CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Otávio Cabral-Marques is an Associate Professor of Molecular Medicine at the Faculty of Medicine of the University of São Paulo (FM-USP), in the Department of Internal Medicine. He represents the category of Associate Professor (MS-3) on the Council of the aforementioned Department. He is a researcher at IDOR. His work involves integrative systemic analysis of neuroimmunological networks to understand the immune response and new molecular mechanisms in depression, infections, autoimmune diseases, and cancer. Previously, he held the position of Visiting Full Professor in the Department of Pharmacy at the Health Sciences Center of the Federal University of Rio Grande do Norte, from August 29, 2022, to April 10, 2023. Currently, he serves as a Full Advisor in the Departments of Internal Medicine, Immunology, and the Faculty of Pharmaceutical Sciences (FCF/USP), as well as a Part-time Advisor in the Interunit Graduate Program in Bioinformatics at the University of São Paulo (USP). He holds a degree in Biology from the Regional University of Blumenau (2001-2005), earned a Master's degree (2006-2008), and a PhD (2008-2012) in Immunology from the Institute of Biomedical Sciences at USP. He completed a Sandwich PhD at the University of Washington School of Medicine and the Seattle Children's Research Institute, in Seattle, WA, USA, from December 2010 to May 2011. He also did postdoctoral work in Brazil (University of São Paulo; 2012-2015) and in Germany (Department of Rheumatology and Clinical Immunology, University of Lübeck: October 2015 to April 2019; and Center for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg: April 2015 to November 2019). Additionally, he serves as Junior Ambassador of Brazil in the Network of Immunity in Infection, Malignancy, and Autoimmunity (NIIMA), part of the Universal Scientific Education and Research Network (USERN). He can be contacted via email at (Source: Lattes Curriculum)
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Outbreaks of arboviruses such as Zika e Dengue in the Americas have led to a state of international public emergency. The viruses are transmitted by the same vector mosquito (Aedes aegypti), have co-circulated throughout the world, and trigger common clinical features. Despite the global health problems caused by these etiological agents, there is a scarce knowledge about the systemic imm…
The current pandemic of the Coronavirus respiratory disease 2019 (COVID-19) represents a state of international public emergency. The virus causing the disease is called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been circulating throughout the world, triggering clinical manifestations ranging from asymptomatic cases to severe acute respiratory syndrome and death…
Autoantibodies (AAbs) are antibodies which react with self-molecules (autoantigens). Molecules whose own existence and functionality were once contested, have now been accepted in the context of autoimmune diseases. Although considered mainly pathological, these are ubiquitously present molecules which contribute to homeostasis. One particular class of are the functional AAbs, which can b…
The Coronavirus Disease 2019 (COVID-19) pandemic has left many psychopathological implications in COVID-19 survivors, such as depression, anxiety and cognitive impairments, which are now recognized as primary symptoms of "post-acute COVID-19 syndrome"11 . Depressive psychopathology has already been reported in about 35% of patients in short, medium and long-term follow-up after infection …
(Only some records are available in English at this moment)
Viral infections affecting the Central Nervous System (CNS) represent an emergent cause of illness and mortality in Brazil and worldwide. The emergence, re-emergence, and dysfunctions associated with neuroglial infections by viruses with neurotropic properties, such as ZIKV and DENV flaviviruses, SARS-CoV-2 and Rabies Virus (RABV), justify the need to understand the commonality and differ…
Notably, anti-cytokine autoantibodies have been linked to the development of opportunistic infections. Among them, anti-IFN-gamma neutralizing autoantibodies can increase the susceptibility to mycobacterial infections, while anti-IFN-alpha are associated with the development of viral infections (e.g., chickenpox, cytomegalovirus, and adenovirus) and cancer. However, the concentration of a…
Outbreaks of arboviruses such as Zika infections in the Americas have led to a state of international public emergency. The Zika virus (ZIKV) is transmitted by the mosquito Aedes aegypti, have co-circulated throughout the world, and trigger common clinical features. Despite the global health problems caused by this etiological agent, there is a scarce knowledge about the systemic immunolo…
(Only some records are available in English at this moment)
We recently showed that older patients with severe COVID-19 have high levels of autoantibodies (aab) against molecules targeting Cardiolipin and Platelet glycoprotein compared to healthy controls. In this case, we found that, in particular, anti-cardiolipin1 and anti-platelet antibodies increase the risk of thrombosis-related events such as pulmonary thromboembolism and deep vein thrombos…
The immune system plays an important role in the homeostatic control of the body. For this fundamental function, the system is activated in response to external or internal injuries. Therefore, the activation mechanisms of the immune system are important and desirable but must be finely controlled to avoid immunopathology. Several evolutionary conserved immunoregulatory mechanisms such as…
Dengue disease is a global health problem that affects approximately 390 million people per year, in over 120 countries but no specific therapy or vaccine is currently available to effectively combat dengue virus (DENV) infection. While most of the individuals infected by DENV are asymptomatic or present uncomplicated symptoms, 5-20% of the patients develop severe dengue (SD) in several d…
| 1 / 1 | Ongoing research grants |
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| 5 / 5 | Ongoing scholarships in Brazil |
| 8 / 7 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 19 / 18 | All research grants and scholarships |
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