CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduate at Medicina from Universidade de São Paulo (1974), master's at Physiology from Universidade de São Paulo (1973) and ph.d. at Fisiologia from Universidade de São Paulo (1976). Has experience in Physiology, focusing on Cardiovascular Physiology, acting on the following subjects: hypertension, baroreceptor resetting, heart rate, angiotensin ii and angiotensin a ii. (Source: Lattes Curriculum)
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The Autonomic Nervous System (ANS) - Sympathetic and Parasympathetic - plays a role in the physiopathogenesis of cardiovascular diseases. Overall, there is a Sympathetic Overactivity contrasting with the Attenuation of Parasympathetic Function. It has also been demonstrated an interaction between the ANS and the Immune Systems (Innate and Adaptive), despite the mechanisms involved require…
The present study was grouped into five Projects investigating the cardiovascular regulation under physiological - Project 1 - and physiopathological - heart failure (HF) - condition, i.e. Project 2, 3, 4A e 4B.Project 1 aims to characterize the presence of substance P in the axons of the aortic depressor nerve (ADN) and nodose ganglion. To accomplish this, it will be used immunohistochem…
It is well documented an autonomic imbalance in the experimental models of hypertension and also in hypertensive patients, characterized by an increase in sympathetic activity and decrease in vagal activity. More recently, it has been observed that inflammatory aspects have been documented in arterial hypertension leading to the derangement of target organs such as the heart and blood ves…
Sepsis produces pathophysiological changes, with marked hypotension, cardiac depression and decreased systemic perfusion, which contributes to multiple organ dysfunction. Although the cause of death in septic shock is probably multifactorial, myocardial dysfunction is a common complication, occurring prior to the shock. Even if studies in humans suggest the absence of ischemic myocardial …
(Only some records are available in English at this moment)
Rationale. The increase in the prevalence of cardiovascular diseases has motivated the scientific community to seek new approaches for assessing cardiocirculatory performance, mainly associated with Autonomic Regulation (Sympathetic and Parasympathetic). Among these approaches, we highlight the study of the variability of cardiovascular parameters, especially Arterial Pressure and Heart R…
It is well known that arterial hypertension and the inflammatory process are physiologically related (Rothman et al. 2020). Lately, significant progress has been achieved concerning the understanding of the role of the immune system (innate and adaptive) in the pathophysiology of cardiovascular diseases (Dixon et al., 2020). Taking into account that the experimental model of Periodontitis…
Prado et al. (2006) developed a strain of genetically modified mice, which show attenuation of the vesicular acetylcholine transporter (VAChT) (Prado et al., 2006). This strain was named VAChT knockdown (VAChT KD). It is known that even a modest deficiency of VAChT is enough to interfere with neurotransmitter release, thus attenuating Parasympathetic Function. On the other hand, Zhao et a…
The presence of oral inflammation has recently been related to the pathophysiology of cardiovascular diseases. Stomatitis is highly prevalent in patients with dental prosthesis, and its main etiological factor is infection by Candida albicans. Knowing that the interaction between the Innate and Adaptive Immune Systems, and the Neural System, is mediated by the Autonomic Nervous System, th…
Besides presenting baroreflex dysfunction, hypertensive patients also exhibit an increased inflammatory profile, suggesting a possible correlation between the baroreflex function integrity and the immune system. Although studies of our laboratory have shown the anti-inflammatory effects of baroreflex, no previous study explored the physiological reflex activation of the baroreflex, instea…
(Only some records are available in English at this moment)
The impact of depressive behavior on individuals with bipolar disorder is devastating, markedly increasing the risk of suicide and severely compromising their quality of life. It is well established that depressive disorders are strongly linked to both chronic inflammatory conditions and autonomic disfunction. Elevated inflammation levels have been observed to heighten the susceptibility …
Recent advances have strengthened the concept that hypertension has an immunological basis. Studies conducted in Professor Tomasz Guzik's laboratory indicates that T cells are activated in hypertension, and their loss prevents the development of hypertension. Periodontitis is an example of a chronic inflammatory disease that activates innate and adaptive immunity and increases systemicall…
The interaction between the neural and the immune system is vital for the modulation of the innate immune response. Recent advances have considered the role of inflammation in the development of hypertension. Hypertensive patients exhibit increased sympathetic outflow that might contribute to the genesis and maintenance of the high blood pressure levels. Data suggest that the carotid body…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 13 / 10 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 25 / 18 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 48 / 38 | All research grants and scholarships |
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