She holds a master's degree in Biotechnology from the University of São Paulo (1996), a PhD in Sciences (General Physiology) from the University of São Paulo (2002) and a post-doctorate from the University of Lille I (France) (2008). She is currently a Scientific Researcher VI at the Butantan Institute. She has experience in the area of #8203;#8203;Biochemistry, with an emphasis on plasma protein purification and proteomics. She works mainly on the following topics: Plasma proteins and variability of snake venoms in function and factors such as: ontogeny, sex, geographic distribution, health, hemostasis and antivenoms. She is a full supervisor of master's and doctoral degrees in the Interunit Postgraduate Program in Biotechnology at USP/IPT/BUTANTAN. She has international collaboration with the University of Bordeaux (FAPESP-SPRINT) and a regular grant (FAPESP). CNPQ research productivity scholarship - level 2 (Source: Lattes Curriculum)
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Snake envenomation was reintroduced as a neglected tropical disease by the World Health Organization (WHO) in 2017 and represents a serious public health problem for tropical and subtropical regions of developing countries. Naja kaoutia is a snake considered category 1 of medical importance by the WHO. Its venom has a prominent neurotoxic effect due to the two main protein families presen…
The aim of this proposal is to develop a new France-Brazil collaboration to tackle the urgent need to strengthen the implementation of the 3Rs principle (Reduce, Refine and Replace) within the Instituto Butantan, São Paulo, the largest immunobiologicals and biopharmaceuticals producer in Latin America and one of the largest in the world (e.g. world-renowned for its developments of antiven…
According to the World Health Organization, snake envenoming is classified as a neglected disease that mainly affects vulnerable populations in tropical and subtropical countries. Although the main functions of snake venoms are to immobilize, paralyze and kill the prey in order to be able to ingest it safely, due to the complex composition of the venoms, there are several associated patho…
There is a great diversity of venomous and non-venomous snakes in Brazil and in the world. The biological and behavioral differences of these two groups have been increasingly studied. Venomous snakes are responsible for 5 million human accidents per year, a fact that encourages knowledge about all aspects of envenomation. Nowadays, it is known that 90% of the venom of these snakes is com…
Snakes of the genus Crotalus (Viperidae family) are very important from the epidemiological point of view, once, although they account only for about 9% of ophidian accidents, they are with the highest lethality (1.1%). In Brazil, the genus Crotalus is represented by a single species, Crotalus durissus (C.d.), which has a wide geographical distribution in Brazil and has 5 subspecies, C.d.…
(Only some records are available in English at this moment)
Snake envenomation was reintroduced as a neglected tropical disease by the World Health Organization (WHO) in 2017 and represents a serious public health problem for tropical and subtropical regions of developing countries. Naja kaouthia (N. kaouthia) snake is considered category 1 of medical importance by the WHO. Its venom has a prominent neurotoxic effect due to the two main protein fa…
Accidents by venomous snakes results in more than 20,000 reported cases per year in the country (Ministério da Saúde, 2021), and although snakes of the genus Crotalus are not the most responsible for snakebites in Brazil, they have a venom with a low protein complexity, causing a high mortality rate, close to 0.8% (Ministério da Saúde, 2021). The toxins in rattlesnake venom cause a great …
Snake bite envenomination is considered a tropical disease neglected according to the World Health Organization (WHO). In Brazil, snakebites accidents is caused mainly by the genus Bothrops, Crotalus and Lachesis. Lachesis spp. represents one of the largest venomous snakes in the world. In Brazil, there is only the species L. muta, with the subspecies L. muta muta being a snake from the a…
(Only some records are available in English at this moment)
According to Epidemiological Bulletin number 11 published in 2019, between 2007 and 2017, there was a 38.25% growth in occupational accident records involving venomous animals in Brazilian territory, most of them caused by snakes, with Brazil being one of the countries with the highest mortality in this type of accident. The genus Crotalus is one of the main responsible for snakebites in …
Snakes of the genus Crotalus have great medical importance for Brazil due to the number of snakebites caused by these animals. It is the second genus responsible for snakebites and the frequency of recorded deaths. In Latin America we can find Crotalus durissus, a species whose distribution is wide and well determined, inhabiting mainly arid, semi-arid areas and open fields. The subspecie…
Naja kaouthia is a medically important snake from the Elapidae family, widely distributed throughout Southeast Asia in various habitats. This species has a diverse venom composition, including 16 protein families, from which 13 are toxin families, and considerable intraspecific variation. The clinical manifestations of Naja kaouthia snakebite are characterized by predominantly neurotoxic …
(Only some records are available in English at this moment)
The study of variation and quality control of snake venoms has been the subject of intense investigation, given their use in the production of antivenoms and in the search for new products of biotechnological interest. To this end, various biological activities of venoms are studied using both in vivo and in vitro methods. However, it is recognized that have some problems related of curr…
Snake venoms are one of the most complex of known venoms and are one of the most studied animal toxins from the last century to the present day. The venoms represent a critical innovation in the evolution of snakes that allowed the transition of prey capture from a mechanical to chemical, and this innovation played an important role in the diversification and evolution of these animals. C…
Antithrombin is a plasma glycoprotein belonging to the serpin family that plays a key role in controlling hemostasis, acting as an important inhibitor of blood coagulation by inactivating thrombin and other serine proteases, such as factors VIIa, IXa, Xa, XIa and XIIa. In addition to participating as a major physiological inhibitor of blood coagulation, antithrombin has anti-inflammatory …
| 2 / 2 | Ongoing grants |
| 12 / 9 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 16 / 14 | Completed scholarships in Brazil |
| 4 / 3 | Completed scholarships abroad |
| 39 / 33 | All research grants and scholarships |
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CV Lattes
ORCID