CV Lattes
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ORCID
Ministério da Ciência, Tecnologia e Inovações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Undergraduation in Biological Science at Universidade Estadual de Campinas, PhD in Molecular and Functional Biology - Biochemistry at Universidade Estadual de Campinas, and post-doctoral in Developmental Biology and Genome Editing at CNPEM. (Source: Lattes Curriculum)
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The activity of enzymes in the protein ubiquitination pathway is critical for synaptic development and function, as well as for mitochondrial and cellular homeostasis, and dysregulation of these enzymes has been increasingly associated with neurodevelopmental and neurodegenerative diseases. Intellectual Disability (ID) is characterized by cognitive limitations and deficits in adaptive beh…
Ubiquitination is a post-translational modification involved in many cellular processes, like mitophagy, DNA-damage repair, protein degradation by the ubiquitin-proteasome system, and synaptic transmission. UBE2A, an ubiquitin-conjugating enzyme (E2), may perform these described functions by interacting with other proteins, such as E3 ligases RAD18 and Parkin. Due to cellular functions de…
The CRISPR/Cas9 technology has recently emerged as an effective alternative for the introduction of site-specific modifications into the genome. Compared to the previously techniques, CRISPR/Cas9 has lower cost, greater efficiency and speed to edit the genome in multiple cell types and organisms. The CRISPR/Cas9 system is based on the use of a small RNA which is able to pair with target D…
Ki-1/57 is a regulatory protein, intrinsically unstructured, located in the nucleus and cytoplasm. It is encoded by the gene Habp4, located on chromosome 13 in mice. Several post-translational modifications regulate the function of Ki-1/57 such as phosphorylation by PKC, methylation by PRMT1 and SUMOylation. Yeast Two-hybrid assays and immunoprecipitation from mammalian cells extracts sho…
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 4 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 7 / 6 | All research grants and scholarships |
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