Márcia Guimarães da Silva

• Abstract

  Although the etiology of preterm delivery is multifactorial, several microorganisms have been associated with its pathogenesis since the bacterial species most frequently isolated in the amniotic fluid of patients with intra-amniotic infection are commonly found in the vaginal microbiota. The infection of the amniotic cavity is the main cause of spontaneous preterm delivery, there is a co…

  Polybacterial infection of the amniochorion membranes: temporal regulation of microbial interaction and inflammatory/oxidative response, AP.R
• 3rd Infectious Diseases in Obstetrics and Gynecology, AR.EXT

• Abstract

  The current proposal is based on the proteomic and metabolomics study of the cervicovaginal content in response to different vaginal microbiome composition in reproductive-aged Brazilian women. Also, considering the role of the microbiome in the Human Papilomavirus (HPV) infection clearance the aim of this study is to determine the changes in proteins and metabolites associated with diffe…

  Analysis and characterization of bacterial proteins and metabolites during human Papillomavirus infection according to the vaginal microbiome composition of reproductive-aged women, AP.R SPRINT

(Only some records are available in English at this moment)

• Abstract

  Preterm Premature Rupture of Membranes (PPROM) and Preterm Labor (PTL) with intact membranes are one of the main problems in Obstetrics. Although many risk factors are shared between these unfavorable gestational outcomes and present overlapping mechanisms, is suggested that PPROM and PTL have a singular inflammatory and oxidative signature. Oxidative stress-induced senescence in fetal me…

  Senescence associated with inflammation in chorioamniotic membranes of pregnancies complicated by PPROM and PTL, BP.IC

• Abstract

  Although the etiology of preterm birth is multifactorial, several microorganisms have been associated with its pathogenesis, since the bacterial species most frequently included in the amniotic fluid of patients with intra-amniotic infection are bacteria associated with bacterial vaginosis. Even though the infection of the amniotic cavity is the main cause of spontaneous preterm birth, th…

  Temporal regulation of the inflammatory response in in vitro models of polybacterial infection of immortalized amniotic epithelial cells with different bacterial species associated with preterm birth, in the presence of Lactobacillus spp., BP.IC
• Polybacterial infection of the amniochorion membranes: temporal regulation of microbial interaction and inflammatory/oxidative response, BP.TT

(Only some records are available in English at this moment)

• Abstract

  Normal vaginal flora is commonly defined as the prevalence of Lactobacillus spp. over the many other bacteria that may colonize this milieu. Recent studies have been providing increasing evidence of the strict relation between the bacterial composition of vaginal flora and host's immune response. Moreover, alterations in the levels of inflammatory mediators caused by abnormal vaginal flor…

  Deep proteomic analysis of cervicovaginal fluid in bacterial vaginosis: association with bacterial composition and response to metronidazole treatment, BE.EP.PD