Marcelo Larami Santoro

• Abstract

  Bothrops jararaca snake venom (BjV) remarkably alters Hemostasis and Inflammation, but few studies have examined the interaction between these processes during envenomation, whose understanding is essential to improve the treatment of patients. Various toxins from BjV showing either pro- or anti-hemostatic activities induce bleeding in bitten patients, associated with the presence of thro…

  Hemostasis-inflammation interaction during envenomation by Bothrops jararaca snakes: pathogenesis of thrombocytopenia, and therapeutic anti-ophidian mechanisms of quercetin-3-rutinoside (rutin), AP.R
• 64th Annual Scientific and Standardization Committee (SSC) Meeting of the ISTH, AR.EXT

• Abstract

  The venom of the pit viper Bothrops jararaca (a species that inhabits from southern Bahia state in Brazil to Misiones province in Argentina) interferes in various biological systems in a complex and dynamic manner, leading to the rapid death of their natural preys. Among these biological systems, the hemostatic system is a pivotal target for snake venoms, and particularly B. jararaca veno…

  Isolation and characterization of Brothrops jararaca snake venom proteins that induce thrombocytopenia, AP.R SPRINT

(Only some records are available in English at this moment)

• Abstract

  Bites by Bothrops snakes, which induce disturbances that lead to mortality or morbidity of patients, are a major public health issue in Brazil. Envenomation by Bothrops jararaca snakes induces hemostatic alterations, such as thrombocytopenia, consumptive coagulopathy, and bleedings. Furthermore, it also produces a state of local and systemic inflammatory reaction, leading to activation of…

  Novel mechanisms of pathogenesis of Sepsis and Bothrops envenomation: potential of rutin as a therapeutic agent, BP.DR

• Abstract

  The activity of Bothrops jararaca venom is broad and complex on biologic systems of preys, showing pro- and anti-hemostatic features. Venom proteins may alter by various approaches the hemostatic systems. Several systemic manifestations are described during B. jararaca envenomation, and bleedings are the most conspicuous one. Systemic bleeding is multifactorial, and patients manifest cons…

  Disturbances of Von Willebrand factor and hepatic synthesis of hemosthatic factors induced by experimental Bothrops jararaca envenomation, BP.DR

• Abstract

  Resumo do artigo que está sendo submetido à publicação no Journal of Thrombosis and Haemostasis, referente aos resultados obtidos pela aluna em sua dissertação de mestrado.The release of plasma tissue factor (TF) in bloodstream has never been demonstrated in snake envenomation, although it may aggravate the bleeding tendency. Aiming to investigate the contribution of venom metalloproteina…

  Pathogenesis of systemic hemostatic disturbances induced by Bothrops jararaca snake venom, BP.MS

(Only some records are available in English at this moment)