CV Lattes
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Universidade de Sorocaba (UNISO). Pró-Reitoria de Pós-Graduação, Pesquisa, Extensão e Inovação (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Farmácia from Universidade de São Paulo (1982), master's at Pharmacology from Universidade Estadual de Campinas (1997) and ph.d. at Pharmacology from Universidade Estadual de Campinas (2001). Has experience in Pharmacology, acting on the following subjects: bothrops jararacussu, junção neuromuscular, plantas medicinais, myotoxicity and crotoxin. (Source: Lattes Curriculum)
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Purpose: A silver nanoparticle obtained by reducing salts with solid dispersion of curcumin (130 nm, 0.081 mg/mL-1) was used to counteract against the toxic - edematogenic, myotoxic, and neurotoxic - effects of Philodryas olfersii venom. Methods: The edematogenic effect was evaluated by plasma extravasation in rat dorsal skin after injection of 50 µg per site of venom alone or pre-incubat…
A serious complication to poisoning caused by venomous snakes (Bothrops and Crotalus) is the Acute Kidney Injury (AKI). The prevention of AKI should be attempted in all patients envenomed by venomous animal by early administration of specific antivenom treatment of hypotension, shock and maintaining an adequate state of hydration. On the other hand, phytochemicals as tanin/tannic acid sho…
In this work, we confirmed the ability of the triterpenoid betulin to protect against neurotoxicity caused by Bothrops jararacussu snake venom in vitro in mouse isolated phrenic nerve-diaphragm (PND) preparations and examined its ability to protect in vivo using the rat external popliteal/sciatic nerve-tibialis anterior (EPSTA) preparation. Venom caused complete, irreversible blockade in …
(Only some records are available in English at this moment)
Nanoparticles have been studied in various research areas such as odontology, medicine, electronics, science, computer science, and materials engineering. In the health sphere it is applied in biomedical devices, nanomedicines for neurodegenerative diseases, antibacterial nanoparticles in dentistry, and in the public sanitation sector for water decontamination, among others. In the invest…
The World Health Organization (WHO) estimates that 5.4 million people are annually affected in accidents with venomous snakes, and approximately one tenth of cases come to death or remain permanently deformed, which make these accidents a global public health problem. The search for alternatives that minimize the seriousness of the snake accident is growing, especially in natural sources …
Introduction. The use of gold in medicine mainly in cancer diagnosis and therapies has led to other biological applications, in the form of gold nanoparticles (AuNPs), to act as a drug delivery agent, in contrast in computed tomography, produce bioimages and aid in gene therapy, thanks to its size and properties. Metallic nanoparticles have been investigated against the toxic effects of …
(Only some records are available in English at this moment)
Previously our study with barks hydroalcoholic extract from Dipteryx alata Vogel showed an antiophidian property against the neuromuscular blockade induced by Bothrops jararacussu snake venom. Our objectives are: 1) To obtain extracts of different polarities (hexane, dichloromethane, ethyl acetate and methanol) from barks of D. alata; 2) To identify the extract responsible by antineurotox…