion of pH gradients into chemical bonds (ATP synthase). Interestingly, only a small fraction of protein sequence space has been sampled by nature. Evolution proceeds …
The chemical cross-linking coupled to mass spectrometry (MS) is one of the main techniques for protein and protein complex structural characterization when none of the high resolution techniques can be applied. Our laboratory has specialized and worked successfully on developing and applying this technique in protein and protein complexes in vitro. The next big step for this technique is …
| 1 / 1 | Ongoing research grants |
| 6 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 15 / 10 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 25 / 19 | All research grants and scholarships |
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CV Lattes
ORCID