CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Odontologia (FOAr) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from the State University of Campinas (1997), Master in Pathology Oral-Dental Biology from the State University of Campinas (2000), PhD in Oral-Dental Biology from the State University of Campinas (2002) and Postdoctoral Fellow in Mutagenesis the Faculty of Medicine of Ribeirão Preto, FMRP-USP (2010). Currently, I am working as Adjunct Professor in the School of Dentistry at Araraquara - UNESP, Univ Estadual Paulista, responsible for teaching Human Genetics. Have experience in dentistry, with emphasis on Genetics Susceptibility to Periodontal Disease with or without Diabetes and Dyslipidemia, particularly investigating: genetic polymorphisms and their functionality, gene expression, Immunogenetics, dysmorphology and Down Syndrome. As a new line of research I have been investigating cytotoxicity, genotoxicity and mutagenicity of Biomaterials. E-mail contact: raquel@foar.unesp.br (Source: Lattes Curriculum)
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It has been more frequent to find patients affected by the combination of Type 2 Diabetes Mellitus (T2DM), Dyslipidemia and Periodontitis (P). There is increasing evidence in the literature in demonstrating interactions between T2DM, dyslipidemia, immune system alterations and Periodontitis. For a better understanding of such interactions, studies with animal models, mainly murine, have b…
The present application is intended to enable the visit of the Researcher Dr. Jeronimo C. Ruiz, Principal Researcher of the Oswaldo Cruz Foundation (RENE RACHOU Institute - IRR, Belo Horizonte, MG) to the School of Dentistry of Araraquara - FOAr UNESP to enable collaboration in the Bioinformatics area of 4 main projects (and others related) of the Responsible Researcher Dr. Raquel M.Scare…
Although evidences show association of polymorphisms in cytokine genes with susceptibility to chronic periodontitis (CP), there are many genes (e.g metabolism) that may affect the pathogenesis of PC that have not yet been investigated. Therefore, further studies are needed to identify polymorphisms associated with periodontal disease (PD) which can be used as genetic markers of PD in our …
We aim to establish the bases for the development of new strategies for the control of periodontitis. Our hypothesis is that the balance between the oral microbiota-immune response, lost in periodontitis, could be obtained by favoring the colonization of the oral cavity with beneficial bacterial species and by modulating the immune response. The first project aims to test if saliva differ…
(Only some records are available in English at this moment)
The incidence of patients affected simultaneously by Type 2 Diabetes Mellitus (T2DM), Dyslipidemia and Periodontitis (P) is increasing. Also increases the evidence in the literature demonstrating interactions among these pathologies, mediated by immune system dysfunction and higher glyco-oxidative stress. In order to contribute, our research group is developing the project "Morpho-functio…
Type 2 Diabetes Mellitus (DM2) and Periodontitis (P) are two diseases that have been increasingly common in patients at the present time. Periodontitis is a multifactorial immunoinflammatory disorder mediated by the host in response to microbial dysbiosis, and has been recognized as the sixth major complication associated with T2DM, as a greater extent and severity of Periodontitis was de…
It has been found more frequently patients affected by a combination of Type 2 Diabetes Mellitus (T2DM), Dyslipidemia, and Periodontitis (P). Evidence in the literature is increasing in demonstrating interactions between T2DM, Dyslipidemia, immune system dysfunction, and Periodontitis. For a better understanding of such interactions, and to know molecules with a key role on them, it is va…
(Only some records are available in English at this moment)
Evidence on the relationship of antimicrobial peptides, such as defensins, with inflammatory and / or systemic diseases is increasing. The periodontal disease (PD), which is characterized as the main cause of dental loss in adults, has a multifactorial character, influenced by the presence of periodontopathogenic microorganisms, host genetic susceptibility, immune system reaction, smoking…
Diabetes mellitus type 2 (DM2) and Dyslipidemia systemic diseases are involved in the pathogenesis of periodontal disease (PD) and may alter the immune-inflammatory response of the host. The objective of this study is to investigate the expression of genes involved in the inflammatory process interleukin 7 (IL7) and Profilin 1 (PFN1) in patients with DM2 (compensated and decompensated), D…
The Molar-Incisor Hypomineralization (MIH) is a development enamel defect that shows an idiopathic origin, and affects one or more permanent first molars and can be associated with permanent incisors. From etiological aspect, it can be considered a multifactorial and complex condition. Recently, MIH has associated with enamel formation related genes, and although it has a well-established…
(Only some records are available in English at this moment)
Molar-Incisor Hypomineralization (MIH) is an enamel defect of systemic origin that affects one or more permanent primary molars, and may or may not be associated with the permanent incisors. From the etiological point of view, this condition may be considered multifactorial and complex. Recently, genetic variants such as polymorphisms and some genes related for enamel formation were assoc…
Many studies around the world have investigated genetic polymorphisms associated with susceptibility to periodontal disease (PD), but more studies are need to know risk factors to chronic periodontitis (CP) in the Brazilian population, mainly because its miscegenation. Moreover, there are few studies focused on identifying biological functionality of polymorphisms in the context of PD. Th…
The aim of this study is to investigate the salivary and plasma proteome related to individuals affected by type 2 Diabetes Mellitus (DM2, metabolically compensated/decompensated), Dyslipidemia and Chronic Periodontal Disease (DP). The development of this study proposes to complement the recently completed PhD study from the requestor (FAPESP 2009/16233-9 and 2010/10882-2) in which five g…
| 1 / 1 | Ongoing research grants |
| 9 / 9 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 26 / 21 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 43 / 38 | All research grants and scholarships |
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