CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Instituto de Saúde e Sociedade (ISS) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor's at Philosophy (2006) and Psychology (1991), Universidade de São Paulo (2006), doctor in Psychobiology (Universidade de São Paulo, 1996) and Philosophy (Universidade Federal de São Carlos, 2010). Associate professor at the Federal University of São Paulo. Current line of research phocus the following subjects: anxiety, animal models, serotonin, GABA, CRF and behavior. Works as a reviewer for different national and international journals. Main researcher and co-responsible for the research group entitled Neurobiology of stress, anxiety and drug addicition at the Federal University of São Paulo. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Deep brain stimulation could be an alternative treatment for anxiety |
The concept of stress is based on the observation that different types of stimuli (endogenous or extern to the subject), that might threaten the organism homeostasis, activate a series of physiological alterations named "general adaptation syndrome". The term stimulus (or stressor) corresponds to the events or circunstances that are perceived as aversive by the subject and that generate…
Studies aimed at the neurobiology of anxiety have, during the last years, dedicated considerable attention to the role played by different neurochemical systems on the modulation of defensive responses to aversive stimuli. In this sense, the important role played by serotonin (5-HT) has been emphasized by the clinical efficacy of serotonergic drugs for the treatment of different anxiety…
The concept of stress is based on the observation that any environmental change, either external or internal, can disturb the maintenance of homeostasis/allostasis, causing a series of physiological alterations, the so-called "general adaptation syndrome". The purpose of the stress reaction is to maintain homeostasis/allostasis, which includes physiological reactions such as endocrine act…
The concept of stress is based on the observation that any environmental change, either external or internal, can disturb the maintenance of homeostasis/allostasis, causing a series of physiological alterations, the so-called "general adaptation syndrome". The purpose of the stress reaction is to maintain homeostasis/allostasis, which includes physiological reactions such as endocrine act…
(Only some records are available in English at this moment)
One of the main neurochemical systems related to anxiety and panic responses is the serotonergic system, arising from the Dorsal Raphe nucleus (DR). Previous evidence suggests that the DR is not homogeneous, but a group of distinct neuronal subpopulations, with morphological and functional differences. The serotonergic (5-HT) neurons of the dorsal region of the dorsal raphe (DRD) seem to …
Previous results obtained using Deep Brain Stimulation (DBS) applied to the dorsal portion of the dorsal raphe nucleus (DDR) and to the lateral wings (alDRN) of the same structure in rats showed anxiolytic-like effects of DRD stimulation and panicolytic-like effects of the stimulation of the alDRN in the elevated T-maze model (ETM). In addition, the DBS technique also increased c-Fos prot…
Crack cocaine was introduced in Brazil in the late 1980s or early 1990s, and its use has dramatically increased in recent decades for all socioeconomic groups. Today, Brazil is also the largest world market for crack cocaine. Crack users have a worse prognosis when compared to users of other illicit drugs because the drug causes a more serious dependency. Drug dependence is a chronic and …
Environmental enrichment (EE) consists of an animal management technique with temporal, physical, social and sensory strategies, aimed at offering a series of incentives that can increase comfort and adaptability, both physiological and psychological, of laboratory animals. The effects of EE can be assessed by exposing animals to different behavioral tests. Among its different application…
(Only some records are available in English at this moment)
One of the main neurochemical systems related to anxiety and panic responses is the serotonergic system, arising from the dorsal raphe nucleus (DR). Previous evidence suggests that the DR is not homogeneous, but a group of distinct neuronal subpopulations, with morphological and functional differences. The dorsal region of the dorsal raphe (DRD) seems to be critically involved with the re…
| 1 / 1 | Ongoing research grants |
| 10 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 15 / 9 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 29 / 16 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 10 |
| Citations | 136 |
| Cit./Article | 13.6 |
| Data from Web of Science | |
SILVA, MARIANA S. C. F.; PEREIRA, BRUNO A.; CESPEDES, ISABEL C.; NASCIMENTO, JULIANA O. G.; BITTENCOURT, JACKSON C.; VIANA, MILENA B.. Dorsomedial hypothalamus CRF type 1 receptors selectively modulate inhibitory avoidance responses in the elevated T-maze. Behavioural Brain Research, v. 271, p. 249-257, SEP 1 2014. Web of Science Citations: 12. (13/17389-8, 11/17471-0)
SILVA, MARIANA S. C. F.; SOUZA, THAISSA M. O.; PEREIRA, BRUNO A.; RIBEIRO, DANIEL A.; CESPEDES, ISABEL C.; BITTENCOURT, JACKSON C.; VIANA, MILENA B.. The blockage of ventromedial hypothalamus CRF type 2 receptors impairs escape responses in the elevated T-maze. Behavioural Brain Research, v. 329, p. 41-50, JUN 30 2017. Web of Science Citations: 3. (13/17389-8)
DE ANDRADE, J. S.; CESPEDES, I. C.; ABRAO, R. O.; DOS SANTOS, T. B.; DINIZ, L.; BRITTO, L. R. G.; SPADARI-BRATFISCH, R. C.; ORTOLANI, D.; MELO-THOMAS, L.; DA SILVAA, R. C. B.; et al. Chronic unpredictable mild stress alters an anxiety-related defensive response, Fos immunoreactivity and hippocampal adult neurogenesis. Behavioural Brain Research, v. 250, p. 81-90, AUG 1 2013. Web of Science Citations: 28. (11/17471-0, 11/01409-4)
M.D. RIBEIRO; G.M. ONUSIC; S.C. POLTRONIERI; M.B. VIANA. Effect of Erythrina velutina and Erythrina mulungu in rats submitted to animal models of anxiety and depression. Brazilian Journal of Medical and Biological Research, v. 39, n. 2, p. 263-270, Fev. 2006.
WSCIEKLICA, TATIANA; SILVA, MARIANA S. C. F.; LEMES, JESSICA A.; MELO-THOMAS, LIANA; CESPEDES, ISABEL C.; VIANA, MILENA B.. Deep brain stimulation of the dorsal raphe inhibits avoidance and escape reactions and activates forebrain regions related to the modulation of anxiety/panic. Behavioural Brain Research, v. 321, p. 193-200, MAR 15 2017. Web of Science Citations: 5. (13/17389-8)
LOPES, DANIELLE A.; LEMES, JESSICA A.; MELO-THOMAS, LIANA; SCHOR, HERBERT; DE ANDRADE, JOSE S.; MACHADO, CARLA M.; HORTA-JUNIOR, JOSE A. C.; CESPEDES, ISABEL C.; VIANA, MILENA B.. Unpredictable chronic mild stress exerts anxiogenic-like effects and activates neurons in the dorsal and caudal region and in the lateral wings of the dorsal raphe nucleus. Behavioural Brain Research, v. 297, p. 180-186, JAN 15 2016. Web of Science Citations: 6. (13/17389-8)
DE ANDRADE, J. S.; ABRAO, R. O.; CESPEDES, I. C.; GARCIA, M. C.; NASCIMENTO, J. O. G.; SPADARI-BRATFISCH, R. C.; MELO, L. L.; DA SILVA, R. C. B.; VIANA, M. B.. Acute restraint differently alters defensive responses and fos immunoreactivity in the rat brain. Behavioural Brain Research, v. 232, n. 1, p. 20-29, JUN 15 2012. Web of Science Citations: 19. (11/17471-0)
DINIZ, L.; DOS REIS, B. B.; DE CASTRO, G. M.; MEDALHA, C. C.; VIANA, M. B.. Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses. Brazilian Journal of Medical and Biological Research, v. 44, n. 10, p. 1048-1053, OCT 2011. Web of Science Citations: 14.
M.D. RIBEIRO; G.M. ONUSIC; S.C. POLTRONIERI; M.B. VIANA. Effect of Erythrina velutina and Erythrina mulungu in rats submitted to animal models of anxiety and depression. Brazilian Journal of Medical and Biological Research, v. 39, n. 2, p. -, Fev. 2006.
DA SILVA, E. S.; POLTRONIERI, S. C.; NASCIMENTO, J. O. G.; ZANGROSSI, JR., H.; VIANAA, M. B.. Facilitation of 5-HT2A/2C-mediated neurotransmission in the ventromedial hypothalamic nucleus decreases anxiety in the elevated T-maze. Behavioural Brain Research, v. 216, n. 2, p. 692-698, JAN 20 2011. Web of Science Citations: 11.
DINIZ, L.; DOS SANTOS, T. B.; BRITTO, L. R. G.; CESPEDES, I. C.; GARCIA, M. C.; SPADARI-BRATFISCH, R. C.; MEDALHA, C. C.; DE CASTRO, G. M.; MONTESANO, F. T.; VIANA, M. B.. Effects of chronic treatment with corticosterone and imipramine on fos immunoreactivity and adult hippocampal neurogenesis. Behavioural Brain Research, v. 238, p. 170-177, FEB 1 2013. Web of Science Citations: 24.
DE PAULA, D. C.; TORRICELLI, A. S.; LOPREATO, M. R.; NASCIMENTO, J. O. G.; VIANA, M. B.. 5-HT2A receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze. Behavioural Brain Research, v. 226, n. 1, p. 50-55, JAN 1 2012. Web of Science Citations: 14.
BUENO‚ C.H.; ZANGROSSI‚ H.; VIANA‚ M.B.. GABA/benzodiazepine receptors in the ventromedial hypothalamic nucleus regulate both anxiety and panic-related defensive responses in the elevated t-maze. Brain Research Bulletin, v. 74, n. 1, p. 134-141, 2007.