Luiz Gonzaga Tone
CV Lattes
ResearcherID
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Medicina from Universidade de São Paulo (1972), master's at Pediatria Ribeirão Preto from Universidade de São Paulo (1978) and ph.d. at Pediatria Ribeirão Preto from Universidade de São Paulo (1983). He is currently full professor at Universidade de São Paulo. Has experience in Medicine, focusing on Child Health, acting on the following subjects: acute lymphoblastic leukemia, criança, childhood, pcr and children. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Novel technology developed to classify most common brain cancer in children |
- Interactions between emerging therapeutic targets and developmental pathways associated with tumorigenesis: emphasis on pediatric malignancies, AP.TEM
Abstract
Currently, even with intensive multimodal treatment, 20% of children and adolescents with cancer will still die due to disease and over 40% of survivors develop sequelae that affect the adult quality of life. Therefore, more effective and safer treatment options for children with cancer are still needed to increase cure rates, decrease toxicity and to minimize the risk of long term effe...
- Effects of tetra-O-methyl nordihydroguaiaretic acid in glioblastoma: a combined transcriptomic and proteomic study, AP.R
Abstract
Glioblastoma is one of the most aggressive human cancers. Despite current advances in multimodality therapies, such as surgery, radiotherapy and chemotherapy, the outcome for patients with this neoplasia remains fatal. Thus, novel effective treatment regimens are urgently needed.Tetra-O-methyl nordihydroguaiaretic acid (M4N), a global transcription inhibitor of Sp1-regulated genes, has ...
- Effects of inhibition of HDAC9 gene in acute lymphocytic leukemia, AP.R
Abstract
Acute Lymphoblastic Leukemia (ALL) is the most common hematologic malignancy in childhood. It's a heterogeneous disease and despite advances in treatment approximately 20% of patients have relapse or death indicating the need for differentiated therapies for this group. The analysis of genetic and epigenetic abnormalities may enable a more accurate diagnosis and the development of speci...
- Studies of potential therapeutic targets and biological pathways involved in medulloblastoma, AP.R
(Only some records are available in English at this moment)
- Study of the effects of DNA demethylation on genes associated with developmental pathways in pediatric Ependymomas, BP.DR
Abstract
Ependymoma (EPN) is a primary neuroepithelial Central Nervous System (CNS) tumor originated in ependymal cells. It is the third most frequent of CNS tumor in childhood and corresponds to 6 to 12% of pediatric intracranial tumors. Currently, the treatment is performed with surgical resection and radiotherapy. Clinical trials with chemotherapy have been performed, but have not shown promi...
- Technical support in the laboratory routine and the search for new therapeutic targets using bioinformatics tools, BP.TT
- "demethylation of specific tumor suppressor in medulloblastoma using dCas9-Tet1 system", BP.PD
Abstract
Medulloblastoma is the most commom tumor in the childhood. This tumor originates from cerebellum, and it is classified as an embryonic tumor. Biology of MB is intrinsically associated with deregulation of signaling pathways that control embryonic development of cerebellum. Therefore, the identification of alterations in molecular mechanisms could result in less toxicity and decrease of ...
- Investigation of Smad2/3-YAP complex as a chemoresistant factor in TP53, BP.PD
Abstract
Medulloblastoma is the most common malignant brain tumor in childhood and it is the main cause of morbidity and mortality in pediatric oncolology. Recent studies revelead 4 molecular subgroups of Medulloblastomas based on the transcriptional, mutational and cytogenetic profiles, these subgroups are: WNT, SHH, Group 3 and Group 4. The SHH molecular subgrupous which bears mutation in TP53...
- Investigation of new therapeutic targets from transcriptional networks of genes of the mitotic spindle associated with embryonic developmental pathways in the ependymoma: focus on molecular subgroups of worst outcome, BP.DR
Abstract
The ependymoma (EPN) is the third brain tumor most frequently in children, however it can also affect adolescents and adults. Despite the standard treatment (surgical resection followed by radiotherapy), about 50% of the patients with this kind of tumor die due resistance to therapies and local tumor recurrence. Because of this fact, genomic methods of high-throughput and computational ...
- Research therapeutic targets from gene expression networks of members of the TGF-b pathway associated with tumor progression of ependymomas of worse prognosis, BP.DR
Abstract
The ependymoma (EPN) is the third most frequently brain tumor in childhood, affecting intracranial region in 90% of cases. The treatment used today includes resection of the tumors followed by radiation, however even after treatment, a lot of patients will die because of resistance to therapy and tumor recurrence. The EPN is a heterogeneous disease, which the worst predictions are repre...
(Only some records are available in English at this moment)
- Understanding treatment resistance and evaluating new therapies for pediatric ependymoma, BE.EP.DR
Abstract
Ependymoma (EPN) is the third most frequent brain tumor in children. This tumor is a heterogeneous disease, which can be classified into nine molecular subgroups. The ST-EPN-YAP1 and ST-EPN-RELA subgroups affect children, with RELA-positive subgroup specifically associated with poor prognosis and resistance to therapy. DNA methylation, an epigenetic alteration, has been shown to be an i...
- The role of the Hedgehog signaling pathway in ependymoma, BE.EP.DR
Abstract
Ependymoma (EPN) is the third most frequent brain tumor in children. This tumor is a heterogeneous disease, which can be classified in nine molecular subgroups. The subgroups ST-EPN-YAP1, ST-EPN-RELA and FP-EPN-A are more frequent in children. ST-EPN-RELA and FP-EPN-A subgroups are associated with poor prognosis and resistance to therapy. Our project is focused on understanding specific...
- Novel strategies and therapeutic targets in medulloblastoma exploring tumor microenviroment trough in vivo models of subgroup SHH and group 3, BE.EP.PD
Abstract
Besides surgery, the standard treatment options for newly diagnosed medulloblastoma (MB) include radiotherapy and chemotherapy, which induce severe adverse effects and compromise the quality of life in pediatric patients. Group 2 (Sonic Hedgehog [SHH]) and Group 3 (MYC) MB tumors are highly aggressive with moderate and worst prognoses, respectively. These two subgroups also have an inta...
- Study of aurora kinases as potential biomarkers and its correlation with PKA dysfunction in adrenocortical tumors, BE.EP.PD
Abstract
Adrenocortical carcinomas are relatively rare tumors. However, a mutation in the TP53 gene, commonly found in Southern Brazil, increases the predisposition to the disease. There are no effective therapies for advanced stage adrenocortical carcinomas, which leads to a low survival index for patients with stage IV tumors. Therefore, discovery of new therapeutic targets and new methods for...
- Epigenetic regulation of retroelements by TET enzymes in neural precursor cells, BE.EP.DR
Abstract
Long interspersed nuclear elements (LINE-1 or L1) are classified as non-long terminal repeat (LTR) retroelements, which have the ability to replicate and reintegrate in the host genome. In neuronal precursor cells (NPCs), L1s are expressed and mobile. Somatic L1 insertions have been detected in protein-coding and tissue-specific genes. L1s therefore generate genetic somatic mosaicism in...
- In vitro characterization of molecular and functional differences between medulloblastoma subgroups, BE.EP.DR
Abstract
Medulloblastoma (MB) cell dissemination is at the origin of the leptomeningeal metastatic disease, which is a common and severe complication of this malignant, pediatric brain tumor. The molecular mechanisms that mediate MB cell dissemination are largely unknown and no targeted therapy exists to specifically block dissemination. Like many human tumors, MB disease is complex and consists...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 9 / 5 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 28 / 23 | Completed scholarships in Brazil |
| 3 / 3 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 49 / 40 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 58 |
| Citations | 654 |
| Cit./Article | 11.3 |
| Data from Web of Science | |
BORGES, KLEITON SILVA; BRASSESCO, MARIA SOL; SCRIDELI, CARLOS ALBERTO; EGEA SOARES, ADEMILSON ESPENCER; TONE, LUIZ GONZAGA. Antiproliferative effects of Tubi-bee propolis in glioblastoma cell lines. GENETICS AND MOLECULAR BIOLOGY, v. 34, n. 2, p. 310-314, 2011. Web of Science Citations: 17. (10/08699-5)
BORGES, KLEITON SILVA; CASTRO-GAMERO, ANGEL MAURICIO; MORENO, DANIEL ANTUNES; SILVEIRA, VANESSA DA SILVA; BRASSESCO, MARIA SOL; DE PAULA QUEIROZ, ROSANE GOMES; DE OLIVEIRA, HARLEY FRANCISCO; CARLOTTI, JR., CARLOS GILBERTO; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA. Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, v. 138, n. 3, p. 405-414, MAR 2012. Web of Science Citations: 31.
DE OLIVEIRA, JAQUELINE CARVALHO; SCRIDELI, CARLOS ALBERTO; BRASSESCO, MARIA SOL; MORALES, ANDRESSA GOIS; PEZUK, JULIA ALEJANDRA; QUEIROZ, ROSANE DE PAULA; YUNES, JOSE ANDRES; BRANDALISE, SILVIA REGINA; TONE, LUIZ GONZAGA. Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features. Leukemia Research, v. 36, n. 3, p. 293-298, MAR 2012. Web of Science Citations: 41. (09/10191-2)
ENGEL, E. E.; NOGUEIRA-BARBOSA, M. H.; BRASSESCO, M. S.; SILVA, G. E. B.; VALERA, E. T.; PERIA, F. M.; MOTTA, T. C.; TONE, L. G.. Osteosarcoma arising from osteochondroma of the tibia: case report and cytogenetic findings. Genetics and Molecular Research, v. 11, n. 1, p. 448-454, 2012. Web of Science Citations: 5.
BRASSESCO, MARIA S.; MONTALDI, ANA P.; GRAS, DIANA E.; CAMPAROTO, MARJORI L.; MARTINEZ-ROSSI, NILCE M.; SCRIDELI, CARLOS A.; TONE, LUIZ G.; SAKAMOTO-HOJO, ELZA T.. Cytogenetic and molecular analysis of MLL rearrangements in acute lymphoblastic leukaemia survivors. MUTAGENESIS, v. 24, n. 2, p. 153-160, MAR 2009. Web of Science Citations: 9.
ENGEL, EDGARD EDUARD; BRASSESCO, MARIA SOL; VALERA, ELVIS TERCI; NOGUEIRA-BARBOSA, MARCELLO HENRIQUE; DE ALMEIDA SANTOS YAMASHITA, MAURICIO EIJI; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA. Clinico-genetic aspects of a pediatric non-neurofibromatosis type 1 malignant triton tumor with loss of chromosome X. PEDIATRIC BLOOD & CANCER, v. 59, n. 7, p. 1320-1323, DEC 2012. Web of Science Citations: 2. (10/15717-0, 10/16652-9)
VALERA, ELVIS TERCI; BRASSESCO, MARIA SOL; SCRIDELI, CARLOS ALBERTO; DE CASTRO BARROS, MARCUS VINICIUS; SANTOS, ANTONIO CARLOS; OLIVEIRA, RICARDO SANTOS; MACHADO, HELIO RUBENS; TONE, LUIZ GONZAGA. Are patients with encephalocraniocutaneous lipomatosis at increased risk of developing low-grade gliomas?. CHILD'S NERVOUS SYSTEM, v. 28, n. 1, p. 19-22, JAN 2012. Web of Science Citations: 12. (10/15717-0, 10/16652-9)
BRASSESCO, MARIA SOL; XAVIER, DANILO JORDAO; CAMPAROTO, MARJORI LEIVA; MONTALDI, ANA PAULA; D'AURIA VIEIRA DE GODOY, PAULO ROBERTO; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA; SAKAMOTO-HOJO, ELZA TIEMI. Cytogenetic Instability in Childhood Acute Lymphoblastic Leukemia Survivors. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011. Web of Science Citations: 5.
BRASSESCO, M. S.; VALERA, E. T.; CASTRO-GAMERO, A. M.; MORENO, D. A.; SILVEIRA, T. P.; MORI, B. M.; ENGEL, E. E.; SCRIDELI, C. A.; TONE, L. G.. Cytogenetic findings in an epithelioid sarcoma with angiomatoid features. A case report. Genetics and Molecular Research, v. 8, n. 4, p. 1211-1217, 2009. Web of Science Citations: 3.
SILVEIRA, VANESSA S.; SCRIDELI, CARLOS ALBERTO; MORENO, DANIEL A.; YUNES, JOSE ANDRES; QUEIROZ, ROSANE G. P.; TOLEDO, SILVIA C.; LEE, MARIA LUCIA M.; PETRILLI, ANTONIO S.; BRANDALISE, SILVIA R.; TONE, LUIZ GONZAGA. Gene expression pattern contributing to prognostic factors in childhood acute lymphoblastic leukemia. Leukemia & Lymphoma, v. 54, n. 2, p. 310-314, FEB 2013. Web of Science Citations: 18. (01/13206-9)
BORGES, KLEITON S.; ARBOLEDA, VALERIE A.; VILAIN, ERIC. Mutations in the PCNA-binding site of CDKN1C inhibit cell proliferation by impairing the entry into S phase. CELL DIVISION, v. 10, MAR 28 2015. Web of Science Citations: 1. (12/09391-0)
CASTRO-GAMERO, ANGEL MAURICIO; BORGES, KLEITON SILVA; MORENO, DANIEL ANTUNES; SUAZO, VERIDIANA KILL; FUJINAMI, MAYARA MISSONO; GOMES QUEIROZ, ROSANE DE PAULA; DE OLIVEIRA, HARLEY FRANCISCO; CARLOTTI, JR., CARLOS GILBERTO; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA. Tetra-O-methyl nordihydroguaiaretic acid, an inhibitor of Sp1-mediated survivin transcription, induces apoptosis and acts synergistically with chemo-radiotherapy in glioblastoma cells. INVESTIGATIONAL NEW DRUGS, v. 31, n. 4, p. 858-870, AUG 2013. Web of Science Citations: 15.
ANDRADE, AUGUSTO F.; BORGES, KLEITON S.; CASTRO-GAMERO, ANGEL M.; SILVEIRA, VANESSA S.; SUAZO, VERIDIANA K.; OLIVEIRA, JAQUELINE C.; MORENO, DANIEL A.; DE PAULA QUEIROZ, ROSANE G.; SCRIDELI, CARLOS A.; TONE, LUIZ G.. Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells. ANTI-CANCER DRUGS, v. 25, n. 1, p. 72-81, JAN 2014. Web of Science Citations: 16. (10/14378-7)
MORALES, ANDRESSA GOIS; PEZUK, JULIA ALEJANDRA; BRASSESCO, MARIA SOL; DE OLIVEIRA, JAQUELINE CARVALHO; DE PAULA QUEIROZ, ROSANE GOMES; MACHADO, HELIO RUBENS; CARLOTTI, JR., CARLOS GILBERTO; NEDER, LUCIANO; DE OLIVEIRA, HARLEY FRANCISCO; SCRIDELI, CARLOS ALBERTO; et al. BUB1 and BUBR1 inhibition decreases proliferation and colony formation, and enhances radiation sensitivity in pediatric glioblastoma cells. CHILD'S NERVOUS SYSTEM, v. 29, n. 12, p. 2241-2248, DEC 2013. Web of Science Citations: 11. (09/09305-3)
SILVEIRA‚ V.D.S.; CANALLE‚ R.; SCRIDELI‚ C.A.; QUEIROZ‚ R.G.P.; TONE‚ L.G.. Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes in a Brazilian population. BIOMARKERS, v. 14, n. 2, p. 111-117, 2009.
BRASSESCO, MARIA SOL; VALERA, ELVIS TERCI; NEDER, LUCIANO; CASTRO-GAMERO, ANGEL MAURICIO; DE OLIVEIRA, FABIO MORATO; SANTOS, ANTONIO CARLOS; SCRIDELI, CARLOS ALBERTO; OLIVEIRA, RICARDO SANTOS; MACHADO, HELIO RUBENS; TONE, LUIZ GONZAGA. Childhood radiation-associated atypical meningioma with novel complex rearrangements involving chromosomes 1 and 12. NEUROPATHOLOGY, v. 29, n. 5, p. 585-590, 2009. Web of Science Citations: 9.
VALERA‚ E.T.; BRASSESCO‚ M.S.; CASTRO-GAMERO‚ A.M.; SANTOS‚ A.C.; OLIVEIRA‚ R.S.; MACHADO‚ H.R.; NEDER‚ L.; SAKAMOTO-HOJO‚ E.T.; TONE‚ L.G.. Multiple dicentric chromosomes behind polyploidy in grade II atypical choroid plexus papilloma: a complementary cytogenetic evaluation. NEUROPATHOLOGY, v. 29, n. 2, p. 200-202, 2009.
BRASSESCO, MARIA SOL; VALERA, ELVIS TERCI; ENGEL, EDGARD EDUARD; NOGUEIRA-BARBOSA, MARCELLO HENRIQUE; BECKER, ALINE PAIXAO; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA. Clonal Complex Chromosome Aberration in Non-Ossifying Fibroma. PEDIATRIC BLOOD & CANCER, v. 54, n. 5, p. 764-767, 2010. Web of Science Citations: 3.
VALERA‚ E.T.; BRASSESCO‚ M.S.; DE FREITAS CORTEZ‚ M.A.A.; QUEIROZ‚ R.G.; CASTRO-GAMERO‚ A.M.; BARROS‚ M.V.C.; VICENTE‚ Y.A.; JUNIOR‚ S.T.; SCRIDELI‚ C.A.; TONE‚ L.G.. Pitfalls in the differential diagnosis of renal tumor in an adolescent. PEDIATRIC BLOOD & CANCER, v. 54, n. 2, p. 319-321, 2010.
VALERA‚ E.T.; BRASSESCO‚ M.S.; GERMESHAUSEN‚ M.; SILVEIRA‚ V.S.; DE PAULA QUEIROZ‚ R.G.; ROXO‚ P.; SCRIDELI‚ C.A.; DE MENEZES‚ U.P.; FERRIANI‚ V.; TONE‚ L.G.. Acute lymphoblastic leukemia following severe congenital neutropenia or de novo ALL?. Leukemia Research, v. 33, n. 9, p. e139-e142, 2009.
SCRIDELI, CARLOS ALBERTO; ABDALA CORTEZ, MARIA ANGELICA; YUNES, JOSE ANDRES; DE PAULA QUEIROZ, ROSANE GOMES; VALERA, ELVIS TERCI; DA MATA, JULIANA FRANCA; CAMINADA TELEDO, SILVIA REGINA; PAVONI-FERREIRA, PRISCILA; DE MARTINO LEE, MARIA LUCIA; PETRILLI, ANTONIO SERGIO; et al. mRNA expression of matrix metalloproteinases (MMPs) 2 and 9 and tissue inhibitor of matrix metalloproteinases (TIMPs) 1 and 2 in childhood acute lymphoblastic leukemia: Potential role of TIMP1 as an adverse prognostic factor. Leukemia Research, v. 34, n. 1, p. 32-37, 2010. Web of Science Citations: 16. (01/13206-9)
ROBERTO, GABRIELA MOLINARI; ENGEL, EDGARD EDUARD; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA; BRASSESCO, MARIA SOL. Downregulation of miR-10B{*}is correlated with altered expression of mitotic kinases in osteosarcoma. PATHOLOGY RESEARCH AND PRACTICE, v. 214, n. 2, p. 213-216, FEB 2018. Web of Science Citations: 5. (15/00524-5)
VIEIRA, GABRIELA MACIEL; ROBERTO, GABRIELA MOLINARI; LIRA, REGIA CAROLINE; ENGEL, EDGARD EDUARD; TONE, LUIZ GONZAGA; BRASSESCO, MARIA SOL. Prognostic value and functional role of ROCK2 in pediatric Ewing sarcoma. Oncology Letters, v. 15, n. 2, B, p. 2296-2304, FEB 2018. Web of Science Citations: 0. (14/07118-0, 14/03877-3)
ANDRADE, AUGUSTO FARIA; BORGES, KLEITON SILVA; SUAZO, VERIDIANA KIILL; GERON, LENISA; PEREIRA CORREA, CAROLINA ALVES; CASTRO-GAMERO, ANGEL MAURICIO; ROSAS DE VASCONCELOS, ELTON JOSE; DE OLIVEIRA, RICARDO SANTOS; NEDER, LUCIANO; YUNES, JOSE ANDRES; et al. The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma. INVESTIGATIONAL NEW DRUGS, v. 35, n. 1, p. 26-36, FEB 2017. Web of Science Citations: 10. (11/22440-7)
BRANDALISE, SILVIA R.; PINHEIRO, VITORIA R.; AGUIAR, SIMONE S.; MATSUDA, EDUARDO I.; OTUBO, ROSEMARY; YUNES, JOSE A.; PEREIRA, WALDIR V.; CARVALHO, ENY G.; CRISTOFANI, LILIAN M.; SOUZA, MARCELO S.; et al. Benefits of the Intermittent Use of 6-Mercaptopurine and Methotrexate in Maintenance Treatment for Low-Risk Acute Lymphoblastic Leukemia in Children: Randomized Trial From the Brazilian Childhood Cooperative Group Protocol ALL-99. Journal of Clinical Oncology, v. 28, n. 11, p. 1911-1918, APR 10 2010. Web of Science Citations: 44. (01/13206-9)
GERON, LENISA; BORGES, KLEITON SILVA; ANDRADE, AUGUSTO FARIA; SUAZO, VERIDIANA KILL; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA. Antitumour activity of AMG 900 alone or in combination with histone deacetylase inhibitor SaHa on medulloblastoma cell lines. NEUROLOGICAL RESEARCH, v. 37, n. 8, p. 703-711, AUG 2015. Web of Science Citations: 3. (11/15645-1)
SILVEIRA, VANESSA S.; FREIRE, BRUNO M. R.; BORGES, KLEITON S.; ANDRADE, AUGUSTO F.; CRUZEIRO, GUSTAVO A. V.; SABINO, JOAO PAULO J.; GLASS, MOGENS LESNER; YUNES, JOSE ANDRES; BRANDALISE, SILVIA REGINA; TONE, LUIZ GONZAGA; et al. Hypoxia-related gene expression profile in childhood acute lymphoblastic leukemia: prognostic implications. Leukemia & Lymphoma, v. 55, n. 8, p. 1751-1757, AUG 2014. Web of Science Citations: 7. (10/07020-9, 10/06067-1)
BORGES, KLEITON SILVA; MORENO, DANIEL ANTUNES; MARTINELLI, JR., CARLOS EDUARDO; RAUBER ANTONINI, SONIR ROBERTO; DE CASTRO, MARGARET; TUCCI, JR., SILVIO; NEDER, LUCIANO; ZAMBELLI RAMALHO, LEANDRA NAIRA; SEIDINGER, ANA LUIZA; CARDINALLI, IZILDA; et al. Spindle Assembly Checkpoint Gene Expression in Childhood Adrenocortical Tumors (ACT): Overexpression of Aurora Kinases A and B Is Associated With a Poor Prognosis. PEDIATRIC BLOOD & CANCER, v. 60, n. 11, p. 1809-1816, NOV 2013. Web of Science Citations: 14. (10/08699-5)
PEZUK, J. A.; BRASSESCO, M. S.; MORALES, A. G.; DE OLIVEIRA, J. C.; DE PAULA QUEIROZ, R. G.; MACHADO, H. R.; CARLOTTI, JR., C. G.; NEDER, L.; SCRIDELI, C. A.; TONE, L. G.. Polo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma. Cancer Gene Therapy, v. 20, n. 9, p. 499-506, SEP 2013. Web of Science Citations: 28. (09/11053-2)
PEZUK, JULIA ALEJANDRA; BRASSESCO, MARIA SOL; DE OLIVEIRA, RICARDO SANTOS; MACHADO, HELIO RUBENS; NEDER, LUCIANO; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA. PLK1-associated microRNAs are correlated with pediatric medulloblastoma prognosis. CHILD'S NERVOUS SYSTEM, v. 33, n. 4, p. 609-615, APR 2017. Web of Science Citations: 6. (11/01026-8, 11/11287-3)
PEZUK, JULIA ALEJANDRA; BRASSESCO, MARIA SOL; MORALES, ANDRESSA GOIS; DE OLIVEIRA, JAQUELINE CARVALHO; DE OLIVEIRA, HARLEY FRANCISCO; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA. Inhibition of Polo-Like Kinase 1 Induces Cell Cycle Arrest and Sensitizes Glioblastoma Cells to Ionizing Radiation. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, v. 28, n. 7, p. 516-522, SEP 2013. Web of Science Citations: 12. (09/11053-2)
BORGES, KLEITON S.; ANDRADE, AUGUSTO F.; SILVEIRA, VANESSA S.; MARCO ANTONIO, DAVID S.; VASCONCELOS, ELTON J. R.; ANTONINI, SONIR R. R.; TONE, LUIZ G.; SCRIDELI, CARLOS A.. The aurora kinase inhibitor AMG 900 increases apoptosis and induces chemosensitivity to anticancer drugs in the NCI-H295 adrenocortical carcinoma cell line. ANTI-CANCER DRUGS, v. 28, n. 6, p. 634-644, JUL 2017. Web of Science Citations: 8. (10/07020-9, 10/08699-5)
PEZUK, JULIA ALEJANDRA; BRASSESCO, MARIA SOL; MANZINI RAMOS, PRISCILA MARIA; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA. Polo-Like Kinase 1 Pharmacological Inhibition as Monotherapy or in Combination: Comparative Effects of Polo-Like Kinase 1 Inhibition in Medulloblastoma Cells. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 17, n. 9, p. 1278-1291, 2017. Web of Science Citations: 3. (11/01026-8, 11/11287-3)
VEIGA CRUZEIRO, GUSTAVO ALENCASTRO; DOS REIS, MARISTELLA BERGAMO; SILVEIRA, VANESSA SILVA; PEIXOTO LIRA, REGIA CAROLINE; CARLOTTI, CARLOS GILBERTO; NEDER, LUCIANO; OLIVEIRA, RICARDO SANTOS; YUNES, JOSE ANDRES; BRANDALISE, SILVIA REGINA; AGUIAR, SIMONE; et al. HIF1A is Overexpressed in Medulloblastoma and its Inhibition Reduces Proliferation and Increases EPAS1 and ATG16L1 Methylation. CURRENT CANCER DRUG TARGETS, v. 18, n. 3, p. 287-294, 2018. Web of Science Citations: 2. (11/04682-3, 12/06592-4)
BRASSESCO, MARIA SOL; MONTALDI, ANA PAULA; GRAS, DIANA ESTER; DE PAULA QUEIROZ, ROSANE GOMES; MARTINEZ-ROSSI, NILCE MARIA; TONE, LUIZ GONZAGA; SAKAMOTO-HOJO, ELZA TIEMI. MLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals. GENETICS AND MOLECULAR BIOLOGY, v. 32, n. 2, p. 234-241, 2009. Web of Science Citations: 6.
BRASSESCO, MARIA SOL; VALERA, ELVIS TERCI; DE OLIVEIRA, FABIO MORATO; DE PAULA QUEIROZ, ROSANE GOMES; SCRIDELI, CARLOS ALBERTO; SAKAMOTO-HOJO, ELZA TIEMI; TONE, LUIZ GONZAGA. 8q Deletion in MYCN-amplified Neuroblastoma of a Child Born From Assisted Reproductive Technology. JOURNAL OF PEDIATRIC HEMATOLOGY / ONCOLOGY, v. 31, n. 3, p. 215-219, MAR 2009. Web of Science Citations: 3.
SALOMAO, KARINA BEZERRA; VEIGA CRUZEIRO, GUSTAVO ALENCASTRO; BONFIM-SILVA, RICARDO; GERON, LENISA; RAMALHO, FERNANDO; SAGGIORO, FABIANO PINTO; SERAFINI, LUCIANO NEDER; ANTUNES MORENO, DANIEL; DE PAULA QUEIROZ, ROSANE GOMES; AGUIAR, SIMONE DOS SANTOS; et al. Reduced hydroxymethylation characterizes medulloblastoma while TET and IDH genes are differentially expressed within molecular subgroups. JOURNAL OF NEURO-ONCOLOGY, v. 139, n. 1, p. 33-42, AUG 2018. Web of Science Citations: 0. (13/15125-3, 14/20341-0)
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