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Rafael Junqueira Borges

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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Graduated in Biological Sciences - Medical emphasis in IBB (Biosciences Institute of Botucatu) - UNESP (Universidade Estadual Paulista Júlio de Mesquita Filho) - Campus Botucatu (2009). He had his master degree in the Biological Sciences with emphasis in Genetics (2012). In 2017, he obtained a co-tutela PhD degree in Biological Sciences with emphasis in Genetics (IBB-UNESP) and in Biotechnology (Facultat de Farmacia, Universitat Barcelona). Since 2007, he works in the Structural Molecular Biology in the Departament of Physics and Biophysics under supervision of Prof. Marcos Fontes, where he works with snake venom purification, x-ray crystallography, docking, molecular dynamics, Small-angle X-ray scattering (SAXS), circular dichroism (CD), dynamic light scattering (DLS). In 2016, he started a collaboration with Dr. Isabel Usón from Barcelona in the development of methods to aid crystallographic structure elucidation. He is the developer of the software SEQUENCE SLIDER, that pushed the limits of ARCIMBOLDO, the ab initio macromolecule phasing method of Dr. Usón, to larger structures and lower resolution datasets. SLIDER improves ARCIMBOLDO or Molecular Replacement (MR) partial solution by assembling different sequence hypotheses (modeling side chains) and pushing it through refinement, improvement in phases allow SHELXE autotracing to reveal rest of the structure. During the last few years, he spent 4 months in Dr. George Sheldrick laboratory in University of Goettingen (Germany), where he learnt to use the SHELX package, and 6 months in Dr. Randy Read laboratory in Cambridge University (United Kingdom), where he improved his knowledge about MR, software PHASER and statistics. Now, he is a Post-doctoral researcher under supervision of Prof. Marcos Fontes and Dr. Usón with FAPESP scholarship, integrating cryoelectron microscopy and electron diffraction in ARCIMBOLDO and developing SLIDER applied to natural compounds. (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Data from Web of Science

BOLDRINI-FRANCA, JOHARA; PINHEIRO-JUNIOR, ERNESTO LOPES; PEIGNEUR, STEVE; PUCCA, MANUELA BERTO; CERNI, FELIPE AUGUSTO; BORGES, RAFAEL JUNQUEIRA; COSTA, TASSIA RAFAELLA; IMAI CARONE, SANTE EMMANUEL; DE MATTOS FONTES, MARCOS ROBERTO; SAMPAIO, SUELY VILELA; et al. Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities. SCIENTIFIC REPORTS, v. 10, n. 1, . Web of Science Citations: 1. (15/17286-0, 15/00740-0, 18/14158-9, 17/13485-3, 11/23236-4, 16/24191-8, 14/16182-3, 17/14035-1, 16/04761-4, 15/16714-8, 15/18432-0)

CHI, JORDI; COVA, MARTA; DE LAS RIVAS, MATILDE; MEDINA, ANA; BORGES, RAFAEL JUNQUEIRA; LEIVAR, PABLO; PLANAS, ANTONI; USON, ISABEL; HURTADO-GUERRERO, RAMON; IZQUIERDO, LUIS. Plasmodium falciparum Apicomplexan-Specific Glucosamine-6-Phosphate N-Acetyltransferase Is Key for Amino Sugar Metabolism and Asexual Blood Stage Development. MBIO, v. 11, n. 5, . Web of Science Citations: 0. (16/24191-8)

BORGES, RAFAEL J.; CARDOSO, FABIO F.; FERNANDES, CARLOS A. H.; DREYER, THIAGO R.; DE MORAES, DELKIA S.; FLORIANO, RAFAEL S.; RODRIGUES-SIMIONI, LEA; FONTES, MARCOS R. M.. Functional and structural studies of a Phospholipase A(2)-like protein complexed to zinc ions: Insights on its myotoxicity and inhibition mechanism. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 1, A, p. 3199-3209, . Web of Science Citations: 10. (15/17286-0, 13/00873-4)

RICHARDS, LOGAN S.; MILLAN, CLAUDIA; MIAO, JENNIFER; MARTYNOWYCZ, MICHAEL W.; SAWAYA, MICHAEL R.; GONEN, TAMIR; BORGES, RAFAEL J.; USON, ISABEL; RODRIGUEZ, JOSE A.. Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, v. 76, n. 8, p. 703-712, . Web of Science Citations: 0. (16/24191-8, 17/13485-3)

SALVADOR, GUILHERME H. M.; BORGES, RAFAEL J.; EULALIO, MICAELA M. C.; DOS SANTOS, LUCILENE D.; FONTES, MARCOS R. M.. Biochemical, pharmacological and structural characterization of BmooMP-I, a new P-I metalloproteinase from Bothrops moojeni venom. Biochimie, v. 179, p. 54-64, . Web of Science Citations: 0. (16/24191-8)

MEDINA, ANA; TRIVINO, JOSEP; BORGES, RAFAEL J.; MILLAN, CLAUDIA; USON, ISABEL; SAMMITO, MASSIMO D.. ALEPH: a network-oriented approach for the generation of fragment-based libraries and for structure interpretation. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, v. 76, n. 3, p. 193-208, . Web of Science Citations: 2. (17/13485-3, 16/24191-8)

BORGES, RAFAEL JUNQUEIRA; MEINDL, KATHRIN; TRIVINO, JOSEP; SAMMITO, MASSIMO; MEDINA, ANA; MILLAN, CLAUDIA; ALCORLO, MARTIN; HERMOSO, JUAN A.; FONTES, MARCOS ROBERTO DE MATTOS; USON, ISABEL. SEQUENCE SLIDER: expanding polyalanine fragments for phasing with multiple side-chain hypotheses. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, v. 76, n. 3, p. 221-237, . Web of Science Citations: 0. (16/24191-8, 17/13485-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BORGES, Rafael Junqueira. Structural studies of PLA2-like toxins and development of the structure solution method sequence slider. Tese (Doutorado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  (13/00873-4

BORGES, Rafael Junqueira. Estudos estruturais com fosfolipases A2 homólogas de veneno botrópicos em presença de íons com importância funcional.  112 f. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu).  Botucatu.  (09/12155-3

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