Ramon Kaneno

• Abstract

  Interferon alpha (IFN-alpha) is a type I IFN with great therapeutic potential, since it is able to directly fight tumor cells and enhance the maturation of dendritic cells (DCs), the main antigen-presenting cells, required for an effective antitumor response. However, the systemic administration of cytokines can induce severe collateral effects. Therefore, the induction of cytokine secret…

  Interferon-alfa genetherapy for colorectal cancer control, AP.R

• Abstract

  The immunologic tolerance to tumors antigens in cancer patients is one of the main challenges in immunotherapy. Aiming to overcome this tolerance, clinical protocols with dendritic cells (DCs) have been developed, since they are able to induce tumor specific T lymphocyte response. Several approaches have been proposed to improve DCs antigen presentation capacity, including the use of exos…

  Antitumor therapeutic potential of dendritic cells sensitized with allogeneic exosomes loaded with prostatic peptides, AP.R

• Abstract

  We have previously observed that ultra-low concentrations of several antineoplastic agents are able to up-regulate the activity of dendritic cells (DC), as well as modify the transcription of a variety of genes of tumor cells, which seems to induce increased immunogenicity on these cells. Among the genes, which transcription was modified by paclitaxel, we cite those associated with the an…

  Chemoimmunomodulation with antineoplastic agents and generation of dendritic cell vaccine, AP.R

(Only some records are available in English at this moment)

• Abstract

  Cancer is featured by an uncontrolled cell proliferation that change the tissue homeostasis and can trigger complications such as pathways blockade, organ compression, and spreading of transformed cells through metastasis. Colorectal cancer is the third main type of cancer worldwide and the most common treatment strategy is chemotherapy, being 5-fluorouracil (5-FU) one of the main drugs u…

  Effect of autophagy blockade on the immunogenicity of SW620 colorectal cancer cells, BP.IC

• Abstract

  Prostate cancer figures as the main type of tumor in male patients and its treatment is done especially by hormonal blockade and prostatectomy, associated or not with chemo and radiotherapy. In cases in which chemotherapy is used, selected drugs for most cases are taxols, which works by interfering with the microtubule function, leading to cell death. Chemotherapy against prostate cancer …

  Development of gold nanocarriers for antineoplastic drugs, BP.IC

• Abstract

  Colorectal cancer (CRC) is the third most prevalent type of cancer worldwide and frequently associated with metastatic complications. Therapeutic strategies used to treat those patients who do not respond to conventional chemotherapy is based on the application of monoclonal antibodies cetuximab or panitumumab, both directed to the epidermal growth factor receptor (EGFR). However, in some…

  TRANSPORT OF 5-FLUOROURACIL BY FUNCIONALIZED GOLD NANOPARTICLES WITH ANTIBODIES AGAINST EPIDERMAL GROWTH FACTOR RECEPTORS (EGFR AND HER2), BP.MS

(Only some records are available in English at this moment)

• Abstract

  We have observed that treatment of DC with low concentration of some anti-neoplasic agents, is able to upregulate DC functions and phenotype, as well as increase the susceptibility of tumor cells to specific cytotoxic T lymphocytes. Based on this, we analyzed whether the in vivo combination of low-dose chemotherapy and DC vaccine would be able to increase the immune response to the murine…

  Chemoimmunomodulation induced by combination of low concentration of 5-fluorouracil with DC vaccine against murine colorectal cancer, BE.EP.DR