Andre de Souza Mecawi

• Abstract

  Synchronisation to periodic cues such as food/water availability and light/dark cycles is crucial for homeostasis. Modern lifestyles disturb our diurnal rhythms, most acutely by jetlag, but more insidiously by shift work and exposure to artificial light at night (ALAN), with consequential increased susceptibility of night-time workers to diabetes, obesity, cardiovascular disease and depre…

  Shining light on the functions of a brain non-visual opsin, AP.R SPRINT

• Abstract

  The search for effective, short-acting, and reversible anesthetics has led to the creation of ketamine, widely used in veterinary medicine but with limited clinical application in humans due to its hallucinogenic and dissociative effects, which have popularized it as a recreational drug. Recently, its use in treating treatment-resistant depression has gained attention, demonstrating antid…

  Role of hypothalamic magnocellular neurons in mediating the psychedelic and antidepressant properties of ketamine, AP.R

• Abstract

  Pregnancy is a period of extreme changes in the female's physiology, adapting the mother's organism to ensure healthy development of the embryo/fetus. Preeclampsia (PE) is a disease characteristic of pregnancy and is defined by the development of hypertension in the second half of pregnancy, associated with proteinuria and/or target organ dysfunction. It affects between 3 and 5% of pregna…

  Control of vasopressin secretion in pregnancy and its implications in pathophysiology of Preeclampsia, AP.JP

• Control of Vasopressin Secretion in Pregnancy and its Implications in Pathophysiology of Preeclampsia, BP.TT

• Abstract

  ABSTRACTHypothalamic magnocellular neurons are essential participants in the regulation of hydromineral homeostasis, secreting the neuropeptide arginine-vasopressin (AVP). Such fact occurs due to its ability to be osmosensitive - the release of AVP occurs in response to changes in the body (such as hyperosmolarity caused by intracellular dehydration); these changes lead to cell shrinkage …

  Microtubule Dynamics and the Influence of Fidgetin on Neuronal Osmosensitivity: an exploratory in vitro approach, BP.IC

• Abstract

  Among the hypertensive disorders of pregnancy, pre-eclampsia (PE) is the one most associated with highmorbidity and mortality, as fetal suffering and complications occur in various organs. This fact is observedworldwide and, although it majorly affects women of advanced gestational age, young people in peripheralfinancial conditions are also vulnerable to such complications. Although PE h…

  Electrophysiologic and Molecular impacts of three preeclampsia pre-clinic models on vasopressin-producing magnocellular neurons, BP.PD

(Only some records are available in English at this moment)

• Abstract

  The peptidergic neurons located in the hypothalamus are essential for the survival of vertebrate species, playing an essential role in the regulation of multiple homeostatic functions and behaviors. Those neurons produce and realize several neuropeptides that can work as hormones or neurotransmitters, such as vasopressin, oxytocin, pro-opiomelanocortin, agouti-related protein, and neurope…

  Multispecies single-cell transcriptomic atlas of the hypothalamus: tracking the evolutive pathways taken by the peptidergic neurons, BE.EP.DD